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View Structure Prediction Details

Protein: hcf-1
Organism: Caenorhabditis elegans
Length: 782 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for hcf-1.

Description E-value Query
Range
Subject
Range
gi|73977775 - gi|73977775|ref|XP_867075.1| PREDICTED: similar to host cell factor C2 (predicted) isoform 5 [Canis ...
375.0 [0..25] [748..4]

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Predicted Domain #1
Region A:
Residues: [1-378]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDEDVGLEAT NYSRGDESRS EEQEKNVVRW RIVQQSTGPN PKPRHGHRAV VLKELIVIFG  60
   61 GGNEGMIDEL HAYNTQKREW TAPQCCGDVP TPAAAFGAIS LGNKIYRFGG MTEYGKYTND 120
  121 LYELQSTRWE WRRLNPRVHS NGHLPCPRIG HSFVVSQKSQ KAYVFGGLSN DLNDPKRNVP 180
  181 HYLDDLYVIN LSGPQHLIWE KLNATGPGPI SRESHTAVIY EKDSISRMVV YGGMNGVRLG 240
  241 DLWYLNLNTL HWTEIKFDDP RTGIPPMPRS LHSSVLIGDK MFVYGGWVPL LEHASTEQQT 300
  301 EKEWKCTSSL GCWNITEDRW VPLHLYCSDE DTIPRGRAGH CAAAVGDRMY IWSGRDGYRK 360
  361 AWSNQVCCRD MWLLDTIL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.522879
Match: 1zgkA
Description: 1.35 angstrom structure of the Kelch domain of Keap1
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [379-638]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PEQPGKVQLG RAGFNSLEIS WPIVQGASGY FLQIGFGDAK EQSVSPIKRA TTSPRKQPSI  60
   61 VPPSQKETEQ SPKKPQGTAP SIISTQGTTY TAPADPKPAT DEGGLPQDLF EDTEKNETAS 120
  121 PKRSNDAQSA DSSTCEQKKT DESGLEEDSE KDQKPSDAGE TDEMKEENGD DDLPWFDVGI 180
  181 IDKATINVTH YFNDRQQSLE KQLNDLIDHN AFKCVNDSVF TTEDKIPLIN GQSYRFRVSA 240
  241 INGLGKGAWS ETASCKTCVP 

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.33
Match: 2ibgA
Description: No description for 2ibgA was found.

Predicted Domain #3
Region A:
Residues: [639-782]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GYPSAPSSIR ITKSHEGAQL TWEPPSNTNI SGKIIEYSVY LAVKNQSANS ADSQLAFMRV  60
   61 YCGPQADCQV LQSNLGTAFV DQTNKPAIIF RIAARNEKGY GPATQVRWLQ DQQKIPVRTN 120
  121 YPNNSGFIYQ QHGGQQKRAR FDHQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.0
Match: 1wftA
Description: Solution structure of C-terminal fibronectin type III domain of mouse 1700129L13Rik protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor activity 2.70893613307252 bayes_pls_golite062009
binding 2.6879427326284 bayes_pls_golite062009
transmembrane receptor activity 2.63145351876028 bayes_pls_golite062009
protein binding 2.21770026586875 bayes_pls_golite062009
cytokine binding 1.90627686584923 bayes_pls_golite062009
signal transducer activity 1.54896140065204 bayes_pls_golite062009
molecular transducer activity 1.54896140065204 bayes_pls_golite062009
cytokine receptor activity 1.32127809692757 bayes_pls_golite062009
growth factor binding 1.07003653734093 bayes_pls_golite062009
receptor binding 0.44321055668528 bayes_pls_golite062009
protein dimerization activity 0.0111639672367196 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle