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Protein Overview: daf-3

General Information:
Name(s) found: daf-3 / CE26364 [WormBase]
Description(s) found:
Found 22 descriptions.
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  • WBGene00000899 locus:daf-3 status:Partially_confirmed UniProt:O17532 protein_id:CCD69988.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 796 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEALink to PubMed article]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [IGILink to PubMed article]
    regulation of transcription, DNA-dependent [IEALink to PubMed article]
    Molecular Function: sequence-specific DNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLIATSLLV PDEHTPMMSP VNTTTKILQR SGIKMEIPPY LDPDSQDDDP EDGVNYPDPD  60
   61 LFDTKNTNMT EYDLDVLKLG KPAVDEARKK IEVPDASAPP NKIVEYLMYY RTLKESELIQ 120
  121 LNAYRTKRNR LSLNLVKNNI DREFDQKACE SLVKKLKDKK NDLQNLIDVV LSKGTKYTGC 180
  181 ITIPRTLDGR LQVHGRKGFP HVVYGKLWRF NEMTKNETRH VDHCKHAFEM KSDMVCVNPY 240
  241 HYEIVIGTMI VGQRDHDNRD MPPPHQRYHT PGRQDPVDDM SRFIPPASIR PPPMNMHTRP 300
  301 QPMPQQLPSV GATFAHPLPH QAPHNPGVSH PYSIAPQTHY PLNMNPIPQM PQMPQMPPPL 360
  361 HQGYGMNGPS CSSENNNPFH QNHHYNDISH PNHYSYDCGP NLYGFPTPYP DFHHPFNQQP 420
  421 HQPPQLSQNH TSQQGSHQPG HQGQVPNDPP ISRPVLQPST VTLDVFRRYC RQTFGNRFFE 480
  481 GESEQSGAII RSSNKFIEEF DSPICGVTVV RPRMTDGEVL ENIMPEDAPY HDICKFILRL 540
  541 TSESVTFSGE GPEVSDLNEK WGTIVYYEKN LQIGEKKCSR GNFHVDGGFI CSENRYSLGL 600
  601 EPNPIREPVA FKVRKAIVDG IRFSYKKDGS VWLQNRMKYP VFVTSGYLDE QSGGLKKDKV 660
  661 HKVYGCASIK TFGFNVSKQI IRDALLSKQM ATMYLQGKLT PMNYIYEKKT QEELRREATR 720
  721 TTDSLAKYCC VRVSFCKGFG EAYPERPSIH DCPVWIELKI NIAYDFMDSI CQYITNCFEP 780
  781 LGMEDFAKLG INVSDD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..118] deduced N/A No confident structure predictions are available.
    2 View Details [119..248] PSI-BLAST 47.0 SMAD MH1 domain
    3 View Details [249..357] deduced N/A No confident structure predictions are available.
    4 View Details [358..525] PSI-BLAST 5.69897 Sec24
    5 View Details [526..796] PSI-BLAST 79.69897 Smad4 tumor suppressor C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • binding
    		•  2.31656652567204 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.93348471274042 bayes_pls_golite062009
  • protein binding
    		•  1.67660511831067 bayes_pls_golite062009
  • DNA binding
    		•  1.64107635602436 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.59899290578262 bayes_pls_golite062009
  • transforming growth factor beta receptor, cytoplasmic mediator activity
    		•  0.7615469625125 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.59091508757448 bayes_pls_golite062009
  • transcription factor activity
    		•  0.554078523633227 bayes_pls_golite062009
  • signal transducer activity
    		•  0.29313054064574 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.29313054064574 bayes_pls_golite062009
  • catalytic activity
    		•  0.257477082550163 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase signaling protein activity
    		•  0.17825540288715 bayes_pls_golite062009
  • transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
    		•  0.0594594490862095 bayes_pls_golite062009
  • SMAD binding
    		•  0.0575833066764297 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.0382922567397515 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.0268350196675502 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle