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Protein Overview: nhr-85

General Information:
Name(s) found: nhr-85 / CE26023 [WormBase]
Description(s) found:
Found 24 descriptions.
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  • WBGene00003675 locus:nhr-85 Nuclear hormone receptor family member nhr-85 status:Confirmed UniProt:Q9XUK7 protein_id:CAB04919.2 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 514 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    Biological Process: dauer larval development [IMPLink to PubMed article]
    regulation of transcription, DNA-dependent [IEALink to PubMed article]
    Molecular Function: DNA binding [IEALink to PubMed article]
    transcription factor activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    steroid hormone receptor activity [IEALink to PubMed article]
    sequence-specific DNA binding [IEALink to PubMed article]
    steroid binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDLSTSGSLP CHLPLSLLTN LQTPPIDTSF SSPPATSSSS LLSPSPSSAF RPVVPKSLMN  60
   61 PQPAMDTFYM SAIQSLVVST TNDDQYSEHG ALEGSKSLAK DENASTSAGT ILCQVCSDKA 120
  121 SGFHYGVFAC EGCKGFFRRS IQQKITYRAC TRAEDCLILR NNRNRCQCCR LKKCLAVGMS 180
  181 RDAVRFGRVP KREKARMFEE MQKTNVQSQR DQIAIQYENL TEVMHKINQA FGTLQATLEK 240
  241 CTGPIYTDRC PITSNFIVIP LKAAIDFANS IPAFLSITQT QRVHLLQNSV FDVMLLASAS 300
  301 ASTSQHFPPG GLTYDQSSAN PIIPQAIQSI SARIRQLPPQ TVPILTAIAV CQADLLPESQ 360
  361 QPMLLAERLW CVLGKLGGIQ SLATAPSLLA DVRTLRQWHS DRLRQMSQIS QHFSQNLLIA 420
  421 PVAAAAPVLL PPAFLSPPAS ATSTSSSSVK SEFIERHPSI ASLLERPRRI SSSGAQEPLN 480
  481 LSLPHVRHQV KRDVDSDEQL EEMKVSPVPT TLSE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..103] FFAS03 1.04 Crystal Structure of Rat Synapsin I C Domain Complexed to Ca.ATP
    2 View Details [104..202] PSI-BLAST 26.69897 Orphan nuclear receptor reverb
    3 View Details [203..514] PSI-BLAST 39.69897 Crystal Structure of the RARbeta/RXRalpha Ligand Binding Domain Heterodimer in Complex with 9-cis Retinoic Acid and a Fragment of the TRAP220 Coactivator

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  1.18770607371139 bayes_pls_golite062009
  • protein binding
    		•  0.699012253331291 bayes_pls_golite062009
    3
    Term Confidence Notes
  • binding
    		•  2.07679393058916 bayes_pls_golite062009
  • protein binding
    		•  1.4692467191721 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.38569381220638 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  1.33970394025402 bayes_pls_golite062009
  • receptor activity
    		•  1.27827487658808 bayes_pls_golite062009
  • DNA binding
    		•  1.07558579137079 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.843756208408716 bayes_pls_golite062009
  • signal transducer activity
    		•  0.729591594314124 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.729591594314124 bayes_pls_golite062009
  • transcription factor activity
    		•  0.523911554416 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.14253203697325 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0654022419611198 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.35

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle