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View Structure Prediction Details

Protein: nhr-85
Organism: Caenorhabditis elegans
Length: 514 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for nhr-85.

Description E-value Query
Range
Subject
Range
gi|68396885 - gi|68396885|ref|XP_683221.1| PREDICTED: similar to retinoid X receptor-alpha [Danio rerio]
302.0 [0..4] [426..108]

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Predicted Domain #1
Region A:
Residues: [1-103]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDLSTSGSLP CHLPLSLLTN LQTPPIDTSF SSPPATSSSS LLSPSPSSAF RPVVPKSLMN  60
   61 PQPAMDTFYM SAIQSLVVST TNDDQYSEHG ALEGSKSLAK DEN

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.04
Match: 1pk8A
Description: Crystal Structure of Rat Synapsin I C Domain Complexed to Ca.ATP
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [104-202]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASTSAGTILC QVCSDKASGF HYGVFACEGC KGFFRRSIQQ KITYRACTRA EDCLILRNNR  60
   61 NRCQCCRLKK CLAVGMSRDA VRFGRVPKRE KARMFEEMQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.69897
Match: 1a6yA
Description: Orphan nuclear receptor reverb
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.18770607371139 bayes_pls_golite062009
protein binding 0.699012253331291 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [203-514]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KTNVQSQRDQ IAIQYENLTE VMHKINQAFG TLQATLEKCT GPIYTDRCPI TSNFIVIPLK  60
   61 AAIDFANSIP AFLSITQTQR VHLLQNSVFD VMLLASASAS TSQHFPPGGL TYDQSSANPI 120
  121 IPQAIQSISA RIRQLPPQTV PILTAIAVCQ ADLLPESQQP MLLAERLWCV LGKLGGIQSL 180
  181 ATAPSLLADV RTLRQWHSDR LRQMSQISQH FSQNLLIAPV AAAAPVLLPP AFLSPPASAT 240
  241 STSSSSVKSE FIERHPSIAS LLERPRRISS SGAQEPLNLS LPHVRHQVKR DVDSDEQLEE 300
  301 MKVSPVPTTL SE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 39.69897
Match: 1xdkB
Description: Crystal Structure of the RARbeta/RXRalpha Ligand Binding Domain Heterodimer in Complex with 9-cis Retinoic Acid and a Fragment of the TRAP220 Coactivator
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.07679393058916 bayes_pls_golite062009
protein binding 1.4692467191721 bayes_pls_golite062009
transcription regulator activity 1.38569381220638 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 1.33970394025402 bayes_pls_golite062009
receptor activity 1.27827487658808 bayes_pls_golite062009
DNA binding 1.07558579137079 bayes_pls_golite062009
nucleic acid binding 0.843756208408716 bayes_pls_golite062009
signal transducer activity 0.729591594314124 bayes_pls_golite062009
molecular transducer activity 0.729591594314124 bayes_pls_golite062009
transcription factor activity 0.523911554416 bayes_pls_golite062009
sequence-specific DNA binding 0.14253203697325 bayes_pls_golite062009
transcription activator activity 0.0654022419611198 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle