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Protein Overview: ced-9

General Information:
Name(s) found: ced-9 / CE25104 [WormBase]
Description(s) found:
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  • WBGene00000423 locus:ced-9 Apoptosis regulator ced-9 status:Confirmed UniProt:P41958 protein_id:CAA82573.2 [WormBase]
  • gi|6434316|emb|CAA82573.2| C. elegans protein T07C4.8, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • pir||A53189 apoptosis suppressor CED-9 - Caenorhabditis elegans [NCBI NR]
  • gi|433176|gb|AAA20080.1| CED-9 [Caenorhabditis elegans] [NCBI NR]
  • gi|17552728|ref|NP_499284.1| CEll Death abnormality family member (ced-9) [Caenorhabditis elegans] [NCBI NR]
  • gi|1168881|sp|P41958.1|CED9_CAEEL RecName: Full=Apoptosis regulator ced-9; AltName: Full=Cell death protein 9 [NCBI NR]
  • Apoptosis regulator ced-9 OS=Caenorhabditis elegans GN=ced-9 PE=1 SV=1 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE25104 WBGene00000423 locus:ced-9 Apoptosis regulator proteins, Bcl-2 family status:Partially_confirmed SW:P41958 protein_id:CAA82573.2 [wormpep150.fasta]
  • 25104 WBGene00000423 locus:ced-9 Apoptosis regulator proteins, Bcl-2 family status:Partially_confirmed SW:P41958 protein_id:CAA82573.2 [wormpep130-phg-ecoli-orf-rand.fasta]
  • mev-1 : succinate dehydrogenase cytochrome b, ced-9 : apoptosis regulator of the Bcl2 family, cytochrome, apoptosis regulator BCL2, CEll Death abnormality CED-9, abnormal MEthyl Viologen sensitivity MEV-1 (mev-1ANDced-9) [Caenorhabditis elegans]gi|643431 [nrdb_11152004_Chlamydomonas]
  • locus:ced-9 Apoptosis regulator proteins, Bcl-2 family status:Partially_confirmed SW:P41958 protein_id:CAA82573.2 [wormpep115.fasta.reversed]
  • CE25104 locus:ced-9 Apoptosis regulator proteins, Bcl-2 family status:Partially_confirmed SW:P41958 protein_id:CAA82573.2 [wormpep80.hongbin]
  • CE25104 WBGene00000423 locus:ced-9 Apoptosis regulator proteins, Bcl-2 family status:Confirmed UniProt:P41958 protein_id:CAA82573.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE25104 WBGene00000423 locus:ced-9 Apoptosis regulator proteins, Bcl-2 family status:Confirmed UniProt:P41958 protein_id:CAA82573.2| [wormORF-contam.fasta]
  • Apoptosis regulator ced-9 (Cell death protein 9) [nr-271106-contam.fasta]
  • Hypothetical protein T07C4.8 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CEll Death abnormality family member (ced-9) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CED-9 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE25104 WBGene00000423 locus:ced-9 Apoptosis regulator proteins, Bcl-2 family status:Confirmed SW:P41958 protein_id:CAA82573.2 [WormBase_C-elegans_wp180_08-19-2007_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE25104 WBGene00000423 locus:ced-9 status:Confirmed UniProt:P41958 protein_id:CAA82573.2 Apoptosis regulator ced-9 [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 280 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [IDALink to PubMed article]
    perinuclear region of cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    organelle membrane [IDALink to PubMed article]
    Biological Process: cell death [IMPLink to PubMed article]
    anti-apoptosis [IGILink to PubMed article][IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed article]
    regulation of apoptosis [IEALink to PubMed article]
    negative regulation of programmed cell death [IMPLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTRCTADNSL TNPAYRRRTM ATGEMKEFLG IKGTEPTDFG INSDAQDLPS PSRQASTRRM  60
   61 SIGESIDGKI NDWEEPRLDI EGFVVDYFTH RIRQNGMEWF GAPGLPCGVQ PEHEMMRVMG 120
  121 TIFEKKHAEN FETFCEQLLA VPRISFSLYQ DVVRTVGNAQ TDQCPMSYGR LIGLISFGGF 180
  181 VAAKMMESVE LQGQVRNLFV YTSLFIKTRI RNNWKEHNRS WDDFMTLGKQ MKEDYERAEA 240
  241 EKVGRRKQNR RWSMIGAGVT AGAIGIVGVV VCGRMMFSLK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..280] PSI-BLAST 44.0 Structure of a CED-4/CED-9 complex

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.68532136060219 bayes_pls_golite062009
  • protein binding
    		•  1.27467799975395 bayes_pls_golite062009
  • BH3 domain binding
    		•  0.73278409982916 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.717110763227649 bayes_pls_golite062009
  • BH domain binding
    		•  0.513227895728431 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.0857017957923898 bayes_pls_golite062009
  • caspase inhibitor activity
    		•  0.0810673056766702 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle