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Protein Overview: aco-2

General Information:
Name(s) found: aco-2 / CE25005 [WormBase]
Description(s) found:
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  • WBGene00000041 locus:aco-2 Probable aconitate hydratase, mitochondrial status:Confirmed UniProt:P34455 protein_id:CCD63454.1 [WormBase]
  • gi|25149337|ref|NP_741235.1| ACOnitase family member (aco-2) [Caenorhabditis elegans] [NCBI NR]
  • gi|21264394|sp|P34455.2|ACON_CAEEL RecName: Full=Probable aconitate hydratase, mitochondrial; Short=Aconitase; AltName: Full=Citrate hydro-lyase; Flags: Precursor [NCBI NR]
  • gi|15145362|gb|AAA28050.2| Aconitase protein 2, isoform a [Caenorhabditis elegans] [NCBI NR]
  • Probable aconitate hydratase, mitochondrial OS=Caenorhabditis elegans GN=aco-2 PE=3 SV=2 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE25005 WBGene00000041 locus:aco-2 Aconitate hydratase status:Confirmed SW:P34455 protein_id:AAA28050.2 [wormpep150.fasta]
  • 25005 WBGene00000041 locus:aco-2 Aconitate hydratase status:Confirmed SW:P34455 protein_id:AAA28050.2 [wormpep130-phg-ecoli-orf-rand.fasta]
  • ACOnitase (84.0 kD) (aco-2) [Caenorhabditis elegans]gi|15145362|gb|AAA28050.2| Aconitase protein 2, isoform a [Caenorhabditis elegans]gi|21264394|sp|P34455|ACON_CAEEL Probable aconitate hydratase, mitochondrial precursor (Citrate hydro-lyase) (Aconitase [nrdb_11152004_Chlamydomonas]
  • locus:aco-2 Aconitate hydratase status:Confirmed SW:P34455 protein_id:AAA28050.2 [wormpep115.fasta.reversed]
  • CE25005 Aconitate hydratase status:Confirmed SW:P34455 protein_id:AAA28050.2 [wormpep80.hongbin]
  • CE25005 WBGene00000041 locus:aco-2 Aconitate hydratase status:Confirmed UniProt:P34455 protein_id:AAA28050.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE25005 WBGene00000041 locus:aco-2 Aconitate hydratase status:Confirmed UniProt:P34455 protein_id:AAA28050.2| [wormORF-contam.fasta]
  • Probable aconitate hydratase, mitochondrial precursor (Citrate hydro-lyase) (Aconitase) [nr-271106-contam.fasta]
  • Aconitase protein 2, isoform a [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • ACOnitase family member (aco-2) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE25005 WBGene00000041 locus:aco-2 Aconitate hydratase status:Confirmed UniProt:P34455 protein_id:CCD63454.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE25005 WBGene00000041 locus:aco-2 status:Confirmed UniProt:P34455 protein_id:CCD63454.1 Probable aconitate hydratase, mitochondrial [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 777 amino acids

    Gene Ontology:
    Cellular Component: 3-isopropylmalate dehydratase complex [IEALink to PubMed article]
    Biological Process: lysine biosynthetic process [IEALink to PubMed article]
    locomotory behavior [IMPLink to PubMed articleLink to PubMed article]
    hermaphrodite genitalia development [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    metabolic process [IEALink to PubMed article]
    leucine biosynthetic process [IEALink to PubMed article]
    tricarboxylic acid cycle [IEALink to PubMed article]
    cellular amino acid biosynthetic process [IEALink to PubMed article]
    reproduction [IMPLink to PubMed article]
    growth [IMPLink to PubMed article]
    Molecular Function: hydro-lyase activity [IEALink to PubMed article]
    homoaconitate hydratase activity [IEALink to PubMed article]
    4 iron, 4 sulfur cluster binding [IEALink to PubMed article]
    3-isopropylmalate dehydratase activity [IEALink to PubMed article]
    aconitate hydratase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSLLRLSHL AGPAHYRALH SSSSIWSKVA ISKFEPKSYL PYEKLSQTVK IVKDRLKRPL  60
   61 TLSEKILYGH LDQPKTQDIE RGVSYLRLRP DRVAMQDATA QMAMLQFISS GLPKTAVPST 120
  121 IHCDHLIEAQ KGGAQDLARA KDLNKEVFNF LATAGSKYGV GFWKPGSGII HQIILENYAF 180
  181 PGLLLIGTDS HTPNGGGLGG LCIGVGGADA VDVMADIPWE LKCPKVIGIK LTGKLNGWTS 240
  241 AKDVILKVAD ILTVKGGTGA IVEYFGPGVD SISATGMGTI CNMGAEIGAT TSVFPYNESM 300
  301 YKYLEATGRK EIAEEARKYK DLLTADDGAN YDQIIEINLD TLTPHVNGPF TPDLASSIDK 360
  361 LGENAKKNGW PLDVKVSLIG SCTNSSYEDM TRAASIAKQA LDKGLKAKTI FTITPGSEQV 420
  421 RATIERDGLS KIFADFGGMV LANACGPCIG QWDRQDVKKG EKNTIVTSYN RNFTGRNDAN 480
  481 PATHGFVTSP DITTAMAISG RLDFNPLTDE LTAADGSKFK LQAPTGLDLP PKGYDPGEDT 540
  541 FQAPSGSGQV DVSPSSDRLQ LLSPFDKWDG KDLEDMKILI KVTGKCTTDH ISAAGPWLKY 600
  601 RGHLDNISNN LFLTAINADN GEMNKVKNQV TGEYGAVPAT ARKYKADGVR WVAIGDENYG 660
  661 EGSSREHAAL EPRHLGGRAI IVKSFARIHE TNLKKQGMLP LTFANPADYD KIDPSDNVSI 720
  721 VGLSSFAPGK PLTAIFKKTN GSKVEVTLNH TFNEQQIEWF KAGSALNRMK EVFAKSK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..777] PSI-BLAST 1000.0 STRUCTURE OF ACTIVATED ACONITASE. FORMATION OF THE (4FE-4S) CLUSTER IN THE CRYSTAL

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • 3-isopropylmalate dehydratase activity
    		•  11.6597692115322 bayes_pls_golite062009
  • aconitate hydratase activity
    		•  5.86356477922338 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  2.93956285477489 bayes_pls_golite062009
  • catalytic activity
    		•  2.4040324437254 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.25736437672211 bayes_pls_golite062009
  • carbon-oxygen lyase activity
    		•  2.08349115784849 bayes_pls_golite062009
  • hydro-lyase activity
    		•  2.04845291489052 bayes_pls_golite062009
  • lyase activity
    		•  2.0080619912194 bayes_pls_golite062009
  • metal cluster binding
    		•  1.70706327499066 bayes_pls_golite062009
  • iron-sulfur cluster binding
    		•  1.70706327499066 bayes_pls_golite062009
  • binding
    		•  1.67914740974449 bayes_pls_golite062009
  • DNA binding
    		•  1.6436451615422 bayes_pls_golite062009
  • iron-responsive element binding
    		•  1.1980380564483 bayes_pls_golite062009
  • iron ion binding
    		•  1.12961684198784 bayes_pls_golite062009
  • 4 iron, 4 sulfur cluster binding
    		•  1.11810757572823 bayes_pls_golite062009
  • mRNA binding
    		•  1.0310744464034 bayes_pls_golite062009
  • structural molecule activity
    		•  0.870913754566634 bayes_pls_golite062009
  • RNA binding
    		•  0.42311333660604 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.342428816025605 bayes_pls_golite062009
  • protein binding
    		•  0.232638130896339 bayes_pls_golite062009
  • cation binding
    		•  0.0272064751959212 bayes_pls_golite062009
  • metal ion binding
    		•  0.0272064751959212 bayes_pls_golite062009
  • ion binding
    		•  0.0228992031160024 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.86

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle