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Protein Overview: let-756

General Information:
Name(s) found: let-756 / CE24786 [WormBase]
Description(s) found:
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  • WBGene00002881 locus:let-756 Protein let-756 status:Confirmed UniProt:Q11184 protein_id:CCD63193.1 [WormBase]
  • gi|3549721|emb|CAA09234.1| LET-756 protein [Caenorhabditis elegans] [NCBI NR]
  • gi|21264466|sp|Q11184.2|LE756_CAEEL RecName: Full=Protein let-756; AltName: Full=Lethal protein 756 [NCBI NR]
  • gi|17554196|ref|NP_498403.1| LEThal family member (let-756) [Caenorhabditis elegans] [NCBI NR]
  • gi|15145277|gb|AAB53825.2| Lethal protein 756 [Caenorhabditis elegans] [NCBI NR]
  • Protein let-756 OS=Caenorhabditis elegans GN=let-756 PE=1 SV=2 [Swiss-Prot]
  • (Q11184) Let-756 protein (Lethal protein 756) [Swiss-Prot]
  • [wormpep67.fasta]
  • CE24786 WBGene00002881 locus:let-756 heparin-binding gf status:Confirmed SW:Q11184 protein_id:AAB53825.2 [wormpep150.fasta]
  • 24786 WBGene00002881 locus:let-756 heparin-binding gf status:Confirmed SW:Q11184 protein_id:AAB53825.2 [wormpep130-phg-ecoli-orf-rand.fasta]
  • fibroblast growth factor, human FGF20-like, LEThal LET-756 (49.6 kD) (let-756) [Caenorhabditis elegans]gi|15145277|gb|AAB53825.2| Lethal protein 756 [Caenorhabditis elegans]gi|3549721|emb|CAA09234.1| LET-756 protein [Caenorhabditis elegans]gi|21264466| [nrdb_11152004_Chlamydomonas]
  • locus:let-756 heparin-binding gf status:Confirmed SW:Q11184 protein_id:AAB53825.2 [wormpep115.fasta.reversed]
  • CE24786 locus:let-756 heparin-binding gf status:Confirmed [wormpep80.hongbin]
  • CE24786 WBGene00002881 locus:let-756 heparin-binding gf status:Confirmed UniProt:Q11184 protein_id:AAB53825.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE24786 WBGene00002881 locus:let-756 heparin-binding gf status:Confirmed UniProt:Q11184 protein_id:AAB53825.2| [wormORF-contam.fasta]
  • Lethal protein 756 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • LEThal family member (let-756) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • LET-756 protein [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Protein let-756 (Lethal protein 756) [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE24786 WBGene00002881 locus:let-756 heparin-binding gf status:Confirmed UniProt:Q11184 protein_id:CCD63193.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE24786 WBGene00002881 locus:let-756 status:Confirmed UniProt:Q11184 protein_id:CCD63193.1 Protein let-756 [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 425 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    cytoplasm [IDA]
    nuclear speck [IDA]
    nucleolus [IDA]
    extracellular region [IDA]
    U1 snRNP [IDA]
    Biological Process: regulation of axon extension involved in axon guidance [IMP]
    nematode larval development [IMP]
    positive regulation of growth rate [IMP]
    fibroblast growth factor receptor signaling pathway [IMP]
    negative regulation of cell projection organization [IMP]
    Molecular Function: growth factor activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVPAASSIV SYGGAATSNF LTTPVTPFLA GFYNSNFVTD RINSCAPYRV DRIRKQLQDE  60
   61 EENGYPPADD RRRGALFCRS GTWLEMLPIE NPDDGSTRVK VHGTKEESSK FSIVEFVSVA 120
  121 MSLVSIRGVE TKNFICMDPS GKLYATPSSN YSTECVFLEE MMENYYNLYA SCAYGDRFNP 180
  181 WYIELRRSGK PRRGPNSKKR RKASHFLVVH HDLDRLRSPV PNGNDVTDLV VASLFHQPPS 240
  241 HPLFRQQTVT KPPNPHRISN LRAKVEMTNQ AEKQRLLEEK KRRREKKKRR REDRLRKEEQ 300
  301 IREARRQELK SLREEELRRR YQQQQQQQAS TQTRYNRPQN PANPYPTYRP LPTRSTVQSP 360
  361 RPAYNPYWQS PVTQAPHHNS HHHHHHHPRV SSSSDPQQRH QSQQHYLAQT VSNPNRQNVN 420
  421 YQRYP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..196] PSI-BLAST 46.522879 Fibroblast growth factor 9, FGF9
    2 View Details [197..425] PSI-BLAST 6.154902 Heavy meromyosin subfragment

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • fibroblast growth factor receptor binding
    		•  5.68976822724664 bayes_pls_golite062009
  • growth factor activity
    		•  5.6790632853895 bayes_pls_golite062009
  • receptor binding
    		•  4.8109037277027 bayes_pls_golite062009
  • cytokine activity
    		•  3.72907359340826 bayes_pls_golite062009
  • protein binding
    		•  2.99442649109752 bayes_pls_golite062009
  • binding
    		•  2.90110516688922 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  2.49177421879896 bayes_pls_golite062009
  • heparin binding
    		•  2.1616134585534 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.81686028727894 bayes_pls_golite062009
  • interleukin-1 receptor binding
    		•  0.8084616632765 bayes_pls_golite062009
  • pattern binding
    		•  0.323275442862789 bayes_pls_golite062009
  • nerve growth factor receptor binding
    		•  0.308245352535379 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.56

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle