Protein Overview: par-1

General Information:
Name(s) found:	par-1 / CE23838 [WormBase]
Description(s) found: SHOW ONLY BEST	WBGene00003916 locus:par-1 Serine\/threonine-protein kinase par-1 status:Confirmed UniProt:Q9TW45 protein_id:CAB54263.1 [WormBase] pir\|\|T18611 probable serine/threonine-specific protein kinase (EC 2.7.1.-), long splice form - Caenorhabditis elegans [NCBI NR] gi\|71997531\|ref\|NP_001024018.1\| abnormal embryonic PARtitioning of cytoplasm family member (par-1) [Caenorhabditis elegans] [NCBI NR] gi\|5824528\|emb\|CAB54263.1\| C. elegans protein H39E23.1a, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR] gi\|5824362\|emb\|CAB54179.1\| C. elegans protein H39E23.1a, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR] ref\|NP_506499.1\| serine/threonine kinase, establishes embryonic polarity; asymmetrically distributed., abnormal embryonic PARtitioning of cytoplasm PAR-1, ZYGote defective : embryonic lethal ZYG-14 (126.3 kD) (par-1) [Caenorhabditis elegans] [NCBI NR] Serine/threonine-protein kinase par-1 OS=Caenorhabditis elegans GN=par-1 PE=1 SV=1 [Swiss-Prot] [wormpep67.fasta] CE23838 WBGene00003916 locus:par-1 serine\/threonine kinase (KIN1\/SNF1\/Nim1 subfamily) status:Confirmed TR:Q9TW45 protein_id:CAB54263.1 [wormpep150.fasta] 23838 WBGene00003916 locus:par-1 serine\/threonine kinase (KIN1\/SNF1\/Nim1 subfamily) status:Confirmed TR:Q9TW45 protein_id:CAB54263.1 [wormpep130-phg-ecoli-orf-rand.fasta] serine/threonine kinase, establishes embryonic polarity; asymmetrically distributed., abnormal embryonic PARtitioning of cytoplasm PAR-1, ZYGote defective : embryonic lethal ZYG-14 (126.3 kD) (par-1) [Caenorhabditis elegans]gi\|5824528\|emb\|CAB54263.1\| Hyp [nrdb_11152004_Chlamydomonas] locus:par-1 serine\/threonine kinase (KIN1\/SNF1\/Nim1 subfamily) status:Confirmed TR:Q9TW45 protein_id:CAB54263.1 [wormpep115.fasta.reversed] CE23838 locus:par-1 serine\/threonine kinase (KIN1\/SNF1\/Nim1 subfamily) status:Confirmed TR:Q9TW45 protein_id:CAB54263.1 [wormpep80.hongbin] CE23838 WBGene00003916 locus:par-1 serine\/threonine kinase (KIN1\/SNF1\/Nim1 subfamily) status:Confirmed UniProt:Q9TW45_CAEEL protein_id:CAB54263.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta] CE23838 WBGene00003916 locus:par-1 serine\/threonine kinase (KIN1\/SNF1\/Nim1 subfamily) status:Confirmed UniProt:Q9TW45_CAEEL protein_id:CAB54263.1\| [wormORF-contam.fasta] Hypothetical protein H39E23.1a [Caenorhabditis elegans] [nr-271106-contam.fasta] abnormal embryonic PARtitioning of cytoplasm family member (par-1) [Caenorhabditis elegans] [nr-271106-contam.fasta] CE23838 WBGene00003916 locus:par-1 serine\/threonine kinase (KIN1\/SNF1\/Nim1 subfamily) status:Confirmed UniProt:Q9TW45 protein_id:CAB54263.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta] [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr] CE23838 WBGene00003916 locus:par-1 status:Confirmed UniProt:Q9TW45 protein_id:CAB54263.1 Serine\/threonine-protein kinase par-1 [wormpep246-ecoli-contam.fasta]
Organism:	Caenorhabditis elegans
Length:	1192 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IEA] membrane [IDA]
Biological Process:	polarity specification of anterior/posterior axis [TAS] embryonic cleavage [IMP] vulval development [IMP] hermaphrodite genitalia development [IMP] establishment of mitotic spindle localization [IMP] asymmetric protein localization involved in cell fate determination [IMP] signal transduction [IEA] embryonic pattern specification [IGI][IMP] embryonic development ending in birth or egg hatching [IMP ] establishment of cell polarity [IMP] gamete generation [IMP] protein amino acid phosphorylation [IEA]
Molecular Function:	magnesium ion binding [IEA] ATP binding [IEA] protein tyrosine kinase activity [IEA] zinc ion binding [IEA] non-membrane spanning protein tyrosine kinase activity [IEA] protein kinase activity [IEA] protein serine/threonine kinase activity [IEA][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSASVGKKP EHVNTPPGDN QQKSSKENQK SNKDKQSSNQ PPGQIPHSTN SGTRKSSGSG  60
   61 LKTANLKHPA RPSTESSTSS SHHRRPAQEM NGTSTATATG GGGTSGATTT ASSGAPAASS 120
  121 GGSSARYSSS GRSHPTSGSS SSHARSTGQS GMSSRSAARR NDQDVHVGKY KLLKTIGKGN 180
  181 FAKVKLAKHV ITGHEVAIKI IDKTALNPSS LQKLFREVKI MKQLDHPNIV KLYQVMETEQ 240
  241 TLYLVLEYAS GGEVFDYLVA HGRMKEKEAR AKFRQIVSAV QYLHSKNIIH RDLKAENLLL 300
  301 DQDMNIKIAD FGFSNTFSLG NKLDTFCGSP PYAAPELFSG KKYDGPEVDV WSLGVILYTL 360
  361 VSGSLPFDGQ NLKELRERVL RGKYRIPFYM STDCENLLKK FLVINPQRRS SLDNIMKDRW 420
  421 MNVGYEDDEL KPFIEPPKDQ IDEQRIEKLI QIFQLGFNKA AILESVEKEK FEDIHATYLL 480
  481 LGERKSDMDA SEITMAQSLL SHSSINVSSS LGQHPAGVIT REHVTSSSAS GSSASPSRYS 540
  541 RSSATATGAS ITAGSALASA ANAQKHQQSS AAPSSGSSSS RRSSQNDAAA TAAGGTVVMS 600
  601 GTRHGGVQMR AQPTSRQATI SLLQPPSYKP SSNTTQIAQI PPLFNRNSTA TSSAAQPSTG 660
  661 ITGTRKIADP KGRIPLNSTA VQGHRTATGA VAANNGGIPS HRDHAQQQQY MNQLTSSTMM 720
  721 SKLINKTPAA GGTAATSSSS SSSATSTAPL QKSGSQISHA PTEPVIREDD DENNSENQNG 780
  781 NVPLIGGVGP QTSPAVQVPT EDATSSSDKE QQQQKASSET PKESKPSMIH QSPSMPPSQM 840
  841 MTAMESLKLS ESGQTGGPTV ATGGPPQRAT SQQMSRSATT NSANMGASSG GAAAAASATN 900
  901 QLSGAPSSTG ASSQQYHPKA PSSSSSSSTN PPHQHQLTHN ASFSVTPSSY QIPTSTAVNV 960
  961 TSTGMPTSSS SSAFPRNTRN RQTFHGKTEK DKGGDDSSDE IGETPGNVSI GATGPSANNA1020
 1021 EATIWSKLSK LTRRDHNRES MTQPVSGRAG TIGASQGQQT AAALAAIREQ SGPIAPGAGQ1080
 1081 VAPSLPIHEG DVKPRSLRFT WSMKTTSSLA PDDMMREIRK VLDANGCDYE QRERYMILCV1140
 1141 HGDPNTDSLV QWEMEVCKLP RLSLNGVRFK RISGTSIGFK NIASKIAQEL NL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	None Entered	No Comments	Cheeseman, I.M., et al. (2004)
View Run	gi\|7499968	No Comments	Cheeseman, I.M., et al. (2004)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.91

Protein Overview: par-1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: