Protein Overview: ptp-1

General Information:
Name(s) found:	ptp-1 / CE23603 [WormBase]
Description(s) found: SHOW ONLY BEST	WBGene00004213 locus:ptp-1 Tyrosine-protein phosphatase 1 status:Partially_confirmed UniProt:P28191 protein_id:CAB54194.1 [WormBase] pir\|\|T19630 hypothetical protein C48D5.2b - Caenorhabditis elegans [NCBI NR] gi\|5824394\|emb\|CAB54194.1\| C. elegans protein C48D5.2b, partially confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR] gi\|17554412\|ref\|NP_497733.1\| Protein Tyrosine Phosphatase family member (ptp-1) [Caenorhabditis elegans] [NCBI NR] [wormpep67.fasta] CE23603 WBGene00004213 locus:ptp-1 status:Partially_confirmed TR:Q9U3N7 protein_id:CAB54194.1 [wormpep150.fasta] 23603 WBGene00004213 locus:ptp-1 status:Partially_confirmed TR:Q9U3N7 protein_id:CAB54194.1 [wormpep130-phg-ecoli-orf-rand.fasta] protein tyrosine phosphatase (68.8 kD) (ptp-1) [Caenorhabditis elegans]gi\|5824394\|emb\|CAB54194.1\| Hypothetical protein C48D5.2b [Caenorhabditis elegans]gi\|7497608\|pir\|\|T19630 hypothetical protein C48D5.2b - Caenorhabditis elegans [nrdb_11152004_Chlamydomonas] locus:ptp-1 status:Partially_confirmed TR:Q9U3N7 protein_id:CAB54194.1 [wormpep115.fasta.reversed] CE23603 locus:ptp-1 status:Partially_confirmed TR:Q9U3N7 protein_id:CAB54194.1 [wormpep80.hongbin] CE23603 WBGene00004213 locus:ptp-1 status:Partially_confirmed UniProt:PTP1_CAEEL protein_id:CAB54194.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta] CE23603 WBGene00004213 locus:ptp-1 status:Partially_confirmed UniProt:PTP1_CAEEL protein_id:CAB54194.1\| [wormORF-contam.fasta] Protein Tyrosine Phosphatase family member (ptp-1) [Caenorhabditis elegans] [nr-271106-contam.fasta] Hypothetical protein C48D5.2b [Caenorhabditis elegans] [nr-271106-contam.fasta] CE23603 WBGene00004213 locus:ptp-1 status:Partially_confirmed SW:P28191 protein_id:CAB54194.1 [WormBase_C-elegans_wp180_08-19-2007_reversed.fasta] CE23603 WBGene00004213 locus:ptp-1 status:Partially_confirmed UniProt:P28191 protein_id:CAB54194.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta] [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr] CE23603 WBGene00004213 locus:ptp-1 status:Partially_confirmed UniProt:P28191 protein_id:CAB54194.1 Tyrosine-protein phosphatase 1 [wormpep246-ecoli-contam.fasta] Isoform of P28191, Isoform b of Tyrosine-protein phosphatase 1 OS=Caenorhabditis elegans GN=ptp-1 [CAEEL.fasta.20160308]
Organism:	Caenorhabditis elegans
Length:	624 amino acids
Gene Ontology:
Cellular Component:	cytoskeleton [IEA] cytoplasm [IEA] extrinsic to membrane [IEA]
Biological Process:	protein amino acid dephosphorylation [IEA] dephosphorylation [IEA]
Molecular Function:	protein binding [IEA] protein tyrosine phosphatase activity [IEA] phosphatase activity [IEA] cytoskeletal protein binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEVPAFVGKA CLKLKGLCVN VWTATVATCQ ENAEIDEKLP PRAFRESSAP SLRQQRLSKE  60
   61 AIYYGTQESC DEKSWTPSMA CTSTSPGIHA STASVRPVSS GSTPNGASRK SANSGYSGYG 120
  121 YATQTQQPTS TTNASYSPYL NGTISRSSGA AVAKAAARGL PPTNQQAYNT SSPRNSVASY 180
  181 SSFASAGIGG SPPRSKRSPQ SNKSSSPVGE DQVVTIKMRP DRHGRFGFNV KGGADQNYPV 240
  241 IVSRVAPGSS ADKCQPRLNE GDQVLFIDGR DVSTMSHDHV VQFIRSARSG LNGGELHLTI 300
  301 RPNVYRLGEE VDEPDSTMVP EPARVADSVP NSDKLSKSLQ LLADSLNSGK VVDHFEMLYR 360
  361 KKPGMSMNIC RLTANLAKNR YRDVCPYDDT RVTLQASPSG DYINANYVNM EIPSSGIVNR 420
  421 YIACQGPLAH TSSDFWVMVW EQHCTTIVML TTITERGRVK CHQYWPRVFE TQEYGRLMIK 480
  481 CIKDKQTTNC CYREFSIRDR NSSEERRVTQ MQYIAWPDHG VPDDPKHFIQ FVDEVRKARQ 540
  541 GSVDPIVVHC SAGIGRTGVL ILMETAACLV ESNEPVYPLD IVRTMRDQRA MLIQTPGQYT 600
  601 FVCESILRAY HDGTIKPLAE YSKR

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
protein binding	3.40921081688513	bayes_pls_golite062009
binding	3.2595117613307	bayes_pls_golite062009
phosphatase activity	2.36315753814254	bayes_pls_golite062009
phosphoprotein phosphatase activity	2.3400854724675	bayes_pls_golite062009
phosphoric ester hydrolase activity	2.31425709018481	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	2.0332243159956	bayes_pls_golite062009
kinase activity	1.60310055540266	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.42576125485675	bayes_pls_golite062009
transcription regulator activity	1.37626136403014	bayes_pls_golite062009
transporter activity	1.18978519116375	bayes_pls_golite062009
protein tyrosine phosphatase activity	1.10674192505247	bayes_pls_golite062009
transmembrane transporter activity	1.07211582292329	bayes_pls_golite062009
molecular transducer activity	1.06018756723145	bayes_pls_golite062009
signal transducer activity	1.06018756723145	bayes_pls_golite062009
transferase activity	1.02891276124789	bayes_pls_golite062009
PDZ domain binding	0.87883331498113	bayes_pls_golite062009
receptor binding	0.867295068429704	bayes_pls_golite062009
substrate-specific transporter activity	0.755223974149211	bayes_pls_golite062009
beta-catenin binding	0.740091060781601	bayes_pls_golite062009
protein domain specific binding	0.64214865642772	bayes_pls_golite062009
peptidase activity	0.555029889463539	bayes_pls_golite062009
protein kinase binding	0.54934142458843	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.549085929250683	bayes_pls_golite062009
kinase binding	0.541050170070789	bayes_pls_golite062009
hydrolase activity	0.534910002338727	bayes_pls_golite062009
enzyme binding	0.46071739042312	bayes_pls_golite062009
cell adhesion molecule binding	0.403457741099606	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	0.281958912690177	bayes_pls_golite062009
active transmembrane transporter activity	0.252733105474942	bayes_pls_golite062009
phosphatase binding	0.24515474358339	bayes_pls_golite062009
structural molecule activity	0.153277808949873	bayes_pls_golite062009
cytoskeletal protein binding	0.0187659836234897	bayes_pls_golite062009

No functions predicted.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.90

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..121]	PSI-BLAST	4.221849	Solution Structure of The forth PDZ Domain of Human Atrophin-1 Interacting Protein 1 (KIAA0705 Protein)
2	View Details	[122..182]	deduced	N/A	No confident structure predictions are available.
3	View Details	[183..293]	PSI-BLAST	3.39794	Solution structure of the fourth PDZ domain of KIAA1095 protein
4	View Details	[294..624]	PSI-BLAST	76.522879	No description for 2i75A was found.

Protein Overview: ptp-1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: