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Protein Overview: hsf-1

General Information:
Name(s) found: hsf-1 / CE22380 [WormBase]
Description(s) found:
Found 21 descriptions.
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  • WBGene00002004 locus:hsf-1 status:Confirmed UniProt:G5EFT5 protein_id:CAA22146.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 671 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    Biological Process: dauer larval development [IGILink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    hermaphrodite genitalia development [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    determination of adult lifespan [IGILink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed article]
    regulation of transcription, DNA-dependent [IEALink to PubMed article]
    gamete generation [IMPLink to PubMed article]
    growth [IMPLink to PubMed article]
    Molecular Function: transcription factor activity [IEALink to PubMed article]
    sequence-specific DNA binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQPTGNQIQQ NQQQQQQLIM RVPKQEVSVS GAARRYVQQA PPNRPPRQNH QNGAIGGKKS  60
   61 SVTIQEVPNN AYLETLNKSG NNKVDDDKLP VFLIKLWNIV EDPNLQSIVH WDDSGASFHI 120
  121 SDPYLFGRNV LPHFFKHNNM NSMVRQLNMY GFRKMTPLSQ GGLTRTESDQ DHLEFSHPCF 180
  181 VQGRPELLSQ IKRKQSARTV EDKQVNEQTQ QNLEVVMAEM RAMREKAKNM EDKMNKLTKE 240
  241 NRDMWTQMGS MRQQHARQQQ YFKKLLHFLV SVMQPGLSKR VAKRGVLEID FCAANGTAGP 300
  301 NSKRARMNSE EGPYKDVCDL LESLQRETQE PFSRRFTNNE GPLISEVTDE FGNSPVGRGS 360
  361 AQDLFGDTFG AQSSRYSDGG ATSSREQSPH PIISQPQSNS AGAHGANEQK PDDMYMGSGP 420
  421 LTHENIHRGI SALKRDYQGA SPASGGPSTS SSAPSGAGAG ARMAQKRAAP YKNATRQMAQ 480
  481 PQQDYSGGFV NNYSGFMPSD PSMIPYQPSH QYLQPHQKLM AIEDQHHPTT STSSTNADPH 540
  541 QNLYSPTLGL SPSFDRQLSQ ELQEYFTGTD TSLESFRDLV SNHNWDDFGN NVPLDDDEEG 600
  601 SEDPLRQLAL ENAPETSNYD GAEDLLFDNE QQYPENGFDV PDPNYLPLAD EEIFPHSPAL 660
  661 RTPSPSDPNL V

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..72] deduced N/A No confident structure predictions are available.
    2 View Details [73..273] PSI-BLAST 43.69897 SOLUTION STRUCTURE OF THE DNA-BINDING DOMAIN OF DROSOPHILA HEAT SHOCK TRANSCRIPTION FACTOR
    3 View Details [274..339] deduced N/A No confident structure predictions are available.
    4 View Details [340..517] MSA 2.244997 View MSA. No confident structure predictions are available.
    5 View Details [518..671] MSA 5.188991 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  3.77201910025409 bayes_pls_golite062009
  • binding
    		•  3.52874320222492 bayes_pls_golite062009
  • DNA binding
    		•  3.44642410378325 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.25777282180864 bayes_pls_golite062009
  • transcription factor activity
    		•  2.83460075788873 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.39237599101586 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.08341148210578 bayes_pls_golite062009
  • transcription activator activity
    		•  1.98504395280033 bayes_pls_golite062009
  • protein binding
    		•  0.753698599635855 bayes_pls_golite062009
  • transcription factor binding
    		•  0.63938506997853 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.49916895549368 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.0565989703351002 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle