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Protein Overview: nuo-5

General Information:
Name(s) found: nuo-5 / CE21933 [WormBase]
Description(s) found:
Found 20 descriptions.
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  • WBGene00021562 locus:nuo-5 status:Confirmed UniProt:Q9N4Y8 protein_id:CCD65491.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 729 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEALink to PubMed article]
    formate dehydrogenase complex [IEALink to PubMed article]
    Biological Process: electron transport [IEALink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed article]
    ATP synthesis coupled electron transport [IEALink to PubMed article]
    formate metabolic process [IEALink to PubMed article]
    growth [IMPLink to PubMed article]
    Molecular Function: oxidoreductase activity [IEALink to PubMed article]
    electron carrier activity [IEALink to PubMed article]
    molybdenum ion binding [IEALink to PubMed article]
    NADH dehydrogenase (ubiquinone) activity [IEALink to PubMed article]
    formate dehydrogenase activity [IEALink to PubMed article]
    dimethyl sulfoxide reductase activity [IEALink to PubMed article]
    oxidoreductase activity, acting on NADH or NADPH [IEALink to PubMed article]
    4 iron, 4 sulfur cluster binding [IEALink to PubMed article]
    iron-sulfur cluster binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHRVGGQIVR GVSKAQQKRS LSVAAPAPPK KVEVFIDDKK VLVDPGMTIL QACALVGVDI  60
   61 PRFCYHDRLS IAGNCRMCLV EVEKSVKPVA SCAMPVMNGM KVKTNSDFVK KAREGVMEFM 120
  121 LNNHPLDCPI CDQGGECDLQ DQAMNFGSDR GRLQSRFDGK RALEDKNIGP LVKTVMTRCI 180
  181 QCTRCVRFAN EVAAFPDFGT TGRGQDLQIG TYVEKFFASE LSGNIIDICP VGALTSKQYA 240
  241 FTARPWETRK TESVDVMDAT GSNIVLSHRT GELLRVIPKI NDDINEEWIG DQSRFAVDGL 300
  301 KVQRLLTPMI RGADGQLKPA TWEEALFTVA AKLRETPAEQ KAAVAGGLND VESLVALKDL 360
  361 FNRFNSENVM TEEEFPDVGS GGSDLRSNYV FNDGIASVEN ADAILLVGTN PRFEAPTLNA 420
  421 RIRKSFLYSD VQVGVIGAET ELTYEYDYLG ASAKAIDEIL AGKGDFAKIL SSATTPLIIV 480
  481 GAQALKGEAG AALLGKLQQL ADKLGSGKEV KVLNVLQRWA GQAGALDVGY KAGTAGIRKT 540
  541 PIKFLYLLGA DEGKVTKANL DPSAFVVYQG HHGDAGAEMA DVVLPGAAYT EKEGTYVNTE 600
  601 GRSQRAYPAV SPPGDARVDW KIIRAVSEVS GKSLPYSDLK EIRQRLNEIA PHLVRYRDLE 660
  661 ASPFVKQALQ LAQPTGSIDV DVSPVLRELS DYYQTNVISR YSRSMAQARK AAIENKTNPY 720
  721 AEEPVYARL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..729] PSI-BLAST 100.0 Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • NADH dehydrogenase activity
    		•  8.57020397959255 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  8.38566609923386 bayes_pls_golite062009
  • NADH dehydrogenase (ubiquinone) activity
    		•  8.21082857163161 bayes_pls_golite062009
  • NADH dehydrogenase (quinone) activity
    		•  7.52220758347541 bayes_pls_golite062009
  • oxidoreductase activity
    		•  7.16286065347789 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  7.03780998761655 bayes_pls_golite062009
  • formate dehydrogenase activity
    		•  4.68407412780362 bayes_pls_golite062009
  • 4 iron, 4 sulfur cluster binding
    		•  3.54243134597505 bayes_pls_golite062009
  • oxidoreduction-driven active transmembrane transporter activity
    		•  3.29174700910768 bayes_pls_golite062009
  • succinate dehydrogenase activity
    		•  3.27019699125535 bayes_pls_golite062009
  • electron carrier activity
    		•  2.86867645862628 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors
    		•  2.73204059194206 bayes_pls_golite062009
  • metal cluster binding
    		•  2.57357653703854 bayes_pls_golite062009
  • iron-sulfur cluster binding
    		•  2.57357653703854 bayes_pls_golite062009
  • nitrate reductase activity
    		•  2.20600951698793 bayes_pls_golite062009
  • catalytic activity
    		•  1.93875927205186 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor
    		•  1.87673954208357 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  1.84836110501265 bayes_pls_golite062009
  • oxidoreductase activity, acting on other nitrogenous compounds as donors
    		•  1.12492792673137 bayes_pls_golite062009
  • binding
    		•  1.0770649921334 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
    		•  0.737415967372169 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.614505320206825 bayes_pls_golite062009
  • ferrous iron binding
    		•  0.599635746381861 bayes_pls_golite062009
  • cation binding
    		•  0.292059992813768 bayes_pls_golite062009
  • metal ion binding
    		•  0.292059992813768 bayes_pls_golite062009
  • ion binding
    		•  0.285849308897776 bayes_pls_golite062009
  • protein binding
    		•  0.128023487683923 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle