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Protein Overview: dpl-1

General Information:
Name(s) found: dpl-1 / CE21197 [WormBase]
Description(s) found:
Found 23 descriptions.
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  • WBGene00001061 locus:dpl-1 Transcription factor dpl-1 status:Confirmed UniProt:Q22703 protein_id:CAA92699.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 598 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    transcription factor complex [IEALink to PubMed article]
    Biological Process: negative regulation of Ras protein signal transduction [IMPLink to PubMed article]
    negative regulation of S phase of mitotic cell cycle [IMPLink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    hermaphrodite genitalia development [IMPLink to PubMed article]
    negative regulation of transcription [TASLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed article]
    regulation of transcription, DNA-dependent [IEALink to PubMed article]
    gamete generation [IMPLink to PubMed article]
    programmed cell death [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: transcription factor activity [IEALink to PubMed article]
    transcription repressor activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNPTNYDPRI GQPAQSRPQV SLSMGRRIVQ MPTGLPRSYQ DESHNEPVGW DEPSGVGGSS  60
   61 GAGGQQSDKP TGLRHFSTKV CEKVKEKGLT NYNEVADELV ADYFQNNLIK QIDVVKQEYD 120
  121 MKNIRRRVYD ALNVLLAMNI ITKSKKDIRW IGLPASASQE ISRLEEEKSR REASISSKKQ 180
  181 ALEEMVLQIV SYKNLVERNR KNEHKNGRPE NDTVLHLPFL IINTDKEANV ECSVSSDKSE 240
  241 FLFSFDKKFE IHDDFEILKK LNLACSLETT NPTAEEVKTA KSFLPTLHQH YVDEIIANRK 300
  301 KVEAEKEEKR KQQQLIADQM SMNLSQAQYV EPTSSLAQMS YSSRFNRQLQ EHLINDGSED 360
  361 RSAAAGIMER DYDMDKNVNQ GSASRGPMYN TYSPQKIRAQ VNTPLQVPPV TKRYYVQKTQ 420
  421 GPMKHDMTPV VRTVNRPYST VPPDRRLSTG ATSVNSGPVK YYVPQGHQPM HQPVGQRYRV 480
  481 RPQQPQMSHM GQPHQVQQRV VYPAGSISGH QLQPGQRIVT QRIVAPGGPH PPGTIVRKVI 540
  541 RKIVVNNPKQ SPAQQVIQKK MMEQDMCTFE RKTEQPMTSA QAAALIQHPQ PEEYDYFQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-1 hcp1 IP from december2004 Cheeseman, I.M., et al. (2005)
    View Run hcp-2 hcp2 ip from december Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..171] PSI-BLAST 30.0 Cell cycle transcription factor DP-2
    2 View Details [172..330] PSI-BLAST 53.0 Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer
    3 View Details [331..395] deduced N/A No confident structure predictions are available.
    4 View Details [396..456] deduced N/A No confident structure predictions are available.
    5 View Details [457..598] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  3.98990675336286 bayes_pls_golite062009
  • DNA binding
    		•  3.4273272886116 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.07556180315429 bayes_pls_golite062009
  • transcription factor activity
    		•  2.80110428028438 bayes_pls_golite062009
  • binding
    		•  2.18911933843505 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.14577668739338 bayes_pls_golite062009
  • transcription activator activity
    		•  0.53294679084865 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.53285802828572 bayes_pls_golite062009
  • protein binding
    		•  0.035220363090062 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle