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View Structure Prediction Details

Protein: dpl-1
Organism: Caenorhabditis elegans
Length: 598 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for dpl-1.

Description E-value Query
Range
Subject
Range
gi|39589156, gi|... - gi|39589156|emb|CAE57889.1| Hypothetical protein CBG00935 [Caenorhabditis briggsae], gi|187038669|em...
gi|157748981 - gi|157748981|ref|XP_001678204.1| Hypothetical protein CBG00935 [Caenorhabditis briggsae AF16]
629.0 [0..1] [597..1]

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Predicted Domain #1
Region A:
Residues: [1-171]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNPTNYDPRI GQPAQSRPQV SLSMGRRIVQ MPTGLPRSYQ DESHNEPVGW DEPSGVGGSS  60
   61 GAGGQQSDKP TGLRHFSTKV CEKVKEKGLT NYNEVADELV ADYFQNNLIK QIDVVKQEYD 120
  121 MKNIRRRVYD ALNVLLAMNI ITKSKKDIRW IGLPASASQE ISRLEEEKSR R

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.0
Match: 1cf7B
Description: Cell cycle transcription factor DP-2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.98990675336286 bayes_pls_golite062009
DNA binding 3.4273272886116 bayes_pls_golite062009
nucleic acid binding 3.07556180315429 bayes_pls_golite062009
transcription factor activity 2.80110428028438 bayes_pls_golite062009
binding 2.18911933843505 bayes_pls_golite062009
transcription repressor activity 2.14577668739338 bayes_pls_golite062009
transcription activator activity 0.53294679084865 bayes_pls_golite062009
sequence-specific DNA binding 0.53285802828572 bayes_pls_golite062009
protein binding 0.035220363090062 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [172-330]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EASISSKKQA LEEMVLQIVS YKNLVERNRK NEHKNGRPEN DTVLHLPFLI INTDKEANVE  60
   61 CSVSSDKSEF LFSFDKKFEI HDDFEILKKL NLACSLETTN PTAEEVKTAK SFLPTLHQHY 120
  121 VDEIIANRKK VEAEKEEKRK QQQLIADQMS MNLSQAQYV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 53.0
Match: 2azeA
Description: Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [331-395]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EPTSSLAQMS YSSRFNRQLQ EHLINDGSED RSAAAGIMER DYDMDKNVNQ GSASRGPMYN  60
   61 TYSPQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [396-456]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KIRAQVNTPL QVPPVTKRYY VQKTQGPMKH DMTPVVRTVN RPYSTVPPDR RLSTGATSVN  60
   61 S

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [457-598]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GPVKYYVPQG HQPMHQPVGQ RYRVRPQQPQ MSHMGQPHQV QQRVVYPAGS ISGHQLQPGQ  60
   61 RIVTQRIVAP GGPHPPGTIV RKVIRKIVVN NPKQSPAQQV IQKKMMEQDM CTFERKTEQP 120
  121 MTSAQAAALI QHPQPEEYDY FQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle