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Protein Overview: tdc-1

General Information:
Name(s) found: tdc-1 / CE21011 [WormBase]
Description(s) found:
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  • WBGene00006562 locus:tdc-1 status:Confirmed UniProt:Q21087 protein_id:CAA88862.1 [WormBase]
  • pir||T23175 hypothetical protein K01C8.3 - Caenorhabditis elegans [NCBI NR]
  • gi|4038507|emb|CAA88862.1| C. elegans protein K01C8.3a, partially confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|17534817|ref|NP_495744.1| Tyrosine DeCarboxylase family member (tdc-1) [Caenorhabditis elegans] [NCBI NR]
  • [wormpep67.fasta]
  • CE21011 WBGene00006562 locus:tdc-1 aromatic-L-amino-acid decarboxylase status:Partially_confirmed TR:Q21087 protein_id:CAA88862.1 [wormpep150.fasta]
  • 21011 WBGene00006562 locus:tdc-1 aromatic-L-amino-acid decarboxylase status:Partially_confirmed TR:Q21087 protein_id:CAA88862.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • tyrosine DeCarboxylase, Aromatic amino acid deCarboxylase (tdc-1) [Caenorhabditis elegans]gi|4038507|emb|CAA88862.1| Hypothetical protein K01C8.3a [Caenorhabditis elegans]gi|7505056|pir||T23175 hypothetical protein K01C8.3 - Caenorhabditis elegans [nrdb_11152004_Chlamydomonas]
  • locus:tdc-1 aromatic-L-amino-acid decarboxylase status:Partially_confirmed TR:Q21087 protein_id:CAA88862.1 [wormpep115.fasta.reversed]
  • CE21011 aromatic-L-amino-acid decarboxylase status:Partially_confirmed TR:Q21087 protein_id:CAA88862.1 [wormpep80.hongbin]
  • CE21011 WBGene00006562 locus:tdc-1 aromatic-L-amino-acid decarboxylase status:Partially_confirmed UniProt:Q21087_CAEEL protein_id:CAA88862.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE21011 WBGene00006562 locus:tdc-1 aromatic-L-amino-acid decarboxylase status:Partially_confirmed UniProt:Q21087_CAEEL protein_id:CAA88862.1| [wormORF-contam.fasta]
  • Hypothetical protein K01C8.3a [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Tyrosin DeCarboxylase family member (tdc-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE21011 WBGene00006562 locus:tdc-1 aromatic-L-amino-acid decarboxylase status:Partially_confirmed UniProt:Q21087 protein_id:CAA88862.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE21011 WBGene00006562 locus:tdc-1 aromatic-L-amino-acid decarboxylase status:Confirmed UniProt:Q21087 protein_id:CAA88862.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE21011 WBGene00006562 locus:tdc-1 status:Confirmed UniProt:Q21087 protein_id:CAA88862.1 [wormpep246-ecoli-contam.fasta]
  • CE21011 WBGene00006562 locus:tdc-1 status:Confirmed UniProt:Q95ZS2 protein_id:CAA88862.1 Tyrosine decarboxylase [c_elegans-PRJNA13758-WS250-ecoli-contam.fasta]
  • Isoform of Q95ZS2, Isoform a of Tyrosine decarboxylase OS=Caenorhabditis elegans GN=tdc-1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 650 amino acids

    Gene Ontology:
    Cellular Component: neuronal cell body [IDALink to PubMed article]
    axon [IDALink to PubMed article]
    Biological Process: carboxylic acid metabolic process [IEALink to PubMed article]
    Molecular Function: pyridoxal phosphate binding [IEALink to PubMed article]
    carboxy-lyase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVYGLGEALK NLNSYCQERT TRIRNSLSPS RPSMSEATAT GSSSSSRAST TIPSTPNMDV  60
   61 TPTVEDPRQN DNNASGMTRD EFRQYGKETV DYIVDYLENI QKRRVVPAIE PGYLKDLIPS 120
  121 EAPNTPESFE SVMEDFEKLI MPGITHWQHP RFHAYFPAGN SFPSIIADML SDAIGCVGFS 180
  181 WAACPAMTEL ELIMLDWFGK MIGLPAEFLP LTENGKGGGV IQSSASECNF VTLLAARFEV 240
  241 MKELRQRFPF VEEGLLLSKL IAYCSKEAHS SVEKACMIGM VKLRILETDS KFRLRGDTLR 300
  301 NAIQEDRNLG LIPFFVSTTL GTTSCCSFDV LSEIGPICKE NELWLHVDAA YSGSAFICPE 360
  361 FRPLMNGIEY AMSFNTNPNK WLLINFDCST MWVRDRFKLT QALVVDPLYL QHSWMDKSID 420
  421 YRHWGIPLSR RFRSLKLWFV IRMYGIDGLQ KYIREHVRLA KKMETLLRAD AKFEIVNEVI 480
  481 MGLVCFRMKG DDELNQTLLT RLNASGRIHM VPASLGDRFV IRFCVCAENA TDKDIEVAYE 540
  541 IIAQATQHVL HDSVKAVIAE EDEEAVALEE MVADLNITET PEKCLTRQNS ANAAESGQKL 600
  601 ERQLSKEEIL AQKQHESLAK KRYTPQPLDL ALAPDSDPEL SPCSPQILVS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..557] PSI-BLAST 110.0 DOPA decarboxylase
    2 View Details [558..650] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • 4-aminobutyrate transaminase activity
    		•  2.49533238079952 bayes_pls_golite062009
  • catalytic activity
    		•  2.29878871754893 bayes_pls_golite062009
  • transferase activity, transferring nitrogenous groups
    		•  1.28316822767388 bayes_pls_golite062009
  • transaminase activity
    		•  1.24990480711889 bayes_pls_golite062009
  • 5-aminolevulinate synthase activity
    		•  1.01853440922526 bayes_pls_golite062009
  • transferase activity
    		•  0.737426388870721 bayes_pls_golite062009
  • binding
    		•  0.252160165096264 bayes_pls_golite062009
  • L-aspartate:2-oxoglutarate aminotransferase activity
    		•  0.130698724135981 bayes_pls_golite062009
  • carbon-carbon lyase activity
    		•  0.11598778799668 bayes_pls_golite062009
  • aromatic-L-amino-acid decarboxylase activity
    		•  0.10589462882093 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle