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Protein Overview: spl-1

General Information:
Name(s) found: spl-1 / CE20348 [WormBase]
Description(s) found:
Found 23 descriptions.
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  • WBGene00004981 locus:spl-1 Sphingosine-1-phosphate lyase status:Confirmed UniProt:Q9Y194 protein_id:CCD69676.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 552 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [IEALink to PubMed article]
    Biological Process: glutamate metabolic process [IEALink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed article]
    metabolic process [IEALink to PubMed article]
    carboxylic acid metabolic process [IEALink to PubMed article]
    Molecular Function: pyridoxal phosphate binding [IEALink to PubMed article]
    transaminase activity [IEALink to PubMed article]
    glutamate decarboxylase activity [IEALink to PubMed article]
    carboxy-lyase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSVKHTTEI IVDLTKMHYH MINDRLSRYD PVVLVLAAFG GTLVYTKVVH LYRKSEDPIL  60
   61 KRMGAYVFSL LRKLPAVRDK IEKELAAEKP KLIESIHKDD KDKQFISTLP IAPLSQDSIM 120
  121 ELAKKYEDYN TFNIDGGRVS GAVYTDRHAE HINLLGKIYE KYAFSNPLHP DVFPGARKME 180
  181 AELIRMVLNL YNGPEDSSGS VTSGGTESII MACFSYRNRA HSLGIEHPVI LACKTAHAAF 240
  241 DKAAHLCGMR LRHVPVDSDN RVDLKEMERL IDSNVCMLVG SAPNFPSGTI DPIPEIAKLG 300
  301 KKYGIPVHVD ACLGGFMIPF MNDAGYLIPV FDFRNPGVTS ISCDTHKYGC TPKGSSIVMY 360
  361 RSKELHHFQY FSVADWCGGI YATPTIAGSR AGANTAVAWA TLLSFGRDEY VRRCAQIVKH 420
  421 TRMLAEKIEK IKWIKPYGKS DVSLVAFSGN GVNIYEVSDK MMKLGWNLNT LQNPAAIHIC 480
  481 LTINQANEEV VNAFAVDLEK ICEELAAKGE QKADSGMAAM YGMAAQVPKS VVDEVIALYI 540
  541 DATYSAPPST SN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..552] PSI-BLAST 68.30103 DOPA decarboxylase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • C-palmitoyltransferase activity
    		•  4.27273846204139 bayes_pls_golite062009
  • serine C-palmitoyltransferase activity
    		•  4.27273846204139 bayes_pls_golite062009
  • catalytic activity
    		•  2.29878871754893 bayes_pls_golite062009
  • glutamate decarboxylase activity
    		•  1.34215658716536 bayes_pls_golite062009
  • transferase activity, transferring nitrogenous groups
    		•  1.28316822767388 bayes_pls_golite062009
  • transaminase activity
    		•  1.24990480711889 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
    		•  1.05524734914785 bayes_pls_golite062009
  • glycine dehydrogenase (decarboxylating) activity
    		•  1.05524734914785 bayes_pls_golite062009
  • transferase activity
    		•  0.737426388870721 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.691073358419788 bayes_pls_golite062009
  • binding
    		•  0.661198018681765 bayes_pls_golite062009
  • DNA binding
    		•  0.579562080072574 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.547593348248892 bayes_pls_golite062009
  • C-acyltransferase activity
    		•  0.46392133442786 bayes_pls_golite062009
  • transcription factor activity
    		•  0.352624414131738 bayes_pls_golite062009
  • N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
    		•  0.223759435414525 bayes_pls_golite062009
  • L-aspartate:2-oxoglutarate aminotransferase activity
    		•  0.13686553668007 bayes_pls_golite062009
  • 4-aminobutyrate transaminase activity
    		•  0.122706514261728 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.67

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle