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Protein Overview: mrg-1

General Information:
Name(s) found: mrg-1 / CE20213 [WormBase]
Description(s) found:
Found 18 descriptions.
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  • WBGene00003406 locus:mrg-1 status:Confirmed UniProt:Q9XWW2 protein_id:CAA21528.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 335 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    autosome [IDALink to PubMed article]
    chromatin [IEALink to PubMed article]
    Biological Process: germ cell development [IMPLink to PubMed article]
    negative regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    hermaphrodite genitalia development [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed article]
    post-embryonic body morphogenesis [IMPLink to PubMed article]
    chromatin assembly or disassembly [IEALink to PubMed article]
    gamete generation [IMPLink to PubMed articleLink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IGILink to PubMed article]
    reproduction [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: chromatin binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSKKNFEVG ENVACIYKGK PYDAKITDIK TNSDGKELYC VHFKGWNNRY DEKIPVGEEK  60
   61 DRIFKGTASE YAEKHNAELP TTALKPKKKS LAAEAPRDDR DDTPGTSKGK KAKSVTIAPV 120
  121 MTADDMKVEL PKPLRKILID DYDLVCRYFI NIVPHEYSVD QIIEDYIKTI PVSNEQMRTV 180
  181 DDLLIEYEEA DIKITNLALI CTARGLVDYF NVTLGYQLLY KFERPQYNDL VKKRAMEKGI 240
  241 DITNPTALQD SGFRPSQEYG IVHFLRMLAK LPDYLKLTQW NDHVINRIMI GVHDLIVFLN 300
  301 KNHGKYYRGS SDYQGASNDY YRRSLAADDG VGANQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..120] PSI-BLAST 18.522879 Solution Structure of the Tudor Domain from Mouse Hypothetical Protein Homologous to Histone Acetyltransferase
    2 View Details [121..335] PSI-BLAST 50.69897 Crystal Structure of the MRG15 MRG domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription repressor activity
    		•  4.08500855631983 bayes_pls_golite062009
  • chromatin binding
    		•  3.84065302930105 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.64390820819794 bayes_pls_golite062009
  • binding
    		•  3.06758476214113 bayes_pls_golite062009
  • protein binding
    		•  2.66728689880621 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.19167058827256 bayes_pls_golite062009
  • DNA binding
    		•  2.05514577638135 bayes_pls_golite062009
  • histone binding
    		•  2.00388175060339 bayes_pls_golite062009
  • transcription activator activity
    		•  1.46529895769882 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.10020047862576 bayes_pls_golite062009
  • methylated histone residue binding
    		•  1.03331560428208 bayes_pls_golite062009
  • general transcriptional repressor activity
    		•  0.75184432495983 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.294457188332415 bayes_pls_golite062009
  • catalytic activity
    		•  0.14067200158938 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle