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Protein Overview: hmp-2

General Information:
Name(s) found: hmp-2 / CE19974 [WormBase]
Description(s) found:
Found 21 descriptions.
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  • WBGene00001979 locus:hmp-2 Protein humpback-2 status:Confirmed UniProt:O44326 protein_id:CAB04572.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 678 amino acids

    Gene Ontology:
    Cellular Component: cell-cell adherens junction [IDALink to PubMed article]
    Biological Process: embryonic development [IMPLink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    morphogenesis of an epithelium [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    post-embryonic body morphogenesis [IMPLink to PubMed article]
    gastrulation with mouth forming first [IMPLink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IDALink to PubMed article]
    cell migration [IMPLink to PubMed article]
    cytoskeletal anchoring at plasma membrane [IMPLink to PubMed article]
    positive regulation of multicellular organism growth [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: alpha-catenin binding [IPILink to PubMed article]
    protein binding [IPILink to PubMed article]
    transcription coactivator activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLHSTNSYS IFTDHEVETR TSRIRSAMFP DWIPPTSAAE ATNSTTSIVE MMQMPTQQLK  60
   61 QSVMDLLTYE GSNDMSGLSL PDLVKLMCDH DESVVARAVH RAYMLSREDP NFFNAPGFDH 120
  121 RSFVEALMAA SKSSNVNVRR NAIGALSHMS EQRGGPLLIF RSGGLAEIIR MLYDSLESVV 180
  181 HYAVTTLRNL LMHVSDSRAQ ARALNAVEAL TPHLHKTNPK LLAQVADGLY FLLIDDAPSK 240
  241 ITFLSLLGPQ ILVSILREYS DHRKLIYTVV RCIRSLSVCP SNKPALISLG CLPALYVELC 300
  301 TAKDERSQTA ILVAMRNLSD SATNEENLTQ LIIKLLEIIR VANDGMTACA CGTLSNLTCN 360
  361 NTRNKQTVCS HGGIDALVTA IRRLPEVEEV TEPALCALRH CTARHSLAEE AQSELRFCQA 420
  421 FPVILDQLET LRTPVIKAAL GVIRNSALLQ TNLIELTQEQ TANGHTAVSL TMDILRRAIT 480
  481 AIEENPDIAV DGVPMWGVIE GAVSALHQLA NHPAVAAACC DDIGQVGNPE CPPFLDLLHR 540
  541 LLAHPRLGSM DDEVLEREIL GLLYQLSKRP DGARAVESTG VSALLMESRG SQYKSVVTYA 600
  601 NGVLSNLKRG DSAAIMNMSN SYDYEMSGSA ADWQRDGLER ELFAEMYPTN DGGHSESINM 660
  661 ALNNSQMRPN HNWYDTDL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..67] PSI-BLAST 6.0 A LEUCINE-RICH REPEAT VARIANT WITH A NOVEL REPETITIVE PROTEIN STRUCTURAL MOTIF
    2 View Details [68..609] PSI-BLAST 86.30103 beta-Catenin
    3 View Details [610..678] PSI-BLAST 18.69897 Importin beta

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  1.52869107451293 bayes_pls_golite062009
  • protein transporter activity
    		•  1.46178231098581 bayes_pls_golite062009
  • protein binding
    		•  0.91858015757355 bayes_pls_golite062009
  • transporter activity
    		•  0.53053318170156 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.11990405994399 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle