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Protein Overview: egl-4

General Information:
Name(s) found: egl-4 / CE19898 [WormBase]
Description(s) found:
Found 19 descriptions.
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  • WBGene00001173 locus:egl-4 cGMP-dependent protein kinase egl-4 status:Confirmed UniProt:O76360 protein_id:CCD71860.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 737 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    cAMP-dependent protein kinase complex [IEALink to PubMed article]
    Biological Process: signal transduction [IEALink to PubMed article]
    protein amino acid phosphorylation [IEALink to PubMed article]
    Molecular Function: ATP binding [IEALink to PubMed article]
    protein tyrosine kinase activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    non-membrane spanning protein tyrosine kinase activity [IEALink to PubMed article]
    protein kinase activity [IEALink to PubMed article]
    protein serine/threonine kinase activity [IEALink to PubMed article]
    cAMP-dependent protein kinase regulator activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKQQPPRIYV QVGTRTFEAH ELQKLIPQLE EAISRKDAQL RQQQTIVEGH IKRISELEGE  60
   61 VTTLQRECDK LRSVLEQKAQ SAASPGGQPP SPSPRTDQLG NDLQQKAVLP ADGVQRAKKI 120
  121 AVSAEPTNFE NKPATLQHYN KTVGAKQMIR DAVQKNDFLK QLAKEQIIEL VNCMYEMRAR 180
  181 AGQWVIQEGE PGDRLFVVAE GELQVSREGA LLGKMRAGTV MGELAILYNC TRTASVQALT 240
  241 DVQLWVLDRS VFQMITQRLG MERHSQLMNF LTKVSIFQNL SEDRISKMAD VMDQDYYDGG 300
  301 HYIIRQGEKG DAFFVINSGQ VKVTQQIEGE TEPREIRVLN QGDFFGERAL LGEEVRTANI 360
  361 IAQAPGVEVL TLDRESFGKL IGDLESLKKD YGDKERLAQV VREPPSPVKI VDDFREEFAQ 420
  421 VTLKNVKRLA TLGVGGFGRV ELVCVNGDKA KTFALKALKK KHIVDTRQQE HIFAERNIMM 480
  481 ETSTDWIVKL YKTFRDQKFV YMLLEVCLGG ELWTTLRDRG HFDDYTARFY VACVLEGLEY 540
  541 LHRKNIVYRD LKPENCLLAN TGYLKLVDFG FAKKLASGRK TWTFCGTPEY VSPEIILNKG 600
  601 HDQAADYWAL GIYICELMLG RPPFQASDPM KTYTLILKGV DALEIPNRRI GKTATALVKK 660
  661 LCRDNPGERL GSGSGGVNDI RKHRWFMGFD WEGLRSRTLK PPILPKVSNP ADVTNFDNYP 720
  721 PDNDVPPDEF SGWDEGF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-1 hcp1 IP from december2004 Cheeseman, I.M., et al. (2005)
    View Run hcp-2 hcp2 ip from december Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..98] PSI-BLAST 5.221849 Solution structure of the docking and dimerization domain of the type I alpha regulatory subunit of protein kinase A (RIalpha D/D)
    2 View Details [99..188] PSI-BLAST 44.69897 REGULATORY SUBUNIT OF CAMP DEPENDENT PROTEIN KINASE
    3 View Details [189..673] PSI-BLAST 44.30103 No description for 2ozoA was found.
    4 View Details [674..737] PSI-BLAST 86.69897 No description for 2gnfA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle