Protein Overview: nhr-80

General Information:
Name(s) found:	nhr-80 / CE19488 [WormBase]
Description(s) found: Found 19 descriptions. SHOW ALL	WBGene00003670 locus:nhr-80 status:Confirmed UniProt:Q8ITW8 protein_id:CCD68271.1 [WormBase]
Organism:	Caenorhabditis elegans
Length:	504 amino acids
Gene Ontology:
Cellular Component:	nucleus [IEA]
Biological Process:	embryonic development ending in birth or egg hatching [IMP ] positive regulation of growth rate [IMP] regulation of transcription, DNA-dependent [IEA] positive regulation of transcription from RNA polymerase II promoter [IMP] positive regulation of fatty acid metabolic process [IMP]
Molecular Function:	transcription factor activity [IEA] zinc ion binding [IEA] steroid hormone receptor activity [IEA] sequence-specific DNA binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTAEGRYLEI RKKTVKSKFR FPASSSSTRC LICSAQATGF HFEAQSCSAC AAFFRRTVAL  60
   61 TKSFKCITGR DDCNVHYSMH QICRSCRHKK CLSNGMKPGG VQPKKPNIET GRAFFTKSGL 120
  121 KRNKKFANVS PQTADEQKLV VEGVKVPKIE VQEPNSLEDL EQDNEFVIKT PTPRKISSST 180
  181 SFSASTTTNY STPGPSPMAP CSAGPDVLTL FIREEMKLGE RRRLLFSERA VGTLLGQNKH 240
  241 CPYKKEDIKP LVFHDFRLTI KTHIMLVYEW LQTWPELQEL DDFDRMSLLR KAVLIHFLLD 300
  301 PSFLSYQIGE PDKLIMQNGG FISTADHHGV GWEDETDISG ENKRKYYVPI MKQITDEIMP 360
  361 AMEAMKITFE EFVALKALAC FQGGFENVSE AKRHLITQQV NRIMTSLHTH YLENSEEKIA 420
  421 ERFGTIVLML SNIFTAGNDF VQNHREIDIF HIWDLDKLVL QLLNLDKIME TEARETAEKR 480
  481 AMRNGINVVN NNNDVLLGQA KLEK

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..141]	PSI-BLAST	21.045757	No description for 2hanB was found.
2	View Details	[142..504]	PSI-BLAST	44.522879	Crystal Structure of the RARbeta/RXRalpha Ligand Binding Domain Heterodimer in Complex with 9-cis Retinoic Acid and a Fragment of the TRAP220 Coactivator

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
transcription regulator activity	2.44628241003393	bayes_pls_golite062009
DNA binding	1.94519080035201	bayes_pls_golite062009
nucleic acid binding	1.85629109425119	bayes_pls_golite062009
protein binding	1.72653516930292	bayes_pls_golite062009
binding	1.62447538331668	bayes_pls_golite062009
transcription factor activity	1.37728257720121	bayes_pls_golite062009
transcription activator activity	1.10952708883226	bayes_pls_golite062009
sequence-specific DNA binding	0.78199243307321	bayes_pls_golite062009
catalytic activity	0.472235543748473	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.38848912999406	bayes_pls_golite062009

2

Term	Confidence	Notes
transcription regulator activity	3.96722324965091	bayes_pls_golite062009
DNA binding	3.25939553877631	bayes_pls_golite062009
nucleic acid binding	3.16396885393239	bayes_pls_golite062009
transcription activator activity	2.6892852470567	bayes_pls_golite062009
transcription factor activity	2.56099230851339	bayes_pls_golite062009
binding	2.51356324019445	bayes_pls_golite062009
protein binding	2.49676963514373	bayes_pls_golite062009
ligand-dependent nuclear receptor activity	2.20144353900307	bayes_pls_golite062009
sequence-specific DNA binding	2.1684625121246	bayes_pls_golite062009
signal transducer activity	1.57315744720763	bayes_pls_golite062009
molecular transducer activity	1.57315744720763	bayes_pls_golite062009
receptor activity	1.28597420456904	bayes_pls_golite062009
transcription factor binding	0.78455053961808	bayes_pls_golite062009
steroid hormone receptor activity	0.71366308307673	bayes_pls_golite062009
transcription repressor activity	0.49585672359082	bayes_pls_golite062009
catalytic activity	0.477341996033689	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.36233153809872	bayes_pls_golite062009
retinoic acid receptor activity	0.26050147400703	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.49

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle