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Protein Overview: CE18278

General Information:
Name(s) found: CE18278 [WormBase]
Description(s) found:
Found 19 descriptions.
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  • WBGene00011918 status:Partially_confirmed UniProt:Q22668 protein_id:CAA99930.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 591 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: protein amino acid dephosphorylation [IEALink to PubMed article]
    dephosphorylation [IEALink to PubMed article]
    Molecular Function: protein tyrosine phosphatase activity [IEALink to PubMed article]
    phosphatase activity [IEALink to PubMed article]
    cytoskeletal protein binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQRRKGTRGN SQDDQQASRR LAKKPSDEKV DEKDKKKGGV LKRLGFLLHN EKKEEVGSTQ  60
   61 KRRKPKRGTE RKRACSHPVW NPDKKIHFNN EKTHAIIPLK GDPLSDVQKK VFFKFASDAV 120
  121 KKNPPEYSVE FMTKVKPYPG QPMERKIFDA NPTKNRYKDV VCNDITRVIL SDGGDGDYIH 180
  181 ANYVNGLNAP FILTQGATAA TVIDFWRMVV HTKTAYIVML CEVMEDGKAK CAQYYPEKAG 240
  241 EAMTFGAWTI LCSLEDDKDA NIIKRTLSVR NVDNGKEHIL KHLHTKSWPD RCVPNSTMAL 300
  301 LRMLYIVRTA SGPVTVHCSA GIGRTGTFVA IEACLQILTD GKELDLLGTC RALRNSRAGS 360
  361 IQVDIQYMAL VQILINYGKD NGYWDDSDLD DRVELLTWNI QQFIQTRGKV DHVPTTPSTP 420
  421 ALNIIPADAK PVPVVPKEAT PHHSPAEKAQ ECMEKICEKI LKPIKKDKEC KEHKSPKTEH 480
  481 PKECKDHPLP LETRSSSEDG PDMEDQKTQA TQKVEIKEET AAQNDNISMI SLPNEPLLSI 540
  541 PVVRKNSKDG NKDSCDTKES KETKGHEKKN SKEGNFKLVK KQSANRSQYF L

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..95] PSI-BLAST 71.0 Tyrosine phosphatase; Tyrosine phoshatase shp-2
    2 View Details [96..489] PSI-BLAST 107.0 Crystal structure of the phosphatase domains of human PTP SIGMA
    3 View Details [490..591] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • insulin receptor binding
    		•  3.48393497211158 bayes_pls_golite062009
  • protein binding
    		•  3.19631993182765 bayes_pls_golite062009
  • binding
    		•  3.12724619324809 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  2.76609604594837 bayes_pls_golite062009
  • phosphatase activity
    		•  2.39617614358425 bayes_pls_golite062009
  • phosphoprotein phosphatase activity
    		•  2.32814368667748 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.22704087268457 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.85015570449703 bayes_pls_golite062009
  • kinase activity
    		•  1.78069536883109 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.59739467025045 bayes_pls_golite062009
  • protein kinase activity
    		•  1.4654611643382 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.38649262176488 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.33740973673697 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.28138694351561 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.2323381312171 bayes_pls_golite062009
  • transferase activity
    		•  1.19152443245584 bayes_pls_golite062009
  • DNA binding
    		•  1.17144894382542 bayes_pls_golite062009
  • phosphoinositide 3-kinase regulator activity
    		•  1.03150090191995 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.999269271132931 bayes_pls_golite062009
  • signal transducer activity
    		•  0.999269271132931 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  0.950445630788802 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • protein phosphorylated amino acid binding
    		•  0.649814096718101 bayes_pls_golite062009
  • transcription factor activity
    		•  0.573315212617741 bayes_pls_golite062009
  • receptor binding
    		•  0.460399756639525 bayes_pls_golite062009
  • phosphotyrosine binding
    		•  0.311079584914389 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  0.29798436765753 bayes_pls_golite062009
  • protein tyrosine phosphatase activity
    		•  0.251558977399574 bayes_pls_golite062009
  • protein complex binding
    		•  0.19242065162232 bayes_pls_golite062009
  • phosphoprotein binding
    		•  0.16798254471727 bayes_pls_golite062009
  • kinase regulator activity
    		•  0.10704587503284 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle