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Protein Overview: gale-1

General Information:
Name(s) found: gale-1 / CE17566 [WormBase]
Description(s) found:
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  • WBGene00008132 locus:gale-1 status:Confirmed UniProt:O62107 protein_id:CAB16861.1 [WormBase]
  • pir||T19989 hypothetical protein C47B2.6 - Caenorhabditis elegans [NCBI NR]
  • gi|71982035|ref|NP_001021051.1| UDP-GALactose 4-Epimerase family member (gale-1) [Caenorhabditis elegans] [NCBI NR]
  • gi|3874971|emb|CAB16861.1| C. elegans protein C47B2.6a, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • ref|NP_493274.1| UDP-glucose (37.7 kD) (1N569) [Caenorhabditis elegans] [NCBI NR]
  • [wormpep67.fasta]
  • CE17566 WBGene00008132 NAD dependant epimerase\/dehydratase family status:Confirmed TR:O62107 protein_id:CAB16861.1 [wormpep150.fasta]
  • 17566 WBGene00008132 NAD dependant epimerase\/dehydratase family status:Confirmed TR:O62107 protein_id:CAB16861.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • UDP-glucose (37.7 kD) (1N569) [Caenorhabditis elegans]gi|3874971|emb|CAB16861.1| Hypothetical protein C47B2.6 [Caenorhabditis elegans]gi|7497542|pir||T19989 hypothetical protein C47B2.6 - Caenorhabditis elegans [nrdb_11152004_Chlamydomonas]
  • NAD dependant epimerase\/dehydratase family status:Confirmed TR:O62107 protein_id:CAB16861.1 [wormpep115.fasta.reversed]
  • CE17566 NAD dependant epimerase\/dehydratase family status:Partially_confirmed TR:O62107 protein_id:CAB16861.1 [wormpep80.hongbin]
  • CE17566 WBGene00008132 locus:gale-1 NAD dependant epimerase\/dehydratase family status:Confirmed UniProt:O62107_CAEEL protein_id:CAB16861.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE17566 WBGene00008132 locus:gale-1 NAD dependant epimerase\/dehydratase family status:Confirmed UniProt:O62107_CAEEL protein_id:CAB16861.1| [wormORF-contam.fasta]
  • Hypothetical protein C47B2.6a [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • C47B2.6a [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE17566 WBGene00008132 locus:gale-1 NAD dependant epimerase\/dehydratase family status:Confirmed TR:O62107 protein_id:CAB16861.1 [WormBase_C-elegans_wp180_08-19-2007_reversed.fasta]
  • CE17566 WBGene00008132 locus:gale-1 NAD dependant epimerase\/dehydratase family status:Confirmed UniProt:O62107 protein_id:CAB16861.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE17566 WBGene00008132 locus:gale-1 status:Confirmed UniProt:O62107 protein_id:CAB16861.1 [wormpep246-ecoli-contam.fasta]
  • Isoform of Q564Q1, UDP-GALactose 4-Epimerase OS=Caenorhabditis elegans GN=gale-1 PE=1 SV=1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 347 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEALink to PubMed article]
    Biological Process: carbohydrate metabolic process [IEALink to PubMed article]
    nucleotide-sugar metabolic process [IEALink to PubMed article]
    extracellular polysaccharide biosynthetic process [IEALink to PubMed article]
    GDP-mannose metabolic process [IEALink to PubMed article]
    steroid biosynthetic process [IEALink to PubMed article]
    biosynthetic process [IEALink to PubMed article]
    galactose metabolic process [IEALink to PubMed article]
    cellular metabolic process [IEALink to PubMed article]
    Molecular Function: 3-beta-hydroxy-delta5-steroid dehydrogenase activity [IEALink to PubMed article]
    NADP or NADPH binding [IEALink to PubMed article]
    coenzyme binding [IEALink to PubMed article]
    catalytic activity [IEALink to PubMed article]
    UDP-glucose 4-epimerase activity [IEALink to PubMed article]
    steroid delta-isomerase activity [IEALink to PubMed article]
    dTDP-glucose 4,6-dehydratase activity [IEALink to PubMed article]
    L-aminoadipate-semialdehyde dehydrogenase activity [IEALink to PubMed article]
    ADP-glyceromanno-heptose 6-epimerase activity [IEALink to PubMed article]
    dTDP-4-dehydrorhamnose reductase activity [IEALink to PubMed article]
    GDP-mannose 4,6-dehydratase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHILVTGAAG FIGSHTVLEL LNSGYTVLCI DNFANAISDE HGNAISLKRV AQLTGKDVPF  60
   61 QNVDVCDEAA LEKVFSENKF DGIIHLAALK AVGESVAKPL QYYSNNLVAS LNLIQMCLKY 120
  121 NVKNFVFSSS ATVYGPPSEL PITEKSQTGQ GITNPYGQTK YMMEQILIDV GKANPEWNVV 180
  181 LLRYFNPVGA HKSGLIGEDP KGVPNNLMPY VSQVAIGKLP VLTIYGDQFD TVDGTGVRDY 240
  241 IHVVDLAKGH VKAFDRIKTV GNIGTEIYNL GTGVGYSVRQ MVDALKKVSG RDIPVKIGVP 300
  301 RPGDVASVYC DPSLAQEKLG WRAETGLEEM CADLWNWQTK NPQGFSA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..347] PSI-BLAST 92.09691 Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • UDP-glucose 4-epimerase activity
    		•  2.13934644118967 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  1.03956654822048 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.868888700854563 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  0.82673050487418 bayes_pls_golite062009
  • DNA binding
    		•  0.790382977752475 bayes_pls_golite062009
  • binding
    		•  0.784517759335365 bayes_pls_golite062009
  • alcohol dehydrogenase (NAD) activity
    		•  0.65743456407889 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.613310508772122 bayes_pls_golite062009
  • retinol dehydrogenase activity
    		•  0.48941662111046 bayes_pls_golite062009
  • transcription factor activity
    		•  0.11102650759187 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.67

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle