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Protein Overview: ife-3

General Information:
Name(s) found: ife-3 / CE17331 [WormBase]
Description(s) found:
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  • WBGene00002061 locus:ife-3 Eukaryotic translation initiation factor 4E-3 status:Confirmed UniProt:O61955 protein_id:CCD61786.1 [WormBase]
  • pir||T33281 hypothetical protein B0348.6 - Caenorhabditis elegans [NCBI NR]
  • gi|3913923|sp|O61955.1|IF4E3_CAEEL RecName: Full=Eukaryotic translation initiation factor 4E-3; Short=eIF-4E-3; Short=eIF4E-3; AltName: Full=mRNA cap-binding protein; AltName: Full=eIF-4F 25 kDa subunit [NCBI NR]
  • gi|3168956|gb|AAC17807.1| Initiation factor 4e (eif4e) family protein 3, isoform a [Caenorhabditis elegans] [NCBI NR]
  • gi|17557342|ref|NP_503124.1| Initiation Factor 4E (eIF4E) family member (ife-3) [Caenorhabditis elegans] [NCBI NR]
  • (O61955) Eukaryotic translation initiation factor 4E-3 (eIF4E-3) (eIF-4E-3) (mRNA cap-binding protein) (eIF-4F 25 kDa subunit) [Swiss-Prot]
  • Eukaryotic translation initiation factor 4E-3 OS=Caenorhabditis elegans GN=ife-3 PE=1 SV=1 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE17331 WBGene00002061 locus:ife-3 translation initiation factor status:Confirmed SW:O61955 protein_id:AAC17807.1 [wormpep150.fasta]
  • 17331 WBGene00002061 locus:ife-3 translation initiation factor status:Partially_confirmed SW:O61955 protein_id:AAC17807.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • translation Initiation Factor 4E eIF4E (ife-3) [Caenorhabditis elegans]gi|3168956|gb|AAC17807.1| Initiation factor 4e (eif4e) family protein 3, isoform a [Caenorhabditis elegans]gi|7494884|pir||T33281 hypothetical protein B0348.6 - Caenorhabditis elegan [nrdb_11152004_Chlamydomonas]
  • CE17331 WBGene00002061 locus:ife-3 translation initiation factor status:Partially_confirmed SW:O61955 protein_id:AAC17807.1 [wormpep132.fasta]
  • 17331 WBGene00002061 locus:ife-3 translation initiation factor status:Confirmed SW:O61955 protein_id:AAC17807.1 [wormpep150-phg-orf-ecoli-rand.fasta]
  • locus:ife-3 translation initiation factor status:Partially_confirmed SW:O61955 protein_id:AAC17807.1 [wormpep115.fasta.reversed]
  • CE17331 translation initiation factor status:Partially_confirmed SW:O61955 protein_id:AAC17807.1 [wormpep80.hongbin]
  • CE17331 WBGene00002061 locus:ife-3 translation initiation factor status:Confirmed UniProt:O61955 protein_id:AAC17807.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE17331 WBGene00002061 locus:ife-3 translation initiation factor status:Confirmed UniProt:O61955 protein_id:AAC17807.1| [wormORF-contam.fasta]
  • Initiation Factor 4E (eIF4E) family member (ife-3) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Eukaryotic translation initiation factor 4E-3 (eIF4E-3) (eIF-4E-3) (mRNA cap-binding protein) (eIF-4F 25 kDa subunit) [nr-271106-contam.fasta]
  • Initiation factor 4e (eif4e) family protein 3, isoform a [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE17331 WBGene00002061 locus:ife-3 translation initiation factor status:Confirmed UniProt:O61955 protein_id:CCD61786.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE17331 WBGene00002061 locus:ife-3 status:Confirmed UniProt:O61955 protein_id:CCD61786.1 Eukaryotic translation initiation factor 4E-3 [wormpep246-ecoli-contam.fasta]
  • Isoform of O61955, Isoform b of Eukaryotic translation initiation factor 4E-3 OS=Caenorhabditis elegans GN=ife-3 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 248 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    Biological Process: embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    translational initiation [IEALink to PubMed article]
    Molecular Function: translation initiation factor activity [IEALink to PubMed article]
    RNA binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTSVAENKA LSASGDVNAS DASVPPELLT RHPLQNRWAL WYLKADRNKE WEDCLKMVSL  60
   61 FDTVEDFWSL YNHIQSAGGL NWGSDYYLFK EGIKPMWEDV NNVQGGRWLV VVDKQRRTQL 120
  121 LDHYWLELLM AIVGEQFDEY GDYICGAVVN VRQKGDKVSL WTRDATRDDV NLRIGQVLKQ 180
  181 KLSIPDTEIL RYEVHKDSSA RTSSTVKPRI CLPAKDPAPV KEKGPAATTS PSNPGTEATG 240
  241 TSPATPTP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..248] PSI-BLAST 82.0 Translation initiation factor eIF4e

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • translation initiation factor activity
    		•  12.6022960879923 bayes_pls_golite062009
  • RNA cap binding
    		•  8.70938037002519 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  7.91586572659635 bayes_pls_golite062009
  • translation regulator activity
    		•  7.87578736455963 bayes_pls_golite062009
  • RNA binding
    		•  6.31187636707846 bayes_pls_golite062009
  • binding
    		•  3.48071223822752 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.46353214508261 bayes_pls_golite062009
  • protein binding
    		•  0.850113401405075 bayes_pls_golite062009
  • RNA 7-methylguanosine cap binding
    		•  0.544036568660606 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle