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Protein Overview: lin-11

General Information:
Name(s) found: lin-11 / CE15150 [WormBase]
Description(s) found:
Found 22 descriptions.
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  • WBGene00003000 locus:lin-11 Protein lin-11 status:Confirmed UniProt:P20154 protein_id:CAB02310.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 405 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    Biological Process: positive regulation of vulval development [IMPLink to PubMed articleLink to PubMed article]
    regulation of cell differentiation [IMPLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed article]
    oviposition [IMPLink to PubMed article]
    regulation of transcription, DNA-dependent [IEALink to PubMed article]
    cell fate specification [IMPLink to PubMed article]
    regulation of cell migration [IMPLink to PubMed article]
    axonal fasciculation [IMPLink to PubMed article]
    Molecular Function: transcription factor activity [IEALink to PubMed article][ISSLink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    sequence-specific DNA binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHSSSSFIIT SLEEEEKKPP AHHLHQQSIE DVGSVTSSAT LLLLDSATWM MPSSTTQPHI  60
   61 SEISGNECAA CAQPILDRYV FTVLGKCWHQ SCLRCCDCRA PMSMTCFSRD GLILCKTDFS 120
  121 RRYSQRCAGC DGKLEKEDLV RRARDKVFHI RCFQCSVCQR LLDTGDQLYI MEGNRFVCQS 180
  181 DFQTATKTST PTSIHRPVSN GSECNSDVEE DNVDACDEVG LDDGEGDCGK DNSDDSNSAK 240
  241 RRGPRTTIKA KQLETLKNAF AATPKPTRHI REQLAAETGL NMRVIQVWFQ NRRSKERRMK 300
  301 QLRFGGYRQS RRPRRDDIVD MFPNDQQFYP PPPPSNVQFF CDPYTTSPNN PETIQMAPQF 360
  361 AVPTENMNMV PEPYTEQSAT PPEFNEDTFA CIYSTDLGKP TPVSW

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..111] PSI-BLAST 6.0 Cysteine-rich (intestinal) protein, CRP, CRIP
    2 View Details [112..239] PSI-BLAST 19.39794 No description for 2dfyX was found.
    3 View Details [240..310] PSI-BLAST 6.39794 DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM DROSOPHILA IN SOLUTION BY 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
    4 View Details [311..405] MSA 4.235997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  4.00967542385368 bayes_pls_golite062009
  • DNA binding
    		•  3.60745514727532 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.47256374293954 bayes_pls_golite062009
  • binding
    		•  2.96409924710655 bayes_pls_golite062009
  • transcription activator activity
    		•  2.9532663930699 bayes_pls_golite062009
  • transcription factor activity
    		•  2.90769972671972 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.72967350701574 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  2.55186574506963 bayes_pls_golite062009
  • protein binding
    		•  2.44501340584871 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.40923942043513 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  1.49515149729803 bayes_pls_golite062009
  • transcription factor binding
    		•  1.38523780690867 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.26452462867497 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.61572149323953 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.58115018700114 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.525229083081488 bayes_pls_golite062009
  • transporter activity
    		•  0.360646382536943 bayes_pls_golite062009
  • structural molecule activity
    		•  0.281585397269403 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.256420113528322 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.136251593831139 bayes_pls_golite062009
  • catalytic activity
    		•  0.101795606736461 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.5139760613123 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.16896789933192 bayes_pls_golite062009
  • transcription activator activity
    		•  3.10621734076555 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • protein binding
    		•  1.88087411289001 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.73068440195944 bayes_pls_golite062009
  • chromatin binding
    		•  1.68956710349366 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.62096064323298 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.2679415219517 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle