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Protein Overview: let-92

General Information:
Name(s) found: let-92 / CE10074 [WormBase]
Description(s) found:
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  • WBGene00002363 locus:let-92 Serine\/threonine-protein phosphatase status:Confirmed UniProt:G5EGK8 protein_id:CAB01174.1 [WormBase]
  • pir||T21975 phosphoprotein phosphatase (EC 3.1.3.16) 2A F38H4.9 [similarity] - Caenorhabditis elegans [NCBI NR]
  • gi|3876895|emb|CAB01174.1| C. elegans protein F38H4.9, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|17540308|ref|NP_502247.1| LEThal family member (let-92) [Caenorhabditis elegans] [NCBI NR]
  • [wormpep67.fasta]
  • CE10074 WBGene00002363 locus:let-92 serine\/threonine protein phosphatase status:Confirmed TR:Q27498 protein_id:CAB01174.1 [wormpep150.fasta]
  • 10074 WBGene00002363 locus:let-92 serine\/threonine protein phosphatase status:Confirmed TR:Q27498 protein_id:CAB01174.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • protein phosphatase catalytic (36.3 kD) (4M623) [Caenorhabditis elegans]gi|3876895|emb|CAB01174.1| Hypothetical protein F38H4.9 [Caenorhabditis elegans]gi|7500830|pir||T21975 phosphoprotein phosphatase (EC 3.1.3.16) 2A F38H4.9 [similarity] - Caenorhabdi [nrdb_11152004_Chlamydomonas]
  • locus:let-92 serine\/threonine protein phosphatase status:Confirmed TR:Q27498 protein_id:CAB01174.1 [wormpep115.fasta.reversed]
  • CE10074 serine\/threonine protein phosphatase status:Confirmed TR:Q27498 protein_id:CAB01174.1 [wormpep80.hongbin]
  • CE10074 WBGene00002363 locus:let-92 serine\/threonine protein phosphatase status:Confirmed UniProt:Q27498_CAEEL protein_id:CAB01174.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE10074 WBGene00002363 locus:let-92 serine\/threonine protein phosphatase status:Confirmed UniProt:Q27498_CAEEL protein_id:CAB01174.1| [wormORF-contam.fasta]
  • Hypothetical protein F38H4.9 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • LEThal family member (let-92) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE10074 WBGene00002363 locus:let-92 serine\/threonine protein phosphatase status:Confirmed UniProt:Q27498 protein_id:CAB01174.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE10074 WBGene00002363 locus:let-92 serine\/threonine protein phosphatase status:Confirmed UniProt:G5EGK8 protein_id:CAB01174.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE10074 WBGene00002363 locus:let-92 status:Confirmed UniProt:G5EGK8 protein_id:CAB01174.1 Serine\/threonine-protein phosphatase [wormpep246-ecoli-contam.fasta]
  • Serine/threonine-protein phosphatase OS=Caenorhabditis elegans GN=let-92 PE=1 SV=1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 318 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    cytoplasm [IEALink to PubMed article]
    Biological Process: embryonic cleavage [IMPLink to PubMed article]
    positive regulation of vulval development [IMPLink to PubMed article]
    detection of stimulus involved in sensory perception [IEALink to PubMed article]
    nematode larval development [IMPLink to PubMed articleLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    protein amino acid dephosphorylation [IEALink to PubMed article]
    cytokinesis [IMPLink to PubMed article]
    reproduction [IMPLink to PubMed article]
    Molecular Function: phosphoprotein phosphatase activity [IEALink to PubMed article]
    DEAD/H-box RNA helicase binding [IPILink to PubMed article]
    iron ion binding [IEALink to PubMed article]
    calcium ion binding [IEALink to PubMed article]
    manganese ion binding [IEALink to PubMed article]
    hydrolase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAAPPSADP LDKALIVDVD QWIEQLYECK PLSENQVKTL CEKAKEILEK EPNVQEVRCP  60
   61 VTVCGDVHGQ FHDLMELFKM GGKSPDTNYL FMGDYVDRGY YSVETVSLLV CLKIRYKDRV 120
  121 TLLRGNHESR QITQVYGFYD ECLRKYGNSN VWKYFTDLFD CFPLTALVDG QIFCLHGGLS 180
  181 PSIDTLDHIR ALDRIQEVPH EGPMCDLLWS DPDDRGGWGI SPRGAGYTFG QDISETFNHS 240
  241 NGLTLISRAH QLVMEGYNWS HDRNVVTVFS APNYCYRCGN QAAMVELDDD LKYSFLQFDP 300
  301 APRRGEPHVT RRTPDYFL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-1 hcp1 IP from december2004 Cheeseman, I.M., et al. (2005)
    View Run hcp-2 hcp2 ip from december Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..318] PSI-BLAST 104.0 No description for 2ie4C was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  11.6417995308386 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  10.6440947462013 bayes_pls_golite062009
  • phosphatase activity
    		•  10.5525832502704 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  10.3702645338723 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  9.02791306892273 bayes_pls_golite062009
  • calcium-dependent protein serine/threonine phosphatase activity
    		•  6.04386346716682 bayes_pls_golite062009
  • myosin phosphatase activity
    		•  5.31703100176823 bayes_pls_golite062009
  • hydrolase activity
    		•  3.13006743434485 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.68552051869632 bayes_pls_golite062009
  • kinase activity
    		•  1.67788383575784 bayes_pls_golite062009
  • structural molecule activity
    		•  1.5850868178597 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.57807175808088 bayes_pls_golite062009
  • protein kinase activity
    		•  1.4514460578232 bayes_pls_golite062009
  • binding
    		•  1.44538582463569 bayes_pls_golite062009
  • catalytic activity
    		•  1.39852585255405 bayes_pls_golite062009
  • transferase activity
    		•  1.3407391509244 bayes_pls_golite062009
  • protein binding
    		•  1.33435965029646 bayes_pls_golite062009
  • transporter activity
    		•  1.24767072239634 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.08090214431427 bayes_pls_golite062009
  • signal transducer activity
    		•  1.08090214431427 bayes_pls_golite062009
  • calmodulin binding
    		•  0.77173071932406 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.66803085638835 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.528189469950839 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.126411744957937 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle