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Protein Overview: atx-3

General Information:
Name(s) found: atx-3 / CE09760 [WormBase]
Description(s) found:
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  • WBGene00006446 locus:atx-3 Ataxin-3 homolog status:Confirmed UniProt:O17850 protein_id:CAB03016.1 [WormBase]
  • pir||T21511 hypothetical protein F28F8.6 - Caenorhabditis elegans [NCBI NR]
  • gi|3876468|emb|CAB03016.1| C. elegans protein F28F8.6, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|29427558|sp|O17850.1|ATX3_CAEEL RecName: Full=Ataxin-3 homolog; AltName: Full=Machado-Joseph disease-like protein [NCBI NR]
  • gi|17560316|ref|NP_506873.1| human ATX (ataxin) related family member (atx-3) [Caenorhabditis elegans] [NCBI NR]
  • (O17850) Machado-Joseph disease-like protein [Swiss-Prot]
  • Ataxin-3 homolog OS=Caenorhabditis elegans GN=atx-3 PE=1 SV=1 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE09760 WBGene00006446 locus:atx-3 Human Machedo-Joseph disease protein 1 like status:Partially_confirmed SW:O17850 protein_id:CAB03016.1 [wormpep150.fasta]
  • 09760 WBGene00006446 locus:tag-70 Human Machedo-Joseph disease protein 1 like status:Partially_confirmed SW:O17850 protein_id:CAB03016.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • Machado-Joseph disease like (35.9 kD) (5Q56) [Caenorhabditis elegans]gi|3876468|emb|CAB03016.1| Hypothetical protein F28F8.6 [Caenorhabditis elegans]gi|7500093|pir||T21511 hypothetical protein F28F8.6 - Caenorhabditis elegansgi|29427558|sp|O17850|MJDL_ [nrdb_11152004_Chlamydomonas]
  • CE09760 WBGene00006446 locus:tag-70 Human Machedo-Joseph disease protein 1 like status:Partially_confirmed SW:O17850 protein_id:CAB03016.1 [wormpep132.fasta]
  • 09760 WBGene00006446 locus:atx-3 Human Machedo-Joseph disease protein 1 like status:Partially_confirmed SW:O17850 protein_id:CAB03016.1 [wormpep150-phg-orf-ecoli-rand.fasta]
  • Human Machedo-Joseph disease protein 1 like status:Partially_confirmed SW:O17850 protein_id:CAB03016.1 [wormpep115.fasta.reversed]
  • CE09760 Human Machedo-Joseph disease protein 1 like status:Partially_confirmed TR:O17850 protein_id:CAB03016.1 [wormpep80.hongbin]
  • CE09760 WBGene00006446 locus:atx-3 Human Machedo-Joseph disease protein 1 like status:Confirmed UniProt:O17850 protein_id:CAB03016.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE09760 WBGene00006446 locus:atx-3 Human Machedo-Joseph disease protein 1 like status:Confirmed UniProt:O17850 protein_id:CAB03016.1| [wormORF-contam.fasta]
  • Hypothetical protein F28F8.6 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Ataxin-3 homolog (Machado-Joseph disease-like protein) [nr-271106-contam.fasta]
  • human ATX (ataxin) related family member (atx-3) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE09760 WBGene00006446 locus:atx-3 Human Machedo-Joseph disease protein 1 like status:Confirmed SW:O17850 protein_id:CAB03016.1 [WormBase_C-elegans_wp180_08-19-2007_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE09760 WBGene00006446 locus:atx-3 status:Confirmed UniProt:O17850 protein_id:CAB03016.1 Ataxin-3 homolog [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 317 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: embryonic development ending in birth or egg hatching [IMPLink to PubMed article]
    synaptic transmission [IMPLink to PubMed article]
    regulation of transcription [IEPLink to PubMed article]
    Molecular Function: ubiquitin-specific protease activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKDDPINSI FFEHQEAALC AQHALNMLLQ DALYKWQDLR DLAIQMDKME QQILGNANPT  60
   61 PGRSENMNES GYFSIQVLEK ALETFSLKLT NIENPAMVDY KNNPLTARAY ICNLREHWFV 120
  121 LRKFGNQWFE LNSVNRGPKL LSDTYVSMFL HQVSSEGYSI FVVQGVLPRS DADDLISLCP 180
  181 VVPPKVTPKK EQKLEKVMTK FFNTVGKRLG GGSGAPPDSQ EEKDLAIAFA MSMETKDGSE 240
  241 VSRSSAEIDE ENLRKAIELS QAPGPSEPAE IPLLTRSRSS TPPGASEPFS NAEQQRRDRQ 300
  301 KFLERFEKKK EERNDEK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..183] PSI-BLAST 80.154902 De-ubiquitinating function of ataxin-3: insights from the solution structure of the Josephin domain
    2 View Details [184..317] MSA 3.023989 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle