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Protein Overview: pcm-1

General Information:
Name(s) found: pcm-1 / CE08070 [WormBase]
Description(s) found:
Found 23 descriptions.
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  • WBGene00003954 locus:pcm-1 Protein-L-isoaspartate O-methyltransferase status:Confirmed UniProt:Q27873 protein_id:CCD64125.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 225 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    cytosol [IDA]
    Biological Process: embryonic development ending in birth or egg hatching [IMPLink to PubMed article]
    protein modification process [IEALink to PubMed article]
    cobalamin biosynthetic process [IEALink to PubMed article]
    Molecular Function: protein methyltransferase activity [IEALink to PubMed article]
    protein-L-isoaspartate (D-aspartate) O-methyltransferase activity [IEALink to PubMed article]
    methyltransferase activity [IEALink to PubMed article]
    S-adenosylmethionine-dependent methyltransferase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAWRSSGSTN SELIDNLRNN RVFASQRAYD AMKSVDRGDF APRAPYEDAP QRIGYNATVS  60
   61 APHMHAAALD YLQNHLVAGA KALDVGSGSG YLTVCMAMMV GRNGTVVGIE HMPQLVELSE 120
  121 KNIRKHHSEQ LERGNVIIIE GDGRQGFAEK APYNAIHVGA ASKGVPKALT DQLAEGGRMM 180
  181 IPVEQVDGNQ VFMQIDKING KIEQKIVEHV IYVPLTSREE QWNRN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-1 hcp1 IP from december2004 Cheeseman, I.M., et al. (2005)
    View Run hcp-2 hcp2 ip from december Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..225] PSI-BLAST 41.39794 Protein-L-isoaspartyl O-methyltransferase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein methyltransferase activity
    		•  5.03267617653315 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  4.4632173842967 bayes_pls_golite062009
  • methyltransferase activity
    		•  4.15445027778357 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  4.07806017452628 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  4.07153733729662 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  3.97658336148086 bayes_pls_golite062009
  • protein-arginine N-methyltransferase activity
    		•  3.26663548517117 bayes_pls_golite062009
  • arginine N-methyltransferase activity
    		•  3.26663548517117 bayes_pls_golite062009
  • transferase activity
    		•  2.926540904444 bayes_pls_golite062009
  • histone-arginine N-methyltransferase activity
    		•  2.86617323549909 bayes_pls_golite062009
  • protein-arginine omega-N monomethyltransferase activity
    		•  2.48017990451667 bayes_pls_golite062009
  • O-methyltransferase activity
    		•  2.46301422147246 bayes_pls_golite062009
  • protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
    		•  2.27866575945018 bayes_pls_golite062009
  • DNA-methyltransferase activity
    		•  2.18991764495147 bayes_pls_golite062009
  • histone methyltransferase activity (H4-R3 specific)
    		•  1.91133457052099 bayes_pls_golite062009
  • protein-arginine omega-N asymmetric methyltransferase activity
    		•  1.69391860928068 bayes_pls_golite062009
  • catalytic activity
    		•  1.25333584501255 bayes_pls_golite062009
  • protein-arginine omega-N symmetric methyltransferase activity
    		•  1.15089820497406 bayes_pls_golite062009
  • DNA binding
    		•  1.11249468705987 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.08316818833182 bayes_pls_golite062009
  • binding
    		•  0.976078016260105 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.908932475461063 bayes_pls_golite062009
  • RNA methyltransferase activity
    		•  0.817509452491588 bayes_pls_golite062009
  • thiopurine S-methyltransferase activity
    		•  0.74333485845978 bayes_pls_golite062009
  • site-specific DNA-methyltransferase (adenine-specific) activity
    		•  0.703178429468566 bayes_pls_golite062009
  • protein-lysine N-methyltransferase activity
    		•  0.469870476227704 bayes_pls_golite062009
  • lysine N-methyltransferase activity
    		•  0.469870476227704 bayes_pls_golite062009
  • histone-lysine N-methyltransferase activity
    		•  0.469870476227704 bayes_pls_golite062009
  • rRNA methyltransferase activity
    		•  0.230719796976667 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle