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Protein Overview: ace-1

General Information:
Name(s) found: ace-1 / CE07569 [WormBase]
Description(s) found:
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  • WBGene00000035 locus:ace-1 Acetylcholinesterase 1 status:Confirmed UniProt:P38433 protein_id:CCD68912.1 [WormBase]
  • gi|671831|emb|CAA53080.1| acetylcholinesterase [Caenorhabditis elegans] [NCBI NR]
  • pir||A54413 acetylcholinesterase (EC 3.1.1.7) A precursor - Caenorhabditis elegans [NCBI NR]
  • gi|584715|sp|P38433.1|ACE1_CAEEL RecName: Full=Acetylcholinesterase 1; Short=AChE 1; Flags: Precursor [NCBI NR]
  • gi|17548187|ref|NP_510660.1| abnormal ACEtylcholinesterase family member (ace-1) [Caenorhabditis elegans] [NCBI NR]
  • gi|1326277|gb|AAB00593.1| Abnormal acetylcholinesterase protein 1 [Caenorhabditis elegans] [NCBI NR]
  • Acetylcholinesterase 1 OS=Caenorhabditis elegans GN=ace-1 PE=1 SV=1 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE07569 WBGene00000035 locus:ace-1 status:Confirmed SW:P38433 protein_id:AAB00593.1 [wormpep150.fasta]
  • 07569 WBGene00000035 locus:ace-1 status:Confirmed SW:P38433 protein_id:AAB00593.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • abnormal ACEtylcholinesterase ACE-1, acetylcholinesterase class A precursor (71.4 kD) (ace-1) [Caenorhabditis elegans]gi|1326277|gb|AAB00593.1| Abnormal acetylcholinesterase protein 1 [Caenorhabditis elegans]gi|671831|emb|CAA53080.1| acetylcholinesteras [nrdb_11152004_Chlamydomonas]
  • locus:ace-1 status:Confirmed SW:P38433 protein_id:AAB00593.1 [wormpep115.fasta.reversed]
  • CE07569 locus:ace-1 status:Confirmed [wormpep80.hongbin]
  • CE07569 WBGene00000035 locus:ace-1 status:Confirmed UniProt:P38433 protein_id:AAB00593.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE07569 WBGene00000035 locus:ace-1 status:Confirmed UniProt:P38433 protein_id:AAB00593.1| [wormORF-contam.fasta]
  • Abnormal acetylcholinesterase protein 1 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • acetylcholinesterase [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Acetylcholinesterase 1 precursor (AChE 1) [nr-271106-contam.fasta]
  • abnormal ACEtylcholinesterase family member (ace-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE07569 WBGene00000035 locus:ace-1 status:Confirmed UniProt:P38433 protein_id:CCD68912.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE07569 WBGene00000035 locus:ace-1 status:Confirmed UniProt:P38433 protein_id:CCD68912.1 Acetylcholinesterase 1 [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 620 amino acids

    Gene Ontology:
    Cellular Component: cell [IDALink to PubMed article]
    insoluble fraction [IDALink to PubMed article]
    extracellular region [IDALink to PubMed article]
    Biological Process: acetylcholine catabolic process [IDALink to PubMed articleLink to PubMed article][IMPLink to PubMed article]
    regulation of locomotion [IGILink to PubMed articleLink to PubMed article]
    acetylcholine catabolic process in synaptic cleft [ISSLink to PubMed article]
    Molecular Function: identical protein binding [IPILink to PubMed articleLink to PubMed article]
    acetylcholinesterase activity [IDALink to PubMed articleLink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRNSLLFFIF LPSTILAVDL IHLHDGSPLF GEEVLSQTGK PLTRFQGIPF AEPPVGNLRF  60
   61 KKPKPKQPWR IPLNATTPPN SCIQSEDTYF GDFYGSTMWN ANTKLSEDCL YLNVYVPGKV 120
  121 DPNKKLAVMV WVYGGGFWSG TATLDVYDGR ILTVEENVIL VAMNYRVSIF GFLYMNRPEA 180
  181 PGNMGMWDQL LAMKWVHKNI DLFGGDLSRI TLFGESAGAA SVSIHMLSPK SAPYFHRAII 240
  241 QSGSATSPWA IEPRDVALAR AVILYNAMKC GNMSLINPDY DRILDCFQRA DADALRENEW 300
  301 APVREFGDFP WVPVVDGDFL LENAQTSLKQ GNFKKTQLLA GSNRDESIYF LTYQLPDIFP 360
  361 VADFFTKTDF IKDRQLWIKG VKDLLPRQIL KCQLTLAAVL HEYEPQDLPV TPRDWINAMD 420
  421 KMLGDYHFTC SVNEMALAHT KHGGDTYYYY FTHRASQQTW PEWMGVLHGY EINFIFGEPL 480
  481 NQKRFNYTDE ERELSNRFMR YWANFAKTGD PNKNEDGSFT QDVWPKYNSV SMEYMNMTVE 540
  541 SSYPSMKRIG HGPRRKECAF WKAYLPNLMA AVADVGDPYL VWKQQMDKWQ NEYITDWQYH 600
  601 FEQYKRYQTY RQSDSETCGG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..620] PSI-BLAST 137.0 Acetylcholinesterase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • acetylcholinesterase activity
    		•  6.01557374116734 bayes_pls_golite062009
  • juvenile hormone epoxide hydrolase activity
    		•  5.69212503305375 bayes_pls_golite062009
  • epoxide hydrolase activity
    		•  4.54228071084398 bayes_pls_golite062009
  • ether hydrolase activity
    		•  3.98161932704074 bayes_pls_golite062009
  • cholinesterase activity
    		•  3.53190978140684 bayes_pls_golite062009
  • hydrolase activity, acting on ether bonds
    		•  3.22022434415297 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  3.19190626066707 bayes_pls_golite062009
  • laminin-1 binding
    		•  2.61620056180634 bayes_pls_golite062009
  • choline binding
    		•  2.44944581139315 bayes_pls_golite062009
  • acetylcholine binding
    		•  2.15366394064412 bayes_pls_golite062009
  • carboxylesterase activity
    		•  2.10340684157921 bayes_pls_golite062009
  • lipase activity
    		•  1.95656432876646 bayes_pls_golite062009
  • hydrolase activity
    		•  1.89798820741335 bayes_pls_golite062009
  • palmitoyl-(protein) hydrolase activity
    		•  1.63586830236611 bayes_pls_golite062009
  • catalytic activity
    		•  1.39629727416851 bayes_pls_golite062009
  • sterol esterase activity
    		•  1.21262745914703 bayes_pls_golite062009
  • binding
    		•  0.978846093152455 bayes_pls_golite062009
  • peptidase activity
    		•  0.946698616106528 bayes_pls_golite062009
  • palmitoyl-CoA hydrolase activity
    		•  0.92549140936125 bayes_pls_golite062009
  • protein binding
    		•  0.890384359682543 bayes_pls_golite062009
  • receptor binding
    		•  0.845720597560984 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  0.786172015267385 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  0.715547007602635 bayes_pls_golite062009
  • serine hydrolase activity
    		•  0.527527404338 bayes_pls_golite062009
  • acylglycerol lipase activity
    		•  0.345658974420231 bayes_pls_golite062009
  • serine-type peptidase activity
    		•  0.33062249657108 bayes_pls_golite062009
  • heparin binding
    		•  0.219437684278316 bayes_pls_golite062009
  • phospholipase activity
    		•  0.1336535306364 bayes_pls_golite062009
  • triglyceride lipase activity
    		•  0.05324087110088 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle