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Protein Overview: CE06508

General Information:
Name(s) found: CE06508 [WormBase]
Description(s) found:
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  • WBGene00012015 6-phosphogluconate dehydrogenase, decarboxylating status:Confirmed UniProt:Q17761 protein_id:CAA94380.1 [WormBase]
  • gi|74962414|sp|Q17761.2|6PGD_CAEEL RecName: Full=6-phosphogluconate dehydrogenase, decarboxylating [NCBI NR]
  • pir||T19020 phosphogluconate dehydrogenase (decarboxylating) (EC 1.1.1.44) T25B9.9 - Caenorhabditis elegans [NCBI NR]
  • gi|3880188|emb|CAA94380.1| C. elegans protein T25B9.9, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|3874036|emb|CAA94326.1| C. elegans protein T25B9.9, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|17542558|ref|NP_501998.1| hypothetical protein T25B9.9 [Caenorhabditis elegans] [NCBI NR]
  • 6-phosphogluconate dehydrogenase, decarboxylating OS=Caenorhabditis elegans GN=T25B9.9 PE=3 SV=2 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE06508 WBGene00012015 6-phosphogluconate dehydrogenase status:Partially_confirmed TR:Q17761 protein_id:CAA94380.1 [wormpep150.fasta]
  • 06508 WBGene00012015 6-phosphogluconate dehydrogenase status:Partially_confirmed TR:Q17761 protein_id:CAA94380.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • 6-phosphogluconate dehydrogenase (53.2 kD) (4L541) [Caenorhabditis elegans]gi|3880188|emb|CAA94380.1| Hypothetical protein T25B9.9 [Caenorhabditis elegans]gi|3874036|emb|CAA94326.1| Hypothetical protein T25B9.9 [Caenorhabditis elegans]gi|7431258|pir||T [nrdb_11152004_Chlamydomonas]
  • 6-phosphogluconate dehydrogenase status:Partially_confirmed TR:Q17761 protein_id:CAA94380.1 [wormpep115.fasta.reversed]
  • CE06508 6-phosphogluconate dehydrogenase status:Partially_confirmed TR:Q17761 protein_id:CAA94380.1 [wormpep80.hongbin]
  • CE06508 WBGene00012015 6-phosphogluconate dehydrogenase status:Confirmed UniProt:Q17761 protein_id:CAA94380.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE06508 WBGene00012015 6-phosphogluconate dehydrogenase status:Confirmed UniProt:Q17761 protein_id:CAA94380.1| [wormORF-contam.fasta]
  • CE06508 WBGene00012015 6-phosphogluconate dehydrogenase status:Partially_confirmed SW:Q17761 protein_id:CAA94380.1 [wormpep160-contam.fasta]
  • Hypothetical protein T25B9.9 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • 6-phosphogluconate dehydrogenase, decarboxylating [nr-271106-contam.fasta]
  • T25B9.9 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE06508 WBGene00012015 6-phosphogluconate dehydrogenase status:Confirmed SW:Q17761 protein_id:CAA94380.1 [WormBase_C-elegans_wp180_08-19-2007_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE06508 WBGene00012015 status:Confirmed UniProt:Q17761 protein_id:CAA94380.1 6-phosphogluconate dehydrogenase, decarboxylating [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 484 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: pentose-phosphate shunt [IEALink to PubMed article]
    glyoxylate metabolic process [IEALink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    valine metabolic process [IEALink to PubMed article]
    Molecular Function: NADP or NADPH binding [IEALink to PubMed article]
    phosphogluconate dehydrogenase (decarboxylating) activity [IEALink to PubMed article]
    3-hydroxyisobutyrate dehydrogenase activity [IEALink to PubMed article]
    2-hydroxy-3-oxopropionate reductase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEADIAVIG LAVMGQNLIL NMNDHGFTVC AFNRTVKLVD DFLANEAKGT KIIGAHSIEE  60
   61 MCKKLKRPRR VMMLIKAGTP VDMMIDAIVP HLEEGDIIID GGNSEYTDSN RRSEQLAAKG 120
  121 IMFVGCGVSG GEEGARFGPS LMPGGNPKAW PHLKDIFQKI AAKSNGEPCC DWVGNAGSGH 180
  181 FVKMVHNGIE YGDMQLIAEA YHLLSKAVEL NHDQMAEVLD DWNKGELESF LIEITANILK 240
  241 YRDEQGEPIV PKIRDSAGQK GTGKWTCFAA LEYGLPVTLI GEAVFARCLS ALKDERVRAS 300
  301 KQLPRPQVSP DTVVQDKRVF IKQISKALYA SKIVSYAQGF MLLAEASKQF NWNLNFGAIA 360
  361 LMWRGGCIIR SRFLGDIEHA FQKNKQLSNL LLDDFFTKAI TEAQDSWRVV VCAAVRLGIP 420
  421 VPAFSSALAF YDGYTSEVVP ANLLQAQRDY FGAHTYELLA KPGTWVHTNW TGTGGRVTSN 480
  481 AYNA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..484] PSI-BLAST 131.0 CRYSTALLOGRAPHIC STUDY OF COENZYME, COENZYME ANALOGUE AND SUBSTRATE BINDING IN 6-PHOSPHOGLUCONATE DEHYDROGENASE: IMPLICATIONS FOR NADP SPECIFICITY AND THE ENZYME MECHANISM

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  2.27417613545298 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  2.0836009784049 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  1.29842732066898 bayes_pls_golite062009
  • retinol dehydrogenase activity
    		•  1.16811519855038 bayes_pls_golite062009
  • DNA binding
    		•  1.02274180655721 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  1.01627645289834 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.955628854752953 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.901776352952123 bayes_pls_golite062009
  • NAD or NADH binding
    		•  0.74536049628503 bayes_pls_golite062009
  • alcohol dehydrogenase (NAD) activity
    		•  0.65743456407889 bayes_pls_golite062009
  • binding
    		•  0.553666136934364 bayes_pls_golite062009
  • transcription factor activity
    		•  0.368443846770004 bayes_pls_golite062009
  • coenzyme binding
    		•  0.35922330382799 bayes_pls_golite062009
  • structural molecule activity
    		•  0.345975336806588 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.34220594024072 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.0385886223537015 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.86

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle