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Protein Overview: old-2

General Information:
Name(s) found: old-2 / CE03838 [WormBase]
Description(s) found:
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  • WBGene00003863 locus:old-2 status:Predicted UniProt:Q23677 protein_id:CAA90147.1 [WormBase]
  • pir||T28115 hypothetical protein ZK938.5 - Caenorhabditis elegans [NCBI NR]
  • gi|3881910|emb|CAA90147.1| Hypothetical protein ZK938.5 [Caenorhabditis elegans] [NCBI NR]
  • gi|17535347|ref|NP_496123.1| Overexpression Longevity Determinant family member (old-2) [Caenorhabditis elegans] [NCBI NR]
  • [wormpep67.fasta]
  • CE03838 WBGene00003863 locus:old-2 tyrosine-protein kinase (KIN15\/KIN16 subfamily) status:Predicted TR:Q23677 protein_id:CAA90147.1 [wormpep150.fasta]
  • 03838 WBGene00003863 locus:old-2 tyrosine-protein kinase (KIN15\/KIN16 subfamily) status:Predicted TR:Q23677 protein_id:CAA90147.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • overexpression Longevity Determinant OLD-2, growth factor receptor family member (old-2) [Caenorhabditis elegans]gi|3881910|emb|CAA90147.1| Hypothetical protein ZK938.5 [Caenorhabditis elegans]gi|7511428|pir||T28115 hypothetical protein ZK938.5 - Caenor [nrdb_11152004_Chlamydomonas]
  • locus:old-2 tyrosine-protein kinase (KIN15\/KIN16 subfamily) status:Predicted TR:Q23677 protein_id:CAA90147.1 [wormpep115.fasta.reversed]
  • CE03838 locus:old-2 tyrosine-protein kinase (KIN15\/KIN16 subfamily) status:Predicted TR:Q23677 protein_id:CAA90147.1 [wormpep80.hongbin]
  • CE03838 WBGene00003863 locus:old-2 tyrosine-protein kinase (KIN15\/KIN16 subfamily) status:Predicted UniProt:Q23677_CAEEL protein_id:CAA90147.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE03838 WBGene00003863 locus:old-2 tyrosine-protein kinase (KIN15\/KIN16 subfamily) status:Predicted UniProt:Q23677_CAEEL protein_id:CAA90147.1| [wormORF-contam.fasta]
  • Overexpression Longevity Determinant family member (old-2) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Hypothetical protein ZK938.5 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE03838 WBGene00003863 locus:old-2 tyrosine-protein kinase (KIN15\/KIN16 subfamily) status:Predicted UniProt:Q23677 protein_id:CAA90147.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • CE03838 WBGene00003863 locus:old-2 status:Predicted UniProt:Q23677 protein_id:CAA90147.1 [wormpep246-ecoli-contam.fasta]
  • Overexpression Longevity Determinant OS=Caenorhabditis elegans GN=old-2 PE=3 SV=1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 498 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    Biological Process: signal transduction [IEALink to PubMed article]
    determination of adult lifespan [IMPLink to PubMed article]
    protein amino acid phosphorylation [IEALink to PubMed article]
    Molecular Function: ATP binding [IEALink to PubMed article]
    protein tyrosine kinase activity [IEALink to PubMed article]
    non-membrane spanning protein tyrosine kinase activity [IEALink to PubMed article]
    transmembrane receptor protein tyrosine kinase activator activity [ISSLink to PubMed article]
    protein kinase activity [IEALink to PubMed article]
    protein serine/threonine kinase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTGSVIFFAL FSSYCFASCY ARNLTLGRNF EDSFKRVPRA SEKNELGDSN VQQIIFISLY  60
   61 SVFVALAIGI CCLIKAYKSK KRQLPANRSK GNEYLLEPTT ADQKKRYSNN IVPPEPTPYP 120
  121 ITSGEDDFGK TPSRLSNEEC PPELKLAPIN DRIKYLHYYA EVEINEEDLD ISKGRPLGSG 180
  181 EFGIIRKGFL RSKNSKNKET ESRLEVAVKS PLNEYNHIQQ ELIYDELKVM CAVGKHPNIL 240
  241 ALVGGITIGE KRMIISELVE NGDLLSFLRK NRRNFTIDQL AFEPEKPSLG LVDLVSFAFQ 300
  301 IAKGMEYLIH VPCVHRDLAL RNVLIKGNMV IRIADFGLAR RHKNKDYYKT QSVDTPLPIH 360
  361 WMAPESIDKL LFTQKSDVWS YGVCLYELFS LGKSPYKNVI KYDERDSYCK YVLAYLNEGK 420
  421 RLAQPAHADA EIYNVMKLCW DLDMNSRTTF LDCIEFFEKE LKTTSNEYFL DLTRKLRSET 480
  481 NNQLRLSNWL SDEKHCDS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..148] PSI-BLAST 19.221849 SH3-SH2 DOMAIN FRAGMENT OF HUMAN BCR-ABL TYROSINE KINASE
    2 View Details [149..498] PSI-BLAST 82.69897 No description for 2pvfA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein binding
    		•  3.13677730481089 bayes_pls_golite062009
  • binding
    		•  3.06905798270146 bayes_pls_golite062009
  • actin filament binding
    		•  2.59742039155224 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.21254869336424 bayes_pls_golite062009
  • signal transducer activity
    		•  1.80011194349017 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.80011194349017 bayes_pls_golite062009
  • actin binding
    		•  1.79651396322487 bayes_pls_golite062009
  • vinculin binding
    		•  1.63216315345235 bayes_pls_golite062009
  • transporter activity
    		•  0.896907103596953 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  0.80673395326897 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.713068405985864 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.500685400112742 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.275913005279959 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.272368655500689 bayes_pls_golite062009
  • receptor binding
    		•  0.0742205785215131 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.00318812576030902 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle