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View Structure Prediction Details

Protein: old-2
Organism: Caenorhabditis elegans
Length: 498 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for old-2.

Description E-value Query
Range
Subject
Range
gi|60811418 - gi|60811418|gb|AAX36172.1| fibroblast growth factor receptor 1 [synthetic construct]
384.0 [0..1] [491..321]

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Predicted Domain #1
Region A:
Residues: [1-148]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTGSVIFFAL FSSYCFASCY ARNLTLGRNF EDSFKRVPRA SEKNELGDSN VQQIIFISLY  60
   61 SVFVALAIGI CCLIKAYKSK KRQLPANRSK GNEYLLEPTT ADQKKRYSNN IVPPEPTPYP 120
  121 ITSGEDDFGK TPSRLSNEEC PPELKLAP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.221849
Match: 2ablA
Description: SH3-SH2 DOMAIN FRAGMENT OF HUMAN BCR-ABL TYROSINE KINASE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 3.13677730481089 bayes_pls_golite062009
binding 3.06905798270146 bayes_pls_golite062009
actin filament binding 2.59742039155224 bayes_pls_golite062009
cytoskeletal protein binding 2.21254869336424 bayes_pls_golite062009
signal transducer activity 1.80011194349017 bayes_pls_golite062009
molecular transducer activity 1.80011194349017 bayes_pls_golite062009
actin binding 1.79651396322487 bayes_pls_golite062009
vinculin binding 1.63216315345235 bayes_pls_golite062009
transporter activity 0.896907103596953 bayes_pls_golite062009
epidermal growth factor receptor binding 0.80673395326897 bayes_pls_golite062009
transmembrane transporter activity 0.713068405985864 bayes_pls_golite062009
substrate-specific transporter activity 0.500685400112742 bayes_pls_golite062009
insulin receptor binding 0.275913005279959 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.272368655500689 bayes_pls_golite062009
receptor binding 0.0742205785215131 bayes_pls_golite062009
ion transmembrane transporter activity 0.00318812576030902 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [149-498]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 INDRIKYLHY YAEVEINEED LDISKGRPLG SGEFGIIRKG FLRSKNSKNK ETESRLEVAV  60
   61 KSPLNEYNHI QQELIYDELK VMCAVGKHPN ILALVGGITI GEKRMIISEL VENGDLLSFL 120
  121 RKNRRNFTID QLAFEPEKPS LGLVDLVSFA FQIAKGMEYL IHVPCVHRDL ALRNVLIKGN 180
  181 MVIRIADFGL ARRHKNKDYY KTQSVDTPLP IHWMAPESID KLLFTQKSDV WSYGVCLYEL 240
  241 FSLGKSPYKN VIKYDERDSY CKYVLAYLNE GKRLAQPAHA DAEIYNVMKL CWDLDMNSRT 300
  301 TFLDCIEFFE KELKTTSNEY FLDLTRKLRS ETNNQLRLSN WLSDEKHCDS 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 82.69897
Match: 2pvfA
Description: No description for 2pvfA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle