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Protein Overview: brf-1

General Information:
Name(s) found: brf-1 / CE02738 [WormBase]
Description(s) found:
Found 19 descriptions.
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  • WBGene00000271 locus:brf-1 status:Partially_confirmed UniProt:Q20429 protein_id:CCD66264.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 759 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    Biological Process: nematode larval development [IMPLink to PubMed article]
    positive regulation of transcription [IEALink to PubMed article]
    gamete generation [IMPLink to PubMed article]
    regulation of transcription [IEALink to PubMed article]
    growth [IMPLink to PubMed article]
    Molecular Function: zinc ion binding [IEALink to PubMed article]
    transcription activator activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVRTCSNCGS SEIDEDAARG DATCTACGTV LEESIVVTEN QFQERAGGSG HTLVGQFVSS  60
   61 ERAAANNFNG MGSQESREMT YAKGRKVIDE LGSQLRINSH CMNTAFNFYK MCVSRNLTRG 120
  121 RNRSSVVAVC MYITCRLENT AHLLLDFSDV TQINVFDLGR NLNYLSRSLR INLPSTDPCL 180
  181 YIMRFACVLD FGDKQKEVVN LATRLVQRMK RDWMSTGRRP TGICGAALLI AARSLNFNRS 240
  241 INDIVRVVHI SEGVIRKRLD EFSQTPSGSL TIDEFSTVDL EHSEDPPAYR ESRRKAREDQ 300
  301 LRKEAEQAES MKEQLGEMEA HVEAALDKKR KEKFSKSPYA RMISENLGKE NDKMQTLTET 360
  361 VVESSGLEKG ADEMVRNEII NTVFNAAEED PCTSNSLEKY DKYRPSLESL GIKRTSEPEP 420
  421 EPVPHPIVNA DLEEDISDSE IDSYILTESE VAIKTDYWMK ANGEAMKEIE EKKRERELNG 480
  481 GVKKKKPRSN RKTDTTSTSV ASAVEKVIAE KKLSNKVNYE MLKDLETMAT GIKRDIREST 540
  541 PAPVTPISIK VDSSDVTPDT LSKSEKIARG KNIRSQASES TIQKLRSIFD LTEECSETSK 600
  601 NSSPKVNLKV ESASPSTSEV SSIEHKPFVP PARSRYAKVK PIIGAKKLAA LNEVKNVHTV 660
  661 PEPSAPAEPI VSEAPLQVKT SSSDPIVTST EVPSVAEPPA PIQNVEEAKP IVPVKSRYAK 720
  721 AKPNLKPIKQ KTAVDVVTVG EGESSEPSAK RTKAEHLES

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..62] MSA 1.090992 View MSA. No confident structure predictions are available.
    2 View Details [63..284] PSI-BLAST 64.0 Transcription factor IIB (TFIIB), core domain
    3 View Details [285..410] deduced N/A No confident structure predictions are available.
    4 View Details [411..511] FFAS03 2.58 TBP-binding domain of the transcription factor IIIb Brf1 subunit
    5 View Details [512..576] deduced N/A No confident structure predictions are available.
    6 View Details [577..759] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  5.81887489496763 bayes_pls_golite062009
  • binding
    		•  2.94365164362032 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.795846725429 bayes_pls_golite062009
  • DNA binding
    		•  1.6980508926231 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.63159454080484 bayes_pls_golite062009
  • cyclin-dependent protein kinase regulator activity
    		•  1.61958639505157 bayes_pls_golite062009
  • protein binding
    		•  1.49399866760259 bayes_pls_golite062009
  • protein kinase regulator activity
    		•  1.48643751045614 bayes_pls_golite062009
  • kinase regulator activity
    		•  1.34524931958191 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.09952334871968 bayes_pls_golite062009
  • transcription factor activity
    		•  1.0145450763465 bayes_pls_golite062009
  • transcription factor binding
    		•  0.749278791251235 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.502596616605714 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.138191616709499 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0696060248241566 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.83

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle