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Protein Overview: sem-5

General Information:
Name(s) found: sem-5 / CE01784 [WormBase]
Description(s) found:
Found 25 descriptions.
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  • WBGene00004774 locus:sem-5 Sex muscle abnormal protein 5 status:Confirmed UniProt:P29355 protein_id:CCD63850.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 228 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: muscle organ development [IMPLink to PubMed article]
    negative regulation of multicellular organism growth [IMPLink to PubMed article]
    hermaphrodite genitalia development [IMPLink to PubMed articleLink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    male genitalia development [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed articleLink to PubMed article]
    regulation of cell projection organization [IMPLink to PubMed article]
    gamete generation [IMPLink to PubMed article]
    cell migration [IMPLink to PubMed article]
    regulation of vulval development [IMPLink to PubMed article]
    Molecular Function: SH3/SH2 adaptor activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEAVAEHDFQ AGSPDELSFK RGNTLKVLNK DEDPHWYKAE LDGNEGFIPS NYIRMTECNW  60
   61 YLGKITRNDA EVLLKKPTVR DGHFLVRQCE SSPGEFSISV RFQDSVQHFK VLRDQNGKYY 120
  121 LWAVKFNSLN ELVAYHRTAS VSRTHTILLS DMNVETKFVQ ALFDFNPQES GELAFKRGDV 180
  181 ITLINKDDPN WWEGQLNNRR GIFPSNYVCP YNSNKSNSNV APGFNFGN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..228] PSI-BLAST 35.522879 Growth factor receptor-bound protein 2 (GRB2), N- and C-terminal domains; Growth factor receptor-bound protein 2 (GRB2)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.63972476345585 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.57554390739461 bayes_pls_golite062009
  • actin binding
    		•  2.17709619225063 bayes_pls_golite062009
  • protein binding
    		•  2.08632303609243 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.85015570449703 bayes_pls_golite062009
  • kinase activity
    		•  1.78069536883109 bayes_pls_golite062009
  • protein kinase activity
    		•  1.64363774024605 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.59739467025045 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.34867629228264 bayes_pls_golite062009
  • signal transducer activity
    		•  1.34867629228264 bayes_pls_golite062009
  • transferase activity
    		•  1.19152443245584 bayes_pls_golite062009
  • actin filament binding
    		•  1.03574214978228 bayes_pls_golite062009
  • phosphoinositide 3-kinase regulator activity
    		•  1.03150090191995 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  0.950445630788802 bayes_pls_golite062009
  • transporter activity
    		•  0.896907103596953 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  0.80673395326897 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.786324379459923 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.713068405985864 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.696368655705791 bayes_pls_golite062009
  • DNA binding
    		•  0.578730664467311 bayes_pls_golite062009
  • sevenless binding
    		•  0.418968910155118 bayes_pls_golite062009
  • receptor binding
    		•  0.351326788023913 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  0.30555304014394 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.245869952317152 bayes_pls_golite062009
  • structural molecule activity
    		•  0.236653863910566 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  0.206747304356052 bayes_pls_golite062009
  • kinase binding
    		•  0.131981353175621 bayes_pls_golite062009
  • transcription factor activity
    		•  0.0291114923524518 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.0273219613963591 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle