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Protein Overview: daf-7

General Information:
Name(s) found: daf-7 / CE01758 [WormBase]
Description(s) found:
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  • WBGene00000903 locus:daf-7 Dauer larva development regulatory growth factor daf-7 status:Confirmed UniProt:P92172 protein_id:CCD61866.1 [WormBase]
  • pir||T25451 transforming growth factor beta homolog - Caenorhabditis elegans [NCBI NR]
  • gi|3023636|sp|P92172.1|DAF7_CAEEL RecName: Full=Dauer larva development regulatory growth factor daf-7; AltName: Full=Abnormal dauer formation protein 7; Flags: Precursor [NCBI NR]
  • gi|17552832|ref|NP_497265.1| abnormal DAuer Formation family member (daf-7) [Caenorhabditis elegans] [NCBI NR]
  • gi|1750401|gb|AAB52554.1| Abnormal dauer formation protein 7 [Caenorhabditis elegans] [NCBI NR]
  • gi|1684869|gb|AAC47389.1| DAF-7 [Caenorhabditis elegans] [NCBI NR]
  • gi|1684867|gb|AAC47390.1| dauer larva development regulatory growth factor [Caenorhabditis elegans] [NCBI NR]
  • Dauer larva development regulatory growth factor daf-7 OS=Caenorhabditis elegans GN=daf-7 PE=1 SV=1 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE01758 WBGene00000903 locus:daf-7 transforming growth factor beta proteins status:Confirmed SW:P92172 protein_id:AAB52554.1 [wormpep150.fasta]
  • 01758 WBGene00000903 locus:daf-7 transforming growth factor beta proteins status:Confirmed SW:P92172 protein_id:AAB52554.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • abnormal DAuer Formation DAF-7, dauer larva development regulatory growth factor, a transforming growth factor beta superfamily member expressed in chemosensory neurons (39.5 kD) (daf-7) [Caenorhabditis elegans]gi|1750401|gb|AAB52554.1| Abnormal dauer fo [nrdb_11152004_Chlamydomonas]
  • locus:daf-7 transforming growth factor beta proteins status:Confirmed SW:P92172 protein_id:AAB52554.1 [wormpep115.fasta.reversed]
  • CE01758 locus:daf-7 transforming growth factor beta proteins status:Confirmed [wormpep80.hongbin]
  • CE01758 WBGene00000903 locus:daf-7 transforming growth factor beta proteins status:Confirmed UniProt:P92172 protein_id:AAB52554.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE01758 WBGene00000903 locus:daf-7 transforming growth factor beta proteins status:Confirmed UniProt:P92172 protein_id:AAB52554.1| [wormORF-contam.fasta]
  • Abnormal dauer formation protein 7 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • DAF-7 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Dauer larva development regulatory growth factor daf-7 precursor (Abnormal dauer formation protein 7) [nr-271106-contam.fasta]
  • dauer larva development regulatory growth factor [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • abnormal DAuer Formation family member (daf-7) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE01758 WBGene00000903 locus:daf-7 transforming growth factor beta proteins status:Confirmed UniProt:P92172 protein_id:CCD61866.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE01758 WBGene00000903 locus:daf-7 status:Confirmed UniProt:P92172 protein_id:CCD61866.1 Dauer larva development regulatory growth factor daf-7 [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 350 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: dauer larval development [IGILink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    Molecular Function: growth factor activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFMASSLPVF IFLLSLPHGL TFNCTNSGVC IEKMKQHRTE YLKNEILDQL NMKEAPKGLK  60
   61 PMDPEMKSVY LEMYRDLLEK DEQDMGVEMS FYTAKDPSYG ENPSQLVAKF DVTNDLERSD 120
  121 ILQATLTVSI EIPAKDSGML QDVQVQVYEK NEDGSMGEMV TSGIFATKGS ERISIQLPID 180
  181 TVKSWFTISP IQGIFVKAML DGRNVALHPQ QTTADVDNMR LQLSTRPKGS RKRRSHAKPV 240
  241 CNAEAQSKGC CLYDLEIEFE KIGWDWIVAP PRYNAYMCRG DCHYNAHHFN LAETGHSKIM 300
  301 RAAHKVSNPE IGYCCHPTEY DYIKLIYVNR DGRVSIANVN GMIAKKCGCS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..97] MSA 11.276997 View MSA. No confident structure predictions are available.
    2 View Details [98..225] MSA 8.376996 View MSA. No confident structure predictions are available.
    3 View Details [226..350] PSI-BLAST 37.30103 BONE MORPHOGENETIC PROTEIN-7

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • type II transforming growth factor beta receptor binding
    		•  8.13965462870591 bayes_pls_golite062009
  • vascular endothelial growth factor receptor 1 binding
    		•  7.85857332663967 bayes_pls_golite062009
  • platelet-derived growth factor receptor binding
    		•  6.4684557744685 bayes_pls_golite062009
  • vascular endothelial growth factor receptor binding
    		•  5.9885816311386 bayes_pls_golite062009
  • vascular endothelial growth factor receptor 2 binding
    		•  5.13799972612867 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  4.8369569327215 bayes_pls_golite062009
  • cytokine activity
    		•  4.8098396386842 bayes_pls_golite062009
  • growth factor activity
    		•  4.74498867224238 bayes_pls_golite062009
  • receptor binding
    		•  4.70889547404918 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
    		•  4.69128752159226 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  4.69128752159226 bayes_pls_golite062009
  • protein binding
    		•  3.41839891062651 bayes_pls_golite062009
  • fibronectin binding
    		•  3.36540670741416 bayes_pls_golite062009
  • binding
    		•  3.28090754728074 bayes_pls_golite062009
  • growth factor binding
    		•  3.23153419905493 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  3.12262133458315 bayes_pls_golite062009
  • cell surface binding
    		•  2.9725198156666 bayes_pls_golite062009
  • heparin binding
    		•  2.81661725670177 bayes_pls_golite062009
  • glial cell line-derived neurotrophic factor receptor binding
    		•  2.42595321135263 bayes_pls_golite062009
  • polysaccharide binding
    		•  2.42568523771453 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.31616116370197 bayes_pls_golite062009
  • hormone activity
    		•  2.10500409590202 bayes_pls_golite062009
  • platelet-derived growth factor binding
    		•  2.01091405432331 bayes_pls_golite062009
  • protein dimerization activity
    		•  1.82426827198541 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.69276038320301 bayes_pls_golite062009
  • transcription activator activity
    		•  1.63851701049695 bayes_pls_golite062009
  • collagen binding
    		•  1.56562537405529 bayes_pls_golite062009
  • protein kinase activity
    		•  1.41847295970293 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.40678896068326 bayes_pls_golite062009
  • signal transducer activity
    		•  1.40678896068326 bayes_pls_golite062009
  • protein homodimerization activity
    		•  1.377005150119 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  1.19300119957916 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.19169017348435 bayes_pls_golite062009
  • identical protein binding
    		•  1.18858126900765 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.1841101716474 bayes_pls_golite062009
  • kinase activity
    		•  1.15484804727089 bayes_pls_golite062009
  • cytokine binding
    		•  1.11655568277071 bayes_pls_golite062009
  • morphogen activity
    		•  0.91146826241391 bayes_pls_golite062009
  • pattern binding
    		•  0.90497366619649 bayes_pls_golite062009
  • neurotrophin receptor binding
    		•  0.81172494974121 bayes_pls_golite062009
  • vascular endothelial growth factor receptor 3 binding
    		•  0.772832351269279 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.675252100191059 bayes_pls_golite062009
  • neurotrophin TRK receptor binding
    		•  0.552075777293301 bayes_pls_golite062009
  • neurotrophin TRKB receptor binding
    		•  0.552075777293301 bayes_pls_golite062009
  • transforming growth factor beta binding
    		•  0.539891088283499 bayes_pls_golite062009
  • beta-amyloid binding
    		•  0.51409569546989 bayes_pls_golite062009
  • SMAD binding
    		•  0.195453215953383 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.1719107348851 bayes_pls_golite062009
  • follicle-stimulating hormone activity
    		•  0.126261994098681 bayes_pls_golite062009
  • catalytic activity
    		•  0.105223830172599 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.0235054088545197 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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