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Protein Overview: nex-1

General Information:
Name(s) found: nex-1 / CE01431 [WormBase]
Description(s) found:
Found 21 descriptions.
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  • WBGene00003588 locus:nex-1 Annexin status:Confirmed UniProt:G5EEA8 protein_id:CCD66672.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 322 amino acids

    Gene Ontology:
    Cellular Component: intracellular membrane-bounded organelle [IDA]
    plasma membrane [IDA]
    Biological Process: positive regulation of growth rate [IMP]
    engulfment of apoptotic cell [IMP]
    Molecular Function: calcium ion binding [IEALink to PubMed article]
    calcium-dependent phospholipid binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSPYATIVD AREFNAPMFA EKIDRALRAG EKDAVVNVIT SISNAQRQQL REPYKLKYGK  60
   61 DIIQALDKKF SGDLEKAIFA LMETPLDYDV KQLKAAMKGL GTDEAVLIEI LCSRTVDQLR 120
  121 AIRVTYEKEY GKALEADIAG DTSGEFRDLL VSLVTGSKDG SHDTNDAQAK DDAVRLFADG 180
  181 KAKLAKKDGT HFLHILATQN QYQLRKVFAY FQELAGGSIE KSIEKEFSGD LQKSYLTIVR 240
  241 AASDKQKFFA QQLHASMKGL GTRDNDLIRV IVTRSEVDLE LIKAEFQELY SKSLADTVKG 300
  301 DTSGAYRDAL LSIINGNHAT AH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..322] PSI-BLAST 120.0 ANNEXIN IV

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phospholipase A2 inhibitor activity
    		•  7.29552940171097 bayes_pls_golite062009
  • phospholipid binding
    		•  3.05141207134953 bayes_pls_golite062009
  • binding
    		•  2.96653224858825 bayes_pls_golite062009
  • lipase inhibitor activity
    		•  2.80498669672883 bayes_pls_golite062009
  • phospholipase inhibitor activity
    		•  2.80498669672883 bayes_pls_golite062009
  • actin binding
    		•  2.68781878266644 bayes_pls_golite062009
  • calcium-dependent phospholipid binding
    		•  2.57414697889588 bayes_pls_golite062009
  • protein binding
    		•  2.54206811927155 bayes_pls_golite062009
  • calcium-dependent protein binding
    		•  2.1295362527034 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.89826900114259 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.65977312589087 bayes_pls_golite062009
  • DNA binding
    		•  1.55427160364857 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.49257790869584 bayes_pls_golite062009
  • lipid binding
    		•  1.46457905774769 bayes_pls_golite062009
  • receptor activity
    		•  1.44506842958922 bayes_pls_golite062009
  • phosphatidylserine binding
    		•  1.21299532241397 bayes_pls_golite062009
  • receptor binding
    		•  1.20484213673545 bayes_pls_golite062009
  • signal transducer activity
    		•  1.20428429374783 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.20428429374783 bayes_pls_golite062009
  • acetylcholine receptor activity
    		•  0.948618205286169 bayes_pls_golite062009
  • acetylcholine binding
    		•  0.88218606905406 bayes_pls_golite062009
  • cell surface binding
    		•  0.732574496468741 bayes_pls_golite062009
  • enzyme inhibitor activity
    		•  0.60542945405181 bayes_pls_golite062009
  • actin filament binding
    		•  0.600441079301182 bayes_pls_golite062009
  • structural molecule activity
    		•  0.540239721421754 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle