YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: CE01115

General Information:
Name(s) found: CE01115 [WormBase]
Description(s) found:
Found 18 descriptions.
SHOW ALL
  • WBGene00014054 Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial status:Confirmed UniProt:Q23571 protein_id:CAA85465.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 448 amino acids

    Gene Ontology:
    Cellular Component: pyruvate dehydrogenase complex [IEALink to PubMed article]
    oxoglutarate dehydrogenase complex [IEALink to PubMed article]
    extracellular region [IEALink to PubMed article]
    Biological Process: embryonic development ending in birth or egg hatching [IMPLink to PubMed article]
    metabolic process [IEALink to PubMed article]
    glycolysis [IEALink to PubMed article]
    tricarboxylic acid cycle [IEALink to PubMed article]
    pyruvate metabolic process [IEALink to PubMed article]
    Molecular Function: dihydrolipoyllysine-residue succinyltransferase activity [IEALink to PubMed article]
    protein binding [IEALink to PubMed article]
    acyltransferase activity [IEALink to PubMed article]
    hormone activity [IEALink to PubMed article]
    dihydrolipoyllysine-residue acetyltransferase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMAARLLGTS SRIFKLNKHL HTSKVAFMPV VQFKLSDIGE GIAEVQVKEW YVKEGDTISQ  60
   61 FDKVCEVQSD KAAVTISCRY DGIVKKLYHE VDGMARVGQA LIDVEIEGNV EEPEQPKKEA 120
  121 ASSSPEAPKS SAPKAPESAH SEGKVLATPA VRRIAIENKI KLAEVRGTGK DGRVLKEDVL 180
  181 KFLGQVPADH TSGSTNIRTT HQAPQPSSKS YEPLKEDVAV PIRGYTRAMV KTMTEALKIP 240
  241 HFGYNDEINV DSLVKYRAEL KEFAKERHIK LSYMPFFIKA ASLALLEYPS LNSTTDEKME 300
  301 NVIHKASHNI CLAMDTPGGL VVPNIKNCEQ RSIFEIAQEL NRLLEAGKKQ QIKREDLIDG 360
  361 TFSLSNIGNI GGTYASPVVF PPQVAIGAIG KIEKLPRFDK HDNVIPVNIM KVSWCADHRV 420
  421 VDGATMARFS NRWKFYLEHP SAMLAQLK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run knl-1 No Comments Cheeseman, I.M., et al. (2004)
    View Run hcp-1 hcp1 IP from december2004 Cheeseman, I.M., et al. (2005)
    View Run hcp-2 hcp2 ip from december Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..98] PSI-BLAST 18.522879 Lipoyl domain of the mitochondrial branched-chain alpha-ketoacid dehydrogenase
    2 View Details [99..193] FFAS03 3.45 The crystal structure of dihydrolipoamide dehydrogenase and dihydrolipoamide dehydrogenase-binding protein (didomain) subcomplex of human pyruvate dehydrogenase complex.
    3 View Details [194..448] PSI-BLAST 80.69897 No description for 2ihwA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • dihydrolipoyllysine-residue acetyltransferase activity
    		•  7.74877411346968 bayes_pls_golite062009
  • S-acetyltransferase activity
    		•  7.59642806209362 bayes_pls_golite062009
  • dihydrolipoamide S-acyltransferase activity
    		•  7.45508609960612 bayes_pls_golite062009
  • pyruvate dehydrogenase activity
    		•  7.05950875585975 bayes_pls_golite062009
  • S-acyltransferase activity
    		•  5.24395351180663 bayes_pls_golite062009
  • acetyltransferase activity
    		•  3.55333192628786 bayes_pls_golite062009
  • acetyl-CoA carboxylase activity
    		•  3.31123635155865 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  2.83081843426182 bayes_pls_golite062009
  • CoA carboxylase activity
    		•  2.82233689048595 bayes_pls_golite062009
  • acyltransferase activity
    		•  2.79754636323803 bayes_pls_golite062009
  • ligase activity, forming carbon-carbon bonds
    		•  2.53708026587542 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  2.22092493760605 bayes_pls_golite062009
  • catalytic activity
    		•  1.39099902011318 bayes_pls_golite062009
  • binding
    		•  0.988780943163898 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  0.629490807878017 bayes_pls_golite062009
  • ligase activity
    		•  0.56894584941056 bayes_pls_golite062009
  • aminomethyltransferase activity
    		•  0.377624262164477 bayes_pls_golite062009
  • protein binding
    		•  0.273657523907432 bayes_pls_golite062009
  • glycine dehydrogenase (decarboxylating) activity
    		•  0.0222922933292004 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
    		•  0.0222922933292004 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle