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View Structure Prediction Details

Protein: CE01115
Organism: Caenorhabditis elegans
Length: 448 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CE01115.

Description E-value Query
Range
Subject
Range
gi|15614768, gi|... - gi|15614768|ref|NP_243071.1| dihydrolipoamide acetyltransferase [Bacillus halodurans C-125], gi|1017...
gi|25286430 - pir||E83925 dihydrolipoamide succinyltransferase BH2205 [imported] - Bacillus halodurans (strain C-1...
436.0 [0..30] [446..1]

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Predicted Domain #1
Region A:
Residues: [1-98]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMAARLLGTS SRIFKLNKHL HTSKVAFMPV VQFKLSDIGE GIAEVQVKEW YVKEGDTISQ  60
   61 FDKVCEVQSD KAAVTISCRY DGIVKKLYHE VDGMARVG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.522879
Match: 1k8mA
Description: Lipoyl domain of the mitochondrial branched-chain alpha-ketoacid dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
dihydrolipoyllysine-residue acetyltransferase activity 7.74877411346968 bayes_pls_golite062009
S-acetyltransferase activity 7.59642806209362 bayes_pls_golite062009
dihydrolipoamide S-acyltransferase activity 7.45508609960612 bayes_pls_golite062009
pyruvate dehydrogenase activity 7.05950875585975 bayes_pls_golite062009
S-acyltransferase activity 5.24395351180663 bayes_pls_golite062009
acetyltransferase activity 3.55333192628786 bayes_pls_golite062009
acetyl-CoA carboxylase activity 3.31123635155865 bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups 2.83081843426182 bayes_pls_golite062009
CoA carboxylase activity 2.82233689048595 bayes_pls_golite062009
acyltransferase activity 2.79754636323803 bayes_pls_golite062009
ligase activity, forming carbon-carbon bonds 2.53708026587542 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors 2.22092493760605 bayes_pls_golite062009
catalytic activity 1.39099902011318 bayes_pls_golite062009
binding 0.988780943163898 bayes_pls_golite062009
transferase activity, transferring acyl groups 0.629490807878017 bayes_pls_golite062009
ligase activity 0.56894584941056 bayes_pls_golite062009
aminomethyltransferase activity 0.377624262164477 bayes_pls_golite062009
protein binding 0.273657523907432 bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity 0.0222922933292004 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor 0.0222922933292004 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [99-193]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QALIDVEIEG NVEEPEQPKK EAASSSPEAP KSSAPKAPES AHSEGKVLAT PAVRRIAIEN  60
   61 KIKLAEVRGT GKDGRVLKED VLKFLGQVPA DHTSG

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.45
Match: 1zy8K
Description: The crystal structure of dihydrolipoamide dehydrogenase and dihydrolipoamide dehydrogenase-binding protein (didomain) subcomplex of human pyruvate dehydrogenase complex.
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [194-448]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STNIRTTHQA PQPSSKSYEP LKEDVAVPIR GYTRAMVKTM TEALKIPHFG YNDEINVDSL  60
   61 VKYRAELKEF AKERHIKLSY MPFFIKAASL ALLEYPSLNS TTDEKMENVI HKASHNICLA 120
  121 MDTPGGLVVP NIKNCEQRSI FEIAQELNRL LEAGKKQQIK REDLIDGTFS LSNIGNIGGT 180
  181 YASPVVFPPQ VAIGAIGKIE KLPRFDKHDN VIPVNIMKVS WCADHRVVDG ATMARFSNRW 240
  241 KFYLEHPSAM LAQLK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 80.69897
Match: 2ihwA
Description: No description for 2ihwA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle