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Protein Overview: sfc4

General Information:
Name(s) found: sfc4 / SPCC16C4.14c [Sanger Pombe]
Description(s) found:
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  • pir||T41104 probable transcription factor subunit, TPR domai ns - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|74676083|sp|O74458.1|SFC4_SCHPO RecName: Full=Transcription factor tau subunit sfc4; AltName: Full=TFIIIC subunit sfc4; AltName: Full=Transcription factor C subunit 4 [NCBI NR]
  • gi|3560268|emb|CAA20753.1| transcription factor TFIIIC complex subunit Sfc4 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19075424|ref|NP_587924.1| transcription factor TFIIIC complex subunit Sfc4 [Schizosaccharomyces pombe] [NCBI NR]
  • transcription factor TFIIIC complex subunit Sfc4 [Sanger Pombe]
  • Transcription factor tau subunit sfc4 OS=Schizosaccharomyces pombe GN=sfc4 PE=1 SV=1 [Swiss-Prot]
  • RNA POLYMERASE III TRANSCRIPTION FACTOR TFIIIC SUBUNIT; BRF-ASSOCIATED BINDING SUBUNIT; CONTAINS TPR DOMAINS: O74458; [pompepVF.fasta]
  • RNA POLYMERASE III TRANSCRIPTION FACTOR (TF)IIIC SUBUNIT; BRF-ASSOCIATED BINDING SUBUNIT; CONTAINS TPR DOMAINS: O74458; [pompepV13]
  • RNA polymerase III transcription factor (TF)IIIC subunit [pompep4896]
  • |sfc4||RNA polymerase III Transcription factor TFIIIC subunit [pompepnew.fasta]
  • Sfc4 protein (Spcc16c4.14c protein) [4896.FASTAC]
  • |sfc4||transcription factor activity|Schizosaccharomyces pombe|chr 3|||Manual [pombe041504.fasta]
  • RNA polymerase III Transcriptioon factor (TF)IIIC subunit; Brf-associated binding subunit; contains TPR domains [Schizosaccharomyces pombe]gi|3560268|emb|CAA20753.1| SPCC16C4.14c [Schizosaccharomyces pombe]gi|7493054|pir||T41104 probable transcription f [nrdb_11152004_Chlamydomonas]
  • |sfc4||transcription factor TFIIIC complex|Schizosaccharomyces pombe|chr 3|||Manual [pompep2242005.fasta]
  • (O74458) RNA polymerase III transcription factor (TF)IIIC subunit [pompep4896_normal_reversed]
  • |sfc4||transcription factor TFIIIC complex subunit Sfc4|Schizosaccharomyces pombe|chr 3|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • SPCC16C4.14c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPCC16C4.14c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • Transcription factor tau subunit sfc4 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=sfc4 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 1006 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    transcription factor TFIIIC complex [IDALink to PubMed article]
    Biological Process: transcription initiation from RNA polymerase III promoter [IDALink to PubMed article]
    regulation of transcription [ICLink to PubMed article]
    Molecular Function: chromatin insulator sequence binding [IDALink to PubMed article]
    RNA polymerase III transcription factor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIQNGGNSYV DSNMNETQND TTDNFDAEMQ DLNGYISEIV DEARNVSEVD AKFLGDTSAL  60
   61 QAEGLWSDEE SDYEGSDDES NFSKTASRTE DDIANEEWEE NLKAVAGFRK VRKGHKGRGR 120
  121 VSRADMLPSV EVQQMLSLAN HLFAQEGNFD EAQKLAEEIV RIDNNVIAAW KMLGECHRQR 180
  181 GNGRVNIEKC LIAWMAAAHL KPKDHELWFT CAKLSESLEF WDQADYCYNR AVSAKPPNKS 240
  241 ELKKYIWNRS VLNKEHGSLK KAAEGFKFLL QSSPYNASIL KNLAEIYIKI HAPREILKQF 300
  301 EIAWKYFYQY PAPPIGNDIF DLPTLNLYAE LLLLDHQWSN LIRLINRGVR WFRGRKSESF 360
  361 WDEFDDDREW DVDERRREFP NASEEHTNKE AYLLPHLFRT KLGIARLKTG ELPEAELHFS 420
  421 VIKNLPPDYA WGMLYDIAKA YMDIERLDLA LEYFVLICNH EPAQNIGLWY NMGVCYLELK 480
  481 EYEHAQQCME AILIVDNSNT NALIKLAEIN ELQDNRDAAL EIVTNIFEQR RNINELEREQ 540
  541 SQNEDHEKNV GSQLFVGNQK VPQDKWEKRA RISRSKEEAR QFTIWKTEET QRRFHKLDIL 600
  601 RQSLKKEENV SESLNEWLAI ASELIDEFVS IKAFFPSEKK ARARAGLLTR RTRYASLNDQ 660
  661 LTSMINRLND SLTRTKYGDL DLDTILRTGY FRNVSIDAWY QLFVEFSLRL TKVGSVQQAY 720
  721 DVLTTAMGAI LFDQDTIKRQ NLRWCMLACS MYARDPQGAL TPLRWVFTTF QFRQDTYRLF 780
  781 SAVLSQGYEC SRAFVDSANQ KFLLRLIKLM DQLMSNSLVS GAATLVKNDD GLATVPTSYD 840
  841 PVLVLLYGHI MARNRSWIPA INYYSRAFAI NPDCPITNLS LGLAYLHRAM QRLSDNRHYQ 900
  901 ILQGFTFLYR YYDLRVNEGL GEKQEALYNL GKAYHFIGLE HYAVKYYEAV LGLSPMSQGD 960
  961 KMTSSESTVS TTYDFGFEAA YNLRLIYICS GNIKLAFQIS SKYLIF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..87] deduced N/A No confident structure predictions are available.
    2 View Details [88..479] PSI-BLAST 45.69897 The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.
    3 View Details [480..675] PSI-BLAST 4.0 Crystal Structure of the Hypothetical protein VPA1032 from Vibrio parahaemolyticus, Northeast Structural Genomics Target VpR44
    4 View Details [676..1006] PSI-BLAST 22.045757 No description for 2j9qA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  3.24290984515946 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.36571535004008 bayes_pls_golite062009
  • protein binding
    		•  1.83529176977066 bayes_pls_golite062009
  • DNA binding
    		•  1.71381351716702 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.61516860680687 bayes_pls_golite062009
  • transcription factor activity
    		•  1.01338808398786 bayes_pls_golite062009
  • transcription factor binding
    		•  0.518146612491969 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.30464889749774 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.116119418380222 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0593768116971065 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle