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Protein Overview: dus2

General Information:
Name(s) found: dus2 / SPBC1709.06 [Sanger Pombe]
Description(s) found:
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  • pir||T39634 conserved hypothetical protein SPBC1709.06-Uncharacterized protein family UPF0034 member - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|74582543|sp|O74731.1|DUS2_SCHPO RecName: Full=tRNA-dihydrouridine synthase 2 [NCBI NR]
  • gi|3738144|emb|CAA21245.1| tRNA dihydrouridine synthase Dus2 (predicted) [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19112231|ref|NP_595439.1| tRNA dihydrouridine synthase Dus2 (predicted) [Schizosaccharomyces pombe] [NCBI NR]
  • tRNA dihydrouridine synthase Dus2 [Sanger Pombe]
  • tRNA-dihydrouridine synthase 2 OS=Schizosaccharomyces pombe GN=dus2 PE=2 SV=1 [Swiss-Prot]
  • CONSERVED PROTEIN; UPF0034 FAMILY; SIMILAR TO S. CEREVISIAE SMM1: O74731; [pompepVF.fasta]
  • CONSERVED HYPOTHETICAL PROTEIN; UPF0034 FAMILY: O74731; [pompepV13]
  • Conserved hypothetical protein, UPF0034 family [pompep4896]
  • |||putative dihydrouridine synthase [pompepnew.fasta]
  • SPBC1709.06 protein [4896.FASTAC]
  • |||dihydrouridine synthase (predicted)|Schizosaccharomyces pombe|chr 2|||Manual [pombe041504.fasta]
  • conserved hypothetical protein; UPF0034 family [Schizosaccharomyces pombe]gi|3738144|emb|CAA21245.1| SPBC1709.06 [Schizosaccharomyces pombe]gi|7490315|pir||T39634 conserved hypothetical protein SPBC1709.06-Uncharacterized protein family UPF0034 member - [nrdb_11152004_Chlamydomonas]
  • |||dihydrouridine synthase |Schizosaccharomyces pombe|chr 2|||Manual [pompep2242005.fasta]
  • (O74731) Conserved hypothetical protein, UPF0034 family [pompep4896_normal_reversed]
  • |dus2||tRNA dihydrouridine synthase Dus2 |Schizosaccharomyces pombe|chr 2|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • SPBC1709.06 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • dihydrouridine synthase [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • tRNA-dihydrouridine(20) synthase [NAD(P)+] OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=dus2 PE=3 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 479 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][ISSLink to PubMed article]
    cytoplasm [ISSLink to PubMed article]
    Biological Process: tRNA modification [ISSLink to PubMed article]
    Molecular Function: tRNA dihydrouridine synthase activity [ISSLink to PubMed article]
    FAD binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGLLNYSNKV CLAPMVRIGE LPMRLLALRY GANLVWGPEI VDKALLSGTP VERVVNDRIN  60
   61 CIDFVKPPSN KVLFRVHPLE ANRLIFQLGS ASPELAVEAA KLVANDVAGI DLNCGCPKHF 120
  121 SVHAGMGAGL LKNQDRLVSI LDALVNEIGK PYKISISCKI RLLETKEDTL KLVERICDTG 180
  181 VRAITVHCRT TPMRNTEPAD RSYLSEIVGV CRNKDVSILV NGDVLSYNDG LDVIEKYGVD 240
  241 GVLIARAAER NVSCFRIEGP LSSFKVAEEF LKMALEVDNN FGNTKYCLNQ IMQGSFRKNV 300
  301 RQLAQTAKTY EDLKKAFEIE YKHSDASSVC PTLEKEKSLV ISFVDLPSFL ESLLASNILK 360
  361 QLSRLHFTKI FAVSEEEDIC KQLDDIHEKF LCHGIALSLI SADNLASAIA SAHLVICMEK 420
  421 DESIMNEAVC DQKITIRLPI NSNTNEAVVE CENKSMQSKH ALDIIQERIK DLEEKAQVV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..345] PSI-BLAST 49.0 Crystal structure of a putative flavin oxidoreductase with flavin
    2 View Details [346..479] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • catalytic activity
    		•  1.94749091175302 bayes_pls_golite062009
  • tRNA dihydrouridine synthase activity
    		•  1.94490879164338 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.03692680161964 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors
    		•  0.876786102965635 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.80115790656025 bayes_pls_golite062009
  • binding
    		•  0.68572942532795 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle