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Protein Overview: uba5

General Information:
Name(s) found: uba5 / SPAC323.06c [Sanger Pombe]
Description(s) found:
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  • pir||T38643 conserved hypothetical protein SPAC323.06c - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|74625922|sp|Q9UT93.1|ULA1_SCHPO RecName: Full=NEDD8-activating enzyme E1 regulatory subunit; AltName: Full=Ubiquitin-like activation protein 1; AltName: Full=Ubiquitin-activating enzyme E1-like 1 [NCBI NR]
  • gi|6066734|emb|CAB53409.2| NEDD8 activating enzyme (predicted) [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19115288|ref|NP_594376.1| NEDD8 activating enzyme (predicted) [Schizosaccharomyces pombe 972h-] [NCBI NR]
  • NEDD8 activating enzyme [Sanger Pombe]
  • NEDD8-activating enzyme E1 regulatory subunit OS=Schizosaccharomyces pombe GN=ula1 PE=2 SV=1 [Swiss-Prot]
  • UBIQUITIN ACTIVATING ENZYME: Q9UT93; [pompepVF.fasta]
  • Ubiquitin activating enzyme [pompep4896]
  • |uba5||ubiquitin activating enzyme [pompepnew.fasta]
  • Uba5 protein (Spac323.06c protein) [4896.FASTAC]
  • |uba5||ubiquitin activating enzyme|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • ubiquitin activating enzyme [Schizosaccharomyces pombe]gi|6066734|emb|CAB53409.2| SPAC323.06c [Schizosaccharomyces pombe]gi|7490289|pir||T38643 conserved hypothetical protein SPAC323.06c - fission yeast (Schizosaccharomyces pombe) [nrdb_11152004_Chlamydomonas]
  • (Q9UT93) Ubiquitin activating enzyme [pompep4896_normal_reversed]
  • |uba5||NEDD8 activating enzyme |Schizosaccharomyces pombe|chr 1|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • SPAC323.06c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPAC323.06c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • NEDD8-activating enzyme E1 regulatory subunit (Ubiquitin-like activation protein 1) (Ubiquitin-activating enzyme E1-like 1) [nr-271106-contam.fasta]
    • Organism: Schizosaccharomyces pombe
    Length: 500 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: protein neddylation [ISSLink to PubMed article]
    Molecular Function: ATP binding [IEA]
    NEDD8 activating enzyme activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGTSAKMQKY DRQVRLWKAE GQNAIEKSHV CLLYANTVGC EALKNLILPG IGSFAVVDDT  60
   61 SVDFSMDGMN FFIQYDQEGK SRARCTASLL QQLNPNVEME YLEMSPEALI DKNIEYFSKF 120
  121 SVVLSSNLKE KPLFRLEEYL RSHKIPLLHF NSVGFAGILR ISTHEYTTTQ SQPELPQDLR 180
  181 LKNPWPELIN YVKSMDLDNM DSSSLSEIPY IVLIIHVLLK VSPAHAQNSQ EADDCAMFRK 240
  241 IMEEYKGKCD SENIEEASSN SWKAFKEYKL PSNVYEVLHD TRCVKIQEDS ESFWIMAHCL 300
  301 KMFYDETEFL PLSGLLPDMN CSTQQYVKLQ VIYKEKSEND ILKFKKYVQQ TLKRLNRSVE 360
  361 EITDLEIKHF SRNCLNIKVM DFKTMKEEYQ PTSNSAFRIY DTILEKHGKN YKEAFSDTTK 420
  421 TISVAQSFLS QIGLEKFFDV VYTAIQELER ADGHELHSIS SFIGGIVAQE TIKLLAQQYL 480
  481 PLNNTFVFDG VHSRTETFKL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..500] PSI-BLAST 116.0 Structure of APPBP1-UBA3-Ubc12N26: a unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • small protein activating enzyme activity
    		•  5.883593664369 bayes_pls_golite062009
  • NEDD8 activating enzyme activity
    		•  4.6334061288737 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  1.84216910649062 bayes_pls_golite062009
  • binding
    		•  1.66028321721112 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  1.63522698057369 bayes_pls_golite062009
  • protein binding
    		•  1.40907622346701 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.31244773198273 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  1.27535252106053 bayes_pls_golite062009
  • catalytic activity
    		•  1.22201444897049 bayes_pls_golite062009
  • NEDD8 ligase activity
    		•  1.11310449351601 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.995905648772847 bayes_pls_golite062009
  • transferase activity
    		•  0.680338489823338 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.302798969355962 bayes_pls_golite062009
  • URM1 activating enzyme activity
    		•  0.207228630005671 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle