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Protein Overview: erg8

General Information:
Name(s) found: erg8 / SPAC343.01c [Sanger Pombe]
Description(s) found:
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  • pir||T38650 probable phosphomevalonate kinase - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|74638892|sp|Q9UT88.1|ERG8_SCHPO RecName: Full=Probable phosphomevalonate kinase [NCBI NR]
  • gi|5706502|emb|CAB52264.1| phosphomevalonate kinase (predicted) [Schizosaccharomyces pombe] [NCBI NR]
  • ref|NP_593421.1| putative phosphomevalonate kinase [Schizosaccharomyces pombe] [NCBI NR]
  • gi|162312410|ref|NP_593421.3| phosphomevalonate kinase (predicted) [Schizosaccharomyces pombe 972h-] [NCBI NR]
  • phosphomevalonate kinase [Sanger Pombe]
  • Probable phosphomevalonate kinase OS=Schizosaccharomyces pombe GN=erg8 PE=2 SV=1 [Swiss-Prot]
  • PUTATIVE PHOSPHOMEVALONATE KINASE: Q9UT88; [pompepVF.fasta]
  • Putative phosphomevalonate kinase [pompep4896]
  • |||putative phosphomevalonate kinase [pompepnew.fasta]
  • SPAC343.01c protein [4896.FASTAC]
  • |||phosphomevalonate kinase activity (predicted)|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • putative phosphomevalonate kinase [Schizosaccharomyces pombe]gi|5706502|emb|CAB52264.1| SPAC343.01c [Schizosaccharomyces pombe]gi|7492820|pir||T38650 probable phosphomevalonate kinase - fission yeast (Schizosaccharomyces pombe) [nrdb_11152004_Chlamydomonas]
  • |erg8||phosphomevalonate kinase |Schizosaccharomyces pombe|chr 1|||Manual [pompep2242005.fasta]
  • (Q9UT88) Putative phosphomevalonate kinase [pompep4896_normal_reversed]
  • SPAC343.01c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • Probable phosphomevalonate kinase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=erg8 PE=3 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 426 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    cytosol [IDALink to PubMed article][ISSLink to PubMed article]
    Biological Process: ergosterol biosynthetic process [ISSLink to PubMed article]
    isoprenoid biosynthetic process [IEA]
    phosphorylation [IEA]
    Molecular Function: ATP binding [IEA]
    phosphomevalonate kinase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVTCSAPGK VLIAGGYIVL DPQYSGLVIG LTAKGYASTT TLDDKCGTVR VKSPQFINAE  60
   61 WLYNIDWTVS PIRVHQIYEN CELEKNPNPF VQLALFYVIN YFFSTGRQPL CWQDLQVTLQ 120
  121 VDNAYYHQPQ LKPDQTSYPK FNFLNCTLGQ VHKTGLGSSA AMITSLIGSL FLSLRRLTDD 180
  181 TGDKSLKIDD STKVIVHNLA QIAHCSAQGK VGSGFDVGAA TWGSCIYRRF DPKLIEQLLV 240
  241 PYDEQIKNIN FSTELRKIVS KKWSDVVPFQ LPATYCLLMG DVAGGSSTPG MVKKVQQWQK 300
  301 ENPEESKNCF DDLYSRVLSI KNCFLSSESL DSELQSQFRS IRRILQRITV EAKVDIEPLK 360
  361 QTNILDNIEQ LPGVIGVGVP GAGGFDAQFC LAINHTEIIE NVIKTWKDDG VVPMDVSPAF 420
  421 DGLAVE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..426] PSI-BLAST 65.30103 crystal structure of human galactokinase complexed with MgAMPPNP and galactose

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • carbohydrate kinase activity
    		•  1.15507603461537 bayes_pls_golite062009
  • catalytic activity
    		•  0.878454819018611 bayes_pls_golite062009
  • diphosphomevalonate decarboxylase activity
    		•  0.58217666811758 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.369771518688522 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.325699575011026 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.212099606954236 bayes_pls_golite062009
  • structural molecule activity
    		•  2.19428886088058E-4 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.84

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle