YRC Public Data Repository - Protein Structure Prediction

Protein:	erg8
Organism:	Schizosaccharomyces pombe
Length:	426 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for erg8.

Description	E-value	Query Range	Subject Range
gi\|63054542 - gi\|63054542\|ref\|NP_593421.2\| hypothetical protein SPAC343.01c [Schizosaccharomyces pombe 972h-]	287.0	[0..1]	[414..1]
GAL1_EXIS2 - Galactokinase OS=Exiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15) GN=galK PE=3 SV=1	264.0	[0..4]	[424..21]
GAL1_LACPL - Galactokinase OS=Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) GN=galK PE=3 SV=... gi\|254046867, gi... - gi\|254557940\|ref\|YP_003064357.1\| galactokinase [Lactobacillus plantarum JDM1], gi\|254046867\|gb\|ACT63... gi\|227897230, gi... - gi\|227897230\|ref\|ZP_04015035.1\| galactokinase [Lactobacillus plantarum subsp. plantarum ATCC 14917],... GAL1_LACPL - Galactokinase OS=Lactobacillus plantarum GN=galK PE=3 SV=1	255.0	[0..4]	[422..21]
gi\|59803287 - gi\|59803287\|gb\|AAX07752.1\| galactokinase [Klebsiella pneumoniae] gi\|238893786, gi... - gi\|238893786\|ref\|YP_002918520.1\| galactokinase [Klebsiella pneumoniae NTUH-K2044], gi\|238546102\|dbj\|...	252.0	[0..4]	[423..22]
gi\|116492014, gi... - gi\|116492014\|ref\|YP_803749.1\| galactokinase [Pediococcus pentosaceus ATCC 25745], gi\|116102164\|gb\|AB...	252.0	[0..4]	[422..21]
GAL1_BACSU - Galactokinase OS=Bacillus subtilis (strain 168) GN=galK PE=3 SV=1 gi\|221316111 - gi\|221316111\|ref\|ZP_03597916.1\| galactokinase [Bacillus subtilis subsp. subtilis str. NCIB 3610] GAL1_BACSU - Galactokinase OS=Bacillus subtilis GN=galK PE=3 SV=1 gi\|221321023 - gi\|221321023\|ref\|ZP_03602317.1\| galactokinase [Bacillus subtilis subsp. subtilis str. JH642] gi\|221325307 - gi\|221325307\|ref\|ZP_03606601.1\| galactokinase [Bacillus subtilis subsp. subtilis str. SMY]	251.0	[0..4]	[424..21]
gi\|116216280, gi... - gi\|75823085\|ref\|ZP_00752617.1\| COG0153: Galactokinase [Vibrio cholerae RC385], gi\|116216280\|ref\|ZP_0...	251.0	[0..5]	[423..24]
gi\|76645595 - gi\|76645595\|ref\|XP_887859.1\| PREDICTED: similar to Galactokinase (Galactose kinase) isoform 3 [Bos t...	251.0	[0..2]	[425..29]
gi\|167469851 - gi\|167469851\|ref\|ZP_02334555.1\| galactokinase [Yersinia pestis FV-1] GAL1_YERPE - Galactokinase OS=Yersinia pestis GN=galK PE=3 SV=1 gi\|167056802, gi... - gi\|167423953\|ref\|ZP_02315706.1\| galactokinase [Yersinia pestis biovar Mediaevalis str. K1973002], gi... gi\|21959960, gi\|... - gi\|22126922\|ref\|NP_670345.1\| galactokinase [Yersinia pestis KIM], gi\|21959960\|gb\|AAM86596.1\|AE013905... GAL1_YERPY - Galactokinase OS=Yersinia pseudotuberculosis serotype O:3 (strain YPIII) GN=galK PE=3 SV=1 gi\|15979201, gi\|... - gi\|218928302\|ref\|YP_002346177.1\| galactokinase [Yersinia pestis CO92], gi\|16121434\|ref\|NP_404747.1\| ... gi\|45435715, gi\|... - gi\|45440857\|ref\|NP_992396.1\| galactokinase [Yersinia pestis biovar Microtus str. 91001], gi\|45435715... gi\|149366866, gi... - gi\|149366866\|ref\|ZP_01888900.1\| galactokinase [Yersinia pestis CA88-4125], gi\|149291240\|gb\|EDM41315.... GAL1_YERPP - Galactokinase OS=Yersinia pestis (strain Pestoides F) GN=galK PE=3 SV=1 gi\|165913663, gi... - gi\|89105178\|ref\|ZP_01177702.1\| COG0153: Galactokinase [Yersinia pestis biovar Orientalis str. IP275]... GAL1_YERPA - Galactokinase OS=Yersinia pestis bv. Antiqua (strain Antiqua) GN=galK PE=3 SV=1 gi\|165924472, gi... - gi\|165924472\|ref\|ZP_02220304.1\| galactokinase [Yersinia pestis biovar Orientalis str. F1991016], gi\|... GAL1_YERPN - Galactokinase OS=Yersinia pestis bv. Antiqua (strain Nepal516) GN=galK PE=3 SV=1 gi\|166211591, gi... - gi\|166211591\|ref\|ZP_02237626.1\| galactokinase [Yersinia pestis biovar Antiqua str. B42003004], gi\|16... gi\|165989569, gi... - gi\|166011621\|ref\|ZP_02232519.1\| galactokinase [Yersinia pestis biovar Antiqua str. E1979001], gi\|165... gi\|166962179, gi... - gi\|167419438\|ref\|ZP_02311191.1\| galactokinase [Yersinia pestis biovar Orientalis str. MG05-1020], gi... gi\|167050115, gi... - gi\|167400166\|ref\|ZP_02305679.1\| galactokinase [Yersinia pestis biovar Antiqua str. UG05-0454], gi\|16... GAL1_YERPG - Galactokinase OS=Yersinia pestis bv. Antiqua (strain Angola) GN=galK PE=3 SV=1 GAL1_YERP3 - Galactokinase OS=Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) GN=galK PE=3 SV=1 gi\|229841075, gi... - gi\|229841075\|ref\|ZP_04461234.1\| galactokinase [Yersinia pestis biovar Orientalis str. PEXU2], gi\|229... gi\|229843179, gi... - gi\|229843179\|ref\|ZP_04463325.1\| galactokinase [Yersinia pestis biovar Orientalis str. India 195], gi... gi\|229703898, gi... - gi\|229894013\|ref\|ZP_04509199.1\| galactokinase [Yersinia pestis Pestoides A], gi\|229703898\|gb\|EEO9091...	250.0	[0..3]	[423..21]
gi\|229607867, gi... - gi\|229607867\|ref\|YP_002878515.1\| galactokinase [Vibrio cholerae MJ-1236], gi\|229370522\|gb\|ACQ60945.1... gi\|229508460, gi... - gi\|229508460\|ref\|ZP_04397963.1\| galactokinase [Vibrio cholerae BX 330286], gi\|229354414\|gb\|EEO19337.... gi\|229518608, gi... - gi\|229518608\|ref\|ZP_04408051.1\| galactokinase [Vibrio cholerae RC9], gi\|229343297\|gb\|EEO08272.1\| gal... gi\|9656105, gi\|1... - gi\|9656105\|gb\|AAF94749.1\| galactokinase [Vibrio cholerae O1 biovar El Tor str. N16961], gi\|15641603\|... gi\|11354936 - gi\|11354936\|pir\|\|F82181 galactokinase VC1595 [imported] - Vibrio cholerae (strain N16961 serogroup O... gi\|146315450, gi... - gi\|227118055\|ref\|YP_002819951.1\| galactokinase [Vibrio cholerae O395], gi\|227013505\|gb\|ACP09715.1\| g... gi\|121588041, gi... - gi\|121588041\|ref\|ZP_01677791.1\| galactokinase [Vibrio cholerae 2740-80], gi\|121547692\|gb\|EAX57786.1\|... gi\|153222715, gi... - gi\|153222715\|ref\|ZP_01953392.1\| galactokinase [Vibrio cholerae MAK 757], gi\|124118681\|gb\|EAY37424.1\|... gi\|121728431, gi... - gi\|121728431\|ref\|ZP_01681458.1\| galactokinase [Vibrio cholerae V52], gi\|121629304\|gb\|EAX61738.1\| gal... gi\|153818144, gi... - gi\|153818144\|ref\|ZP_01970811.1\| galactokinase [Vibrio cholerae NCTC 8457], gi\|126511330\|gb\|EAZ73924.... gi\|254848713, gi... - gi\|254848713\|ref\|ZP_05238063.1\| galactokinase [Vibrio cholerae MO10], gi\|254844418\|gb\|EET22832.1\| ga... gi\|229351433, gi... - gi\|229511468\|ref\|ZP_04400947.1\| galactokinase [Vibrio cholerae B33], gi\|229351433\|gb\|EEO16374.1\| gal... gi\|227081748, gi... - gi\|227081748\|ref\|YP_002810299.1\| galactokinase [Vibrio cholerae M66-2], gi\|227009636\|gb\|ACP05848.1\| ...	250.0	[0..5]	[423..43]

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Predicted Domain #1

Region A:
Residues: [1-426]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVTCSAPGK VLIAGGYIVL DPQYSGLVIG LTAKGYASTT TLDDKCGTVR VKSPQFINAE  60
   61 WLYNIDWTVS PIRVHQIYEN CELEKNPNPF VQLALFYVIN YFFSTGRQPL CWQDLQVTLQ 120
  121 VDNAYYHQPQ LKPDQTSYPK FNFLNCTLGQ VHKTGLGSSA AMITSLIGSL FLSLRRLTDD 180
  181 TGDKSLKIDD STKVIVHNLA QIAHCSAQGK VGSGFDVGAA TWGSCIYRRF DPKLIEQLLV 240
  241 PYDEQIKNIN FSTELRKIVS KKWSDVVPFQ LPATYCLLMG DVAGGSSTPG MVKKVQQWQK 300
  301 ENPEESKNCF DDLYSRVLSI KNCFLSSESL DSELQSQFRS IRRILQRITV EAKVDIEPLK 360
  361 QTNILDNIEQ LPGVIGVGVP GAGGFDAQFC LAINHTEIIE NVIKTWKDDG VVPMDVSPAF 420
  421 DGLAVE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	65.30103
Match:	1wuuA
Description:	crystal structure of human galactokinase complexed with MgAMPPNP and galactose
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
carbohydrate kinase activity	1.15507603461537	bayes_pls_golite062009
catalytic activity	0.878454819018611	bayes_pls_golite062009
diphosphomevalonate decarboxylase activity	0.58217666811758	bayes_pls_golite062009
nucleic acid binding	0.369771518688522	bayes_pls_golite062009
structural constituent of ribosome	0.325699575011026	bayes_pls_golite062009
transcription regulator activity	0.212099606954236	bayes_pls_golite062009
structural molecule activity	2.19428886088058E-4	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: