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Protein Overview: scp1

General Information:
Name(s) found: scp1 / SPBC3B9.15c [Sanger Pombe]
Description(s) found:
Found 19 descriptions.
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  • sterol regulatory element binding protein Scp1 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 1086 amino acids

    Gene Ontology:
    Cellular Component: SREBP-SCAP complex [IDALink to PubMed article]
    integral to Golgi membrane [TASLink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed article]
    Biological Process: oxygen and reactive oxygen species metabolic process [IMPLink to PubMed article]
    response to hypoxia [TASLink to PubMed article]
    positive regulation of ergosterol biosynthetic process [IMPLink to PubMed article]
    sterol regulatory element binding protein cleavage [IMPLink to PubMed article]
    positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway [IMPLink to PubMed article]
    positive regulation of lipid biosynthetic process [TASLink to PubMed article]
    protein retention in ER lumen [IMPLink to PubMed article]
    Molecular Function: sterol sensor activity [TASLink to PubMed article]
    sterol response element binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRIFTLGKGR ISRGYARQVN PSLFAKYSYC IANNPWYFIL VFTLLSITGI YSSLVAYQQS  60
   61 LYDQSLARWS AWYAESINAE ANVITKQLYL LGTNTSVFSE DYLSNAYRWE TSFHQYLAEY 120
  121 GYPCIRDEKS CVTISPIPKY YGKVDPVAQY SYTKGLPENE REVNKLRNDT IAEGFDSLSA 180
  181 FVITYFLKPE QVDTFHVVLK KFISETPNLY ASLLDTSPTT VVARIPDLTV IYRWYLWVGF 240
  241 GVGLFAYLYL SLVRLHDIRA KFGLTATIFI QSGTAYFSTC SLLYFFERTG PICPWPMAYY 300
  301 IIIFMDIENS FRLLRAVIAS PQTKRVPSRI MEGFSSTIIA SFSSLLKKLL TLFVLSFFVY 360
  361 PLVQEFCLFL ACSFVVSFLL HGSFFLAVLS VDIRRLELQD FLDSNSSNRN SKWWVPYLEY 420
  421 VRFMWSPWII DNLGTVSFHM YVIYLQLQSS TDINGSWRLA SPNIRFLITL YHRLGRILRE 480
  481 RKLFPLITTG WFGDPTFLEA LKEKTMAENL VIALYRPVIL DTVNRRDYTN VYNSFHDRRV 540
  541 WRWSTFFSIL FAIDFAVGLL VKALLRGWSD HDELSTDTTL HEEKFRIEPV PVHHQLDILK 600
  601 IAVSENYKTF ASVGLDRCLV VWDLRQWCTK LVLSKEQMPR TLKAIALDPQ GNYVSLFSKD 660
  661 TLFILNVESP CLMLQHSYHC KPNSKLNVFW MPGTHKDDEW KNFELVVVES SGEIQVFSLT 720
  721 IEIEGADIAL VEKFQLSSPI IKSISIVSPT ANRIACLTES GEVTVYSKKG PVWSPKILSQ 780
  781 NKNYLTETKK DIYGIAMADI LFLARDSGVD MIDLKNDELL HSFTLPPIKV NTFSVGVSNS 840
  841 RFVNGQFRVS SISFCFTHAV TEKVLYYYYG NECNESYIIL NKWDQQPNLV DVHDPDNSLA 900
  901 CLTFDELQEN IHEVEDASEC VMSSDGLYIF GMRRKSSSGI CPTADEKNED NGFTLRNRKL 960
  961 RTGHYNWTSY VPLLDSYMQD MEHKKNTHSG GETQVWEVWM YSQSEKKHRC KSLKMYNSLI1020
 1021 IADPGPSLAV SDRCVAIVLG NYVALVGYGS EIFRDFYQIR NSDEMDRILR RKRKNLQRKR1080
 1081 SGTIGC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..485] PSI-BLAST 75.0 No description for 2j8sA was found.
    2 View Details [486..581] deduced N/A No confident structure predictions are available.
    3 View Details [582..907] PSI-BLAST 53.045757 No description for 2ovpB was found.
    4 View Details [908..1001] PSI-BLAST 38.39794 Crystal Structure of G Protein-Coupled Receptor Kinase 2 in Complex with Galpha-q and Gbetagamma Subunits
    5 View Details [1002..1086] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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