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The process by which a sterol regulatory element binding protein (SREBP) mediates an increase in rate or extent of transcription of nuclear target genes in response to sterol depletion. SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes. A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of altered levels of one or more lipids, and resulting in the activation of transcription by SREBP. The series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of sterol depletion, and resulting in the activation of transcription by SREBP. The process by which a sterol regulatory element binding protein (SREBP) mediates an increase in rate or extent of transcription of nuclear target genes in response to altered levels of one or more lipids. SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs in the promoters of target genes. Any process that increases the frequency, rate or extent of the specifically regulated synthesis of RNA from DNA encoding a specific gene or set of genes by RNA polymerase II (Pol II), originating at a Pol II-specific promoter.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway
Acc: GO:0006994
Aspect: Biological Process
Desc: The process by which a sterol regulatory element binding protein (SREBP) mediates an increase in rate or extent of transcription of nuclear target genes in response to sterol depletion. SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes.
Synonyms:
  • positive regulation of sterol regulatory element binding protein target gene transcription involved in sterol depletion response
  • sterol depletion response, SREBP target gene transcriptional activation
Proteins in PDR annotated with:
   This term: 5 [Search]
   Term or descendants: 5 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0006994 - positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway (interactive image map)
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