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Protein Overview: SPAC227.09

General Information:
Name(s) found: SPAC227.09 [Sanger Pombe]
Description(s) found:
Found 18 descriptions.
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  • folylpolyglutamate synthase [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 417 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [ISSLink to PubMed article]
    mitochondrion [IDALink to PubMed article][ISSLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: glutamate metabolic process [RCALink to PubMed article]
    folic acid and derivative biosynthetic process [ISSLink to PubMed article]
    cellular amino acid metabolic process [RCALink to PubMed article]
    one-carbon metabolic process [IEA]
    Molecular Function: tetrahydrofolylpolyglutamate synthase activity [ISSLink to PubMed article]
    ATP binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPIQLGLQRM LQLLKHLGNP QESFCAVQIA GTNGKGSICS YIYTSLLQAA IKTGRYTSPH  60
   61 FLEPRDTISI NGQIASEEIF NTCWKQVIEV DRRFRTKATE FELLTATAFQ CFHHSGVRVA 120
  121 VIETGMGGRL DATNVFEEPV LSIISRICLD HQAFLGNTLE AIAKEKAGIF KKNVPCVVDG 180
  181 LNEVNVLNQL KLSAEETRAH PFYLAKGKSG ENKNEWIINT PNWGTNTFST PLKGDYQGQN 240
  241 LACAVTALDI LSSSFSIMLP HVQNGVKNTS WPGRLDIRSV PSLGDILFDG AHNKEAAIEL 300
  301 AKFVNSQRRE HNKSVSWVVA FTNTKDVTGI MKILLRKGDT VIATNFSSVS GMPWIKSMEP 360
  361 EVIKNSISSE SSVECYTADN LTISEILRLA KEKNSSVIVC GSLYLLGDMY RYLKLDV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..417] PSI-BLAST 71.69897 Crystal structure of Folylpolyglutamate synthase (TM0166) from Thermotoga maritima at 2.10 A resolution

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • acid-amino acid ligase activity
    		•  4.37731070676891 bayes_pls_golite062009
  • tetrahydrofolylpolyglutamate synthase activity
    		•  3.94486215528378 bayes_pls_golite062009
  • ligase activity
    		•  3.80574681739772 bayes_pls_golite062009
  • catalytic activity
    		•  2.66037860982128 bayes_pls_golite062009
  • dihydrofolate synthase activity
    		•  2.50201834836027 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  1.96801058335544 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle