YRC Public Data Repository - Protein Structure Prediction

Protein:	SPAC227.09
Organism:	Schizosaccharomyces pombe
Length:	417 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPAC227.09.

Description	E-value	Query Range	Subject Range
gi\|53688657 - gi\|53688657\|ref\|ZP_00111127.2\| COG0285: Folylpolyglutamate synthase [Nostoc punctiforme PCC 73102]	308.0	[0..3]	[411..15]
gi\|242257906, gi... - gi\|242257906\|ref\|ZP_04802752.1\| FolC bifunctional protein [Thermoanaerobacter sp. X513], gi\|24223058... gi\|114804496, gi... - gi\|167040832\|ref\|YP_001663817.1\| FolC bifunctional protein [Thermoanaerobacter sp. X514], gi\|1668550...	301.0	[0..3]	[417..18]
gi\|76795846, gi\|... - gi\|76795846\|ref\|ZP_00778217.1\| Folylpolyglutamate synthetase [Thermoanaerobacter ethanolicus ATCC 33... gi\|241903724, gi... - gi\|241903724\|ref\|ZP_04788443.1\| FolC bifunctional protein [Thermoanaerobacter brockii subsp. finnii ...	300.0	[0..3]	[417..18]
gi\|20807265, gi\|... - gi\|20807265\|ref\|NP_622436.1\| folylpolyglutamate synthase [Thermoanaerobacter tengcongensis MB4], gi\|... gi\|20807265 - gi\|20807265\|ref\|NP_622436.1\| Folylpolyglutamate synthase [Thermoanaerobacter tengcongensis MB4]	299.0	[0..3]	[414..21]
gi\|78044302, gi\|... - gi\|78044302\|ref\|YP_359198.1\| folylpolyglutamate synthase [Carboxydothermus hydrogenoformans Z-2901],...	297.0	[0..3]	[416..18]
gi\|77975508 - gi\|77975508\|ref\|ZP_00831043.1\| COG0285: Folylpolyglutamate synthase [Yersinia frederiksenii ATCC 336...	289.0	[0..2]	[413..27]
gi\|28204341, gi\|... - gi\|28211898\|ref\|NP_782842.1\| dihydrofolate synthase [Clostridium tetani E88], gi\|28204341\|gb\|AAO3677...	288.0	[0..6]	[414..21]
gi\|68207251, gi\|... - gi\|68207251\|ref\|ZP_00559419.1\| Folylpolyglutamate synthetase [Desulfitobacterium hafniense DCB-2], g...	288.0	[0..3]	[413..38]
gi\|89895933, gi\|... - gi\|89895933\|ref\|YP_519420.1\| hypothetical protein DSY3187 [Desulfitobacterium hafniense Y51], gi\|893...	288.0	[0..3]	[413..23]
gi\|18310900, gi\|... - gi\|18310900\|ref\|NP_562834.1\| FolC bifunctional protein [Clostridium perfringens str. 13], gi\|1814558...	288.0	[0..3]	[414..18]

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Predicted Domain #1

Region A:
Residues: [1-417]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPIQLGLQRM LQLLKHLGNP QESFCAVQIA GTNGKGSICS YIYTSLLQAA IKTGRYTSPH  60
   61 FLEPRDTISI NGQIASEEIF NTCWKQVIEV DRRFRTKATE FELLTATAFQ CFHHSGVRVA 120
  121 VIETGMGGRL DATNVFEEPV LSIISRICLD HQAFLGNTLE AIAKEKAGIF KKNVPCVVDG 180
  181 LNEVNVLNQL KLSAEETRAH PFYLAKGKSG ENKNEWIINT PNWGTNTFST PLKGDYQGQN 240
  241 LACAVTALDI LSSSFSIMLP HVQNGVKNTS WPGRLDIRSV PSLGDILFDG AHNKEAAIEL 300
  301 AKFVNSQRRE HNKSVSWVVA FTNTKDVTGI MKILLRKGDT VIATNFSSVS GMPWIKSMEP 360
  361 EVIKNSISSE SSVECYTADN LTISEILRLA KEKNSSVIVC GSLYLLGDMY RYLKLDV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	71.69897
Match:	1o5zA
Description:	Crystal structure of Folylpolyglutamate synthase (TM0166) from Thermotoga maritima at 2.10 A resolution
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
acid-amino acid ligase activity	4.37731070676891	bayes_pls_golite062009
tetrahydrofolylpolyglutamate synthase activity	3.94486215528378	bayes_pls_golite062009
ligase activity	3.80574681739772	bayes_pls_golite062009
catalytic activity	2.66037860982128	bayes_pls_golite062009
dihydrofolate synthase activity	2.50201834836027	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	1.96801058335544	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: