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Protein Overview: lub1

General Information:
Name(s) found: lub1 / SPBC887.04c [Sanger Pombe]
Description(s) found:
Found 18 descriptions.
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  • WD repeat protein Lub1 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 713 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    protein complex [RCALink to PubMed article]
    Biological Process: DNA repair [ISSLink to PubMed article]
    proteasomal ubiquitin-dependent protein catabolic process [IMPLink to PubMed article]
    cellular response to stress [IMPLink to PubMed article]
    histone ubiquitination [NASLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]
    ubiquitin binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSYELSREL GGHKQDVRGV CSISNELIGS ASRDGTYSVW EQINGEWTPH FYENHEGFVN  60
   61 CVCYVPAIDK NSRGGQDKCG ILQEVGTNSP SYYLFGHESN ICSASALNSE TIITGSWDST 120
  121 ARVWALGQCK YVLKGHQSSV WAVLALGEDI FITGSADKLI KIWNGEKLVK SILAHNDCVR 180
  181 SLCQIPGGFA SCSNDGVIKL WTSDGEFLYE LHGHTSFVYS LTYIHNQQLI ASCGEDRTIR 240
  241 IWKGKECLQC ITLPTTSVWS VSSLPNGDLV CGSSDGFVRI FTVDKVRVAP TEVLKNFEER 300
  301 VSQFAISSQE VGDIKKGSLP GLEILSKPGK ADGDVVMVRV NNDVEAYQWS QKENEWKKIG 360
  361 QVVDAVGNNR KQLFEGKEYD YVFDVDVADG QAPLKLPYNA TENPYQAANR FLELNQLPLS 420
  421 YTDEVVKFIE KNTQGHSLES KKEPNLESQS SNKIKTTIFP VSQLLFSNAN VPAMCQRLRS 480
  481 LNNTKSNPLP AKSIDSLERA LSSKKITDTE KNELLETCLS ILDSWSLAER FPALDALRLL 540
  541 AINSSSDLAP IFLEVFSRVV KSVPSSGNFE SINVMLALRG LSNVVPNITD AEGVSKLMDC 600
  601 LTSTVPQASS AKDFKIAFAT LAMNLSILLI QLNLENTGIE LLSILFSFLD DPSPDNEAFY 660
  661 RALMALGTLC TVPDIALAAS QIYHAQSIVH GIAERFSQEM RFVDAEKQIL SLF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..84] PSI-BLAST 64.522879 No description for 2ovpB was found.
    2 View Details [85..213] PSI-BLAST 4.154902 Surface layer protein
    3 View Details [214..544] PSI-BLAST 11.69897 Crystal Structure analysis of the beta-propeller protein Ski8p
    4 View Details [545..713] Pfam 6.585027 No description for PF08324.2 was found. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  3.10232773079579 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  2.89805111479917 bayes_pls_golite062009
  • binding
    		•  2.42570478946173 bayes_pls_golite062009
  • protein binding
    		•  2.26925404328312 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  2.01595241503145 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.900963766598159 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.879332537553732 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.734230328744066 bayes_pls_golite062009
  • actin binding
    		•  0.708446291495757 bayes_pls_golite062009
  • histone binding
    		•  0.685319917508843 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.579815310385678 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  0.311523647180993 bayes_pls_golite062009
  • DNA binding
    		•  0.296423033247139 bayes_pls_golite062009
  • protein kinase activity
    		•  0.229242350006544 bayes_pls_golite062009
  • chromatin binding
    		•  0.145491963066342 bayes_pls_golite062009
  • phospholipase A2 activator activity
    		•  0.0696962213283392 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.88

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle