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Protein Overview: hem1

General Information:
Name(s) found: hem1 / SPAC2F3.09 [Sanger Pombe]
Description(s) found:
Found 19 descriptions.
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  • 5-aminolevulinate synthase [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 558 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [ISSLink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    Biological Process: heme biosynthetic process [ISSLink to PubMed article]
    Molecular Function: pyridoxal phosphate binding [IEA]
    transaminase activity [ISSLink to PubMed article]
    5-aminolevulinate synthase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MERVVKLAAK HCPFVSKADP SALRRMAGAG LIRAGARCPV VRHALPVAAA TGADVSRGFK  60
   61 SDSKQMAMEP SLDEIHLKAG VVNTGSRTCR HADAVKAAAE AATTTPVTKK HQMPKHYASD 120
  121 LNGVGPATTP RFDYDTFYRE ELDKKHRDKS YRYFNNINRL AKEYPLAHLA DPNTRVEVWC 180
  181 SNDYLNMGGH KKIREAMHQC IETYGGGAGG TRNIAGHNQH AVRLEKSLAD LHQKPAALVF 240
  241 GSCYVANDAT LSTLGRKLPN CIFLSDEMNH ASMINGIRNS RCEKIIFKHN DLVDLEAKLA 300
  301 SLPLNRPKII AFESVYSMSG NVAPISEICD LAKKYGAITF LDEVHAVGMY GPRGAGVAEE 360
  361 TPGLLSRVDI ITGTLAKSYG CVGGYIAASS TLVDMIRSLA PGFIFTTSLP PHVMVGALTA 420
  421 VEHLKVSNVE REQQRSAVRR VKQSLSEIGI PVLSNDTHIV PAMVGDAHLA KLASDSLLHD 480
  481 HNIYVQSINF PTVSVGTERL RITPTPAHNT EHYVQSLTNA MNDVWSKFNI NRIDGWEKRG 540
  541 IDVGRLCKFP VLPFTTTH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..131] deduced N/A No confident structure predictions are available.
    2 View Details [132..558] PSI-BLAST 65.0 5-Aminolevulinate Synthase from Rhodobacter capsulatus

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • L-aspartate:2-oxoglutarate aminotransferase activity
    		•  3.359406422625 bayes_pls_golite062009
  • 5-aminolevulinate synthase activity
    		•  3.15163480353521 bayes_pls_golite062009
  • catalytic activity
    		•  2.29878871754893 bayes_pls_golite062009
  • N-succinyltransferase activity
    		•  1.81799375593294 bayes_pls_golite062009
  • threonine aldolase activity
    		•  1.80396420390785 bayes_pls_golite062009
  • adenosylmethionine-8-amino-7-oxononanoate transaminase activity
    		•  1.74778109525713 bayes_pls_golite062009
  • glycine dehydrogenase (decarboxylating) activity
    		•  1.63055151623667 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
    		•  1.63055151623667 bayes_pls_golite062009
  • transferase activity, transferring nitrogenous groups
    		•  1.28316822767388 bayes_pls_golite062009
  • transaminase activity
    		•  1.24990480711889 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  1.19150094103499 bayes_pls_golite062009
  • glycine C-acetyltransferase activity
    		•  0.935794708043259 bayes_pls_golite062009
  • transferase activity
    		•  0.737426388870721 bayes_pls_golite062009
  • carbon-sulfur lyase activity
    		•  0.698312655247044 bayes_pls_golite062009
  • vitamin binding
    		•  0.66463470119531 bayes_pls_golite062009
  • intramolecular transferase activity, transferring amino groups
    		•  0.659071155545801 bayes_pls_golite062009
  • binding
    		•  0.462716421837165 bayes_pls_golite062009
  • cystathionine beta-lyase activity
    		•  0.15938456446406 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.0776397323445919 bayes_pls_golite062009
  • sulfurtransferase activity
    		•  0.0450490929307473 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.0150950313851779 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle