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Protein Overview: grx4

General Information:
Name(s) found: grx4 / SPBC26H8.06 [Sanger Pombe]
Description(s) found:
Found 22 descriptions.
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  • glutaredoxin Grx4 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 244 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: removal of superoxide radicals [ICLink to PubMed article]
    cellular response to oxidative stress [NASLink to PubMed article]
    cell redox homeostasis [IEA]
    Molecular Function: protein disulfide oxidoreductase activity [NAS]
    arsenate reductase (glutaredoxin) activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVEITFVEQ FQEILQNGKE QIILLNFYAP WAAPCKQMNQ VFDQFAKDTK NAVFLKIEAE  60
   61 KFSDIAESFD VNAVPLFVLI HGAKVLARIS GANPQKLKAA IDEYIQPLIS QISSTNASVE 120
  121 TQVNSVQTTN TTSNTSKAPN GLDSELNERL STLTNAHNVM LFLKGTPSEP ACGFSRKLVG 180
  181 LLREQNVQYG FFNILADDSV RQGLKVFSDW PTFPQLYIKG EFVGGLDIVS EMIENGELQE 240
  241 MLPN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..141] PSI-BLAST 25.09691 Thioredoxin
    2 View Details [142..244] PSI-BLAST 19.221849 Solution structure of Grx4, a monothiol glutaredoxin from E. coli.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • antioxidant activity
    		•  3.8464796631544 bayes_pls_golite062009
  • peroxidase activity
    		•  3.43831566988273 bayes_pls_golite062009
  • oxidoreductase activity, acting on peroxide as acceptor
    		•  3.43831566988273 bayes_pls_golite062009
  • glutathione peroxidase activity
    		•  2.56524997297011 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  2.23310780102446 bayes_pls_golite062009
  • peroxiredoxin activity
    		•  2.12777217096121 bayes_pls_golite062009
  • selenium binding
    		•  1.97148144306198 bayes_pls_golite062009
  • thioredoxin peroxidase activity
    		•  1.96134566495756 bayes_pls_golite062009
  • protein disulfide oxidoreductase activity
    		•  1.47769936616412 bayes_pls_golite062009
  • disulfide oxidoreductase activity
    		•  1.32811008894503 bayes_pls_golite062009
  • binding
    		•  1.25802922431343 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.96297634785608 bayes_pls_golite062009
  • catalytic activity
    		•  0.672192331361968 bayes_pls_golite062009
  • hydrolase activity
    		•  0.620302638089385 bayes_pls_golite062009
  • glutathione binding
    		•  0.2456976890622 bayes_pls_golite062009
  • protein binding
    		•  0.134341907247724 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle