Protein Overview: trp1

General Information:
Name(s) found:	trp1 / SPBC1539.09c [Sanger Pombe]
Description(s) found: Found 19 descriptions. SHOW ALL	anthranilate synthase component II [Sanger Pombe]
Organism:	Schizosaccharomyces pombe
Length:	759 amino acids
Gene Ontology:
Cellular Component:	cytosol [IDA] anthranilate synthase complex [ISS]
Biological Process:	tryptophan biosynthetic process [ISS] glutamine metabolic process [IEA]
Molecular Function:	indole-3-glycerol-phosphate synthase activity [ISS] phosphoribosylanthranilate isomerase activity [IEA] anthranilate synthase activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEKVDVGES VKGDASENAV KEVAERPIVM IDNYDSFTWN VVQYLSNLEK RYPIMVFRND  60
   61 EITVDELEKL NPLKLVLSPG PGHPARDGGI CNEAISRFAG KIPILGVCMG LQCIFETMGG 120
  121 KVDSAGEIIH GKVSKINHDG LGFYQGIPQN ISVTRYHSLA GKISSLPDCL DVTSWTENGV 180
  181 IMGARHKKYA IEGVQYHPES ILSEYGKEYI QNFLNLTAGT WEENGIVMPT KNNAFNAAMR 240
  241 ENSNSVSSTK IRKQESILEK IHAQRLIDIA ESKRKPGLSV GDLQTYLNLN IAPPCINFYE 300
  301 RLKQSKPALM AEVKRASPSK GDIKLDANAA IQALTYAQVG ASVISVLTEP KWFKGSLNDL 360
  361 FVARKAVEHV ANRPAILRKD FIIDPYQIME ARLNGADSVL LIVAMLSREQ LESLYKFSKS 420
  421 LGMEPLVEVN CAEEMKTAIE LGAKVIGVNN RNLHSFEVDL STTSKLAEMV PDDVILAALS 480
  481 GISSPADVAH YSSQGVSAVL VGESLMRASD PAAFARELLN LSSSEISNGK KTSTPLVKVC 540
  541 GTRSLLAAKT IVESGGDLIG LIFVEKSKRK VDLSVAKEIS HFVHTTNRKH ISPKKAVTGQ 600
  601 SWFDHQYENL ASSPHPLLVG VFQNQPLEYI RSIIAEVNLD IVQLHGQEPF EWIHMLDRPV 660
  661 IKVFPLNSSE ISRPNYHIVP LIDAYVGGES GGLGKKVDWE AASFIPVSYV LAGGLTPKNV 720
  721 QDAISVSRPA VVDVSSGVET DGKQDLEKIK AFINAVKEL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..224]	PSI-BLAST	39.69897	Anthranilate synthase GAT subunit, TrpG
2	View Details	[225..322]	PSI-BLAST	3.30103	No description for 2dplA was found.
3	View Details	[323..527]	PSI-BLAST	25.154902	REFINED STRUCTURE OF SPINACH GLYCOLATE OXIDASE AT 2 ANGSTROMS RESOLUTION
4	View Details	[528..759]	PSI-BLAST	101.0	THREE-DIMENSIONAL STRUCTURE OF THE BIFUNCTIONAL ENZYME PHOSPHORIBOSYLANTHRANILATE ISOMERASE: INDOLEGLYCEROLPHOSPHATE SYNTHASE FROM ESCHERICHIA COLI REFINED AT 2.0 ANGSTROMS RESOLUTION

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
anthranilate synthase activity	9.07528926783927	bayes_pls_golite062009
oxo-acid-lyase activity	7.16633518631507	bayes_pls_golite062009
4-amino-4-deoxychorismate synthase activity	4.48164623771604	bayes_pls_golite062009
indole-3-glycerol-phosphate synthase activity	4.14261580175621	bayes_pls_golite062009
ligase activity	1.70348758031146	bayes_pls_golite062009
catalytic activity	1.30391542469987	bayes_pls_golite062009
nucleic acid binding	0.86323855032533	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	0.628648036096965	bayes_pls_golite062009
binding	0.588714599255874	bayes_pls_golite062009
imidazoleglycerol-phosphate synthase activity	0.270391651600004	bayes_pls_golite062009
carbon-carbon lyase activity	0.0769356405014503	bayes_pls_golite062009
protein binding	0.0152024556625711	bayes_pls_golite062009

2

No functions predicted.

3

Term	Confidence	Notes
oxidoreductase activity	2.15666801512485	bayes_pls_golite062009
catalytic activity	1.94749091175302	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	1.03631792578914	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	0.962937319088834	bayes_pls_golite062009
nucleic acid binding	0.863669046462436	bayes_pls_golite062009
binding	0.638680034811594	bayes_pls_golite062009
glutamate synthase activity	0.272973710155811	bayes_pls_golite062009

4

Term	Confidence	Notes
indole-3-glycerol-phosphate synthase activity	8.59736519932798	bayes_pls_golite062009
anthranilate synthase activity	5.47492192345361	bayes_pls_golite062009
oxo-acid-lyase activity	4.09809510052304	bayes_pls_golite062009
tryptophan synthase activity	2.99898167480072	bayes_pls_golite062009
phosphoribosylanthranilate isomerase activity	2.57188946638955	bayes_pls_golite062009
catalytic activity	2.44231061702877	bayes_pls_golite062009
carbon-carbon lyase activity	1.80077901589281	bayes_pls_golite062009
carboxy-lyase activity	1.32677036501434	bayes_pls_golite062009
ribulose-phosphate 3-epimerase activity	0.966175242934785	bayes_pls_golite062009
binding	0.626392473915547	bayes_pls_golite062009
imidazoleglycerol-phosphate synthase activity	0.567370625225674	bayes_pls_golite062009
lyase activity	0.258652421339738	bayes_pls_golite062009
protein binding	0.014429239696785	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

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