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Protein Overview: swi6

General Information:
Name(s) found: swi6 / SPAC664.01c [Sanger Pombe]
Description(s) found:
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  • pir||T39111 chromatin-associated swi6 protein [imported] - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|730857|sp|P40381.1|SWI6_SCHPO RecName: Full=Chromatin-associated protein swi6 [NCBI NR]
  • gi|6692008|emb|CAB65802.1| SPAC664.01c [Schizosaccharomyces pombe] [NCBI NR]
  • gi|6013107|emb|CAB57340.1| chromodomain protein Swi6 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|510930|emb|CAA50668.1| swi6 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19114361|ref|NP_593449.1| chromodomain protein Swi6 [Schizosaccharomyces pombe] [NCBI NR]
  • chromodomain protein Swi6 [Sanger Pombe]
  • Chromatin-associated protein swi6 OS=Schizosaccharomyces pombe GN=swi6 PE=1 SV=1 [Swiss-Prot]
  • DETERMINES MATING-TYPE DONOR CHOICE; REQUIRED FOR TRANSCRIPTIONAL SILENCING AT THE MATING TYPE LOCI; REQUIRED FOR CHROMOSOME SEGREGATION; CHROMODOMAIN PROTEIN; BINDS CENTROMERIC FLANKING SEQUENCE; NO APPARENT S. CEREVISIAE ORTHOLOG: P40381; [pompepVF.fasta]
  • PROTEIN THAT DETERMINES MATING-TYPE DONOR CHOICE; REQUIRED FOR TRANSCRIPTIONAL SILENCING AT THE MATING TYPE LOCI; REQUIRED FOR CHROMOSOME SEGREGATION: P40381; [pompepV13]
  • Chromatin-associated swi6 protein [pompep4896]
  • |swi6|SPAC824.10c|determines mating-type donor choice [pompepnew.fasta]
  • |swi6|SPAC824.10c|heterochromatin protein 1 (HP1)|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • |swi6|SPAC824.10c|heterochromatin protein 1 |Schizosaccharomyces pombe|chr 1|||Manual [pompep2242005.fasta]
  • swi6 protein; repression of silent mating type loci [Schizosaccharomyces pombe]gi|510930|emb|CAA50668.1| swi6 [Schizosaccharomyces pombe]gi|6692008|emb|CAB65802.1| swi6 [Schizosaccharomyces pombe]gi|6013107|emb|CAB57340.1| swi6 [Schizosaccharomyces pom [nrdb_11152004_Chlamydomonas]
  • (P40381) Chromatin-associated swi6 protein [pompep4896_normal_reversed]
  • |swi6|SPAC824.10c|chromodomain protein Swi6|Schizosaccharomyces pombe|chr 1|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • swi6 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • SPAC664.01c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • Chromatin-associated protein swi6 [nr-271106-contam.fasta]
  • hypothetical protein SPAC664.01c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • Chromatin-associated protein swi6 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=swi6 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 328 amino acids

    Gene Ontology:
    Cellular Component: mating-type region heterochromatin [IDALink to PubMed article]
    nucleus [IDALink to PubMed article]
    nuclear telomeric heterochromatin [IDALink to PubMed article]
    spindle pole body [IDALink to PubMed article]
    centromeric heterochromatin [TASLink to PubMed article]
    Biological Process: sister chromatid cohesion [IGILink to PubMed article]
    chromatin remodeling [RCALink to PubMed article]
    chromatin silencing at centromere [IMPLink to PubMed article]
    chromatin assembly or disassembly [IEA]
    chromatin silencing at silent mating-type cassette [IMPLink to PubMed article]
    donor selection [IMPLink to PubMed article]
    chromatin silencing at telomere [IMPLink to PubMed article]
    mating type switching [IMPLink to PubMed article]
    cellular protein localization [IGILink to PubMed articleLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    chromatin binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKGGVRSYR RSSTSKRSVI DDDSEPELPS MTKEAIASHK ADSGSSDNEV ESDHESKSSS  60
   61 KKLKENAKEE EGGEEEEEDE YVVEKVLKHR MARKGGGYEY LLKWEGYDDP SDNTWSSEAD 120
  121 CSGCKQLIEA YWNEHGGRPE PSKRKRTARP KKPEAKEPSP KSRKTDEDKH DKDSNEKIED 180
  181 VNEKTIKFAD KSQEEFNENG PPSGQPNGHI ESDNESKSPS QKESNESEDI QIAETPSNVT 240
  241 PKKKPSPEVP KLPDNRELTV KQVENYDSWE DLVSSIDTIE RKDDGTLEIY LTWKNGAISH 300
  301 HPSTITNKKC PQKMLQFYES HLTFRENE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..76] deduced N/A No confident structure predictions are available.
    2 View Details [77..172] PSI-BLAST 9.30103 Tandem chromodomains of human CHD1 complexed with Histone H3 Tail containing trimethyllysine 4 and dimethylarginine 2
    3 View Details [173..255] deduced N/A No confident structure predictions are available.
    4 View Details [256..328] PSI-BLAST 21.154902 Heterochromatin protein 1, HP1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription repressor activity
    		•  4.08500855631983 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.64390820819794 bayes_pls_golite062009
  • chromatin binding
    		•  3.1924157640698 bayes_pls_golite062009
  • binding
    		•  3.06758476214113 bayes_pls_golite062009
  • methylated histone residue binding
    		•  2.71235155233989 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.19167058827256 bayes_pls_golite062009
  • DNA binding
    		•  2.05514577638135 bayes_pls_golite062009
  • protein binding
    		•  1.61683263008775 bayes_pls_golite062009
  • histone binding
    		•  1.48525673080866 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.998957812785999 bayes_pls_golite062009
  • general transcriptional repressor activity
    		•  0.75184432495983 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.726970683178132 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.494788451379878 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.294457188332415 bayes_pls_golite062009
  • catalytic activity
    		•  0.14067200158938 bayes_pls_golite062009
  • transcription activator activity
    		•  0.136090220479238 bayes_pls_golite062009
    3 No functions predicted.
    4
    Term Confidence Notes
  • transcription repressor activity
    		•  4.08500855631983 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.64390820819794 bayes_pls_golite062009
  • chromatin binding
    		•  3.1924157640698 bayes_pls_golite062009
  • binding
    		•  3.06758476214113 bayes_pls_golite062009
  • methylated histone residue binding
    		•  2.71235155233989 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.19167058827256 bayes_pls_golite062009
  • DNA binding
    		•  2.05514577638135 bayes_pls_golite062009
  • protein binding
    		•  1.61683263008775 bayes_pls_golite062009
  • histone binding
    		•  1.48525673080866 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.998957812785999 bayes_pls_golite062009
  • general transcriptional repressor activity
    		•  0.75184432495983 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.726970683178132 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.494788451379878 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.294457188332415 bayes_pls_golite062009
  • catalytic activity
    		•  0.14067200158938 bayes_pls_golite062009
  • transcription activator activity
    		•  0.136090220479238 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle